Detailed information NTG0997042

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: ABC803_RS05035
• Genome accession: NZ_CP155531
• Coordinates: 938117..938767 (+)
• Length: 216 a.a.
• NCBI ID: WP_000387328.1
• Uniprot ID: A0A4N9N7Z7
• Organism: Streptococcus pneumoniae strain SN36255
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 933117..943767

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
ABC803_RS05005 (ABC803_05005)	-	933600..933815 (+)	216	WP_001232081.1	YozE family protein	-
ABC803_RS05010 (ABC803_05010)	-	933901..934869 (+)	969	WP_000658198.1	PhoH family protein	-
ABC803_RS05015 (ABC803_05015)	-	935062..935562 (+)	501	WP_000566986.1	GNAT family N-acetyltransferase	-
ABC803_RS05020 (ABC803_05020)	-	935565..935891 (+)	327	Protein_941	TfoX/Sxy family protein	-
ABC803_RS05025 (ABC803_05025)	ald	936192..937303 (-)	1112	Protein_942	alanine dehydrogenase	-
ABC803_RS05030 (ABC803_05030)	-	937480..938049 (+)	570	WP_000443775.1	GNAT family N-acetyltransferase	-
ABC803_RS05035 (ABC803_05035)	comEA/celA/cilE	938117..938767 (+)	651	WP_000387328.1	ComEA family DNA-binding protein	Machinery gene
ABC803_RS05040 (ABC803_05040)	comEC/celB	938751..940991 (+)	2241	WP_000942392.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
ABC803_RS05045 (ABC803_05045)	-	941133..941357 (+)	225	WP_000583432.1	hypothetical protein	-
ABC803_RS05050 (ABC803_05050)	-	941390..941977 (+)	588	WP_000939884.1	ABC transporter ATP-binding protein	-
ABC803_RS05055 (ABC803_05055)	-	941981..943162 (+)	1182	WP_000655951.1	membrane protein	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23230.59 Da
• Isoelectric Point: 5.0667

>NTDB_id=997042 ABC803_RS05035 WP_000387328.1 938117..938767(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain SN36255]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEEEVNKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGLGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=997042 ABC803_RS05035 WP_000387328.1 938117..938767(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain SN36255]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT
TTTCCTGCTAAAACCAGCTCCACAAACACCTGTCAAAGAGACGAATTTGCAGGCTGAAGTCGCAGCTGTTTCCAAGGATT
TGGTATCCGAAGAGGAAGTGAACAAGGAAGAAAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGCCAACAGACTGGTTTGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (76-126)

• Helix-hairpin-helix motif (HHH_3) (151-214)

3D structure

• AlphaFold DB: A0A4N9N7Z7

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae D39	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae R6	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	96.759	100	0.968
comEA/celA/cilE	Streptococcus mitis NCTC 12261	95.833	100	0.958
comEA/celA/cilE	Streptococcus mitis SK321	89.815	100	0.898
comEA	Lactococcus lactis subsp. cremoris KW2	43.172	100	0.454
comEA	Bacillus subtilis subsp. subtilis str. 168	41.579	87.963	0.366