Detailed information NTG0989176

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: AAFQ93_RS06050
• Genome accession: NZ_CP152419
• Coordinates: 1273888..1274592 (+)
• Length: 234 a.a.
• NCBI ID: WP_000722070.1
• Uniprot ID: I2IYV6
• Organism: Streptococcus nidrosiense strain SO-23-1
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1268888..1279592

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAFQ93_RS06030 (AAFQ93_06015)	-	1269522..1269686 (+)	165	WP_000502583.1	hypothetical protein	-
AAFQ93_RS06035 (AAFQ93_06020)	-	1269722..1270192 (-)	471	WP_001030117.1	arginine repressor	-
AAFQ93_RS06040 (AAFQ93_06025)	-	1270143..1272482 (-)	2340	WP_375554924.1	Xaa-Pro dipeptidyl-peptidase	-
AAFQ93_RS06045 (AAFQ93_06030)	mutY	1272660..1273823 (+)	1164	WP_375554925.1	A/G-specific adenine glycosylase	-
AAFQ93_RS06050 (AAFQ93_06035)	micA	1273888..1274592 (+)	705	WP_000722070.1	response regulator YycF	Regulator
AAFQ93_RS06055 (AAFQ93_06040)	micB	1274585..1275934 (+)	1350	WP_223140896.1	cell wall metabolism sensor histidine kinase VicK	Regulator
AAFQ93_RS06060 (AAFQ93_06045)	vicX	1275936..1276745 (+)	810	WP_045763287.1	MBL fold metallo-hydrolase	Regulator
AAFQ93_RS06065 (AAFQ93_06050)	relB	1276835..1277077 (+)	243	WP_223140897.1	type II toxin-antitoxin system RelB family antitoxin	-
AAFQ93_RS06070 (AAFQ93_06055)	-	1277079..1277333 (+)	255	WP_045763285.1	type II toxin-antitoxin system RelE/ParE family toxin	-
AAFQ93_RS06075 (AAFQ93_06060)	-	1277386..1278159 (+)	774	WP_223140898.1	potassium channel family protein	-
AAFQ93_RS06080 (AAFQ93_06065)	-	1278296..1278643 (-)	348	WP_049508487.1	thiol reductase thioredoxin	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26965.79 Da
• Isoelectric Point: 4.6697

>NTDB_id=989176 AAFQ93_RS06050 WP_000722070.1 1273888..1274592(+) (micA) [Streptococcus nidrosiense strain SO-23-1]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPIIMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRTDIVSVDNQEPETKLQSLQIGDLEILPDAYVAKKYGEELDLT
HREFELLHHLASHLGQVITREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMRNND

Nucleotide

• Length: 705 bp

>NTDB_id=989176 AAFQ93_RS06050 WP_000722070.1 1273888..1274592(+) (micA) [Streptococcus nidrosiense strain SO-23-1]
ATGAAAAAAATACTAATTGTAGATGATGAAAAACCCATCTCAGATATTATAAAATTTAATATGACCAAGGAAGGTTATGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCTCTTGAACAATTTGAAGCTGAGCAACCAGATATTATTATCTTGGATTTGA
TGCTTCCAGAGATTGATGGACTTGAAGTTGCAAAAACTATTCGTAAGACAAGTAGTGTTCCTATTATCATGCTTTCAGCA
AAGGACAGCGAGTTTGATAAGGTTATTGGGCTTGAACTTGGAGCGGATGACTATGTAACCAAGCCATTTTCAAATCGTGA
ACTACAGGCCCGTGTTAAAGCTCTTCTCCGTCGTACAGATATTGTCTCAGTTGATAACCAAGAACCTGAAACGAAATTAC
AAAGTCTGCAGATTGGCGATTTGGAGATTTTACCCGATGCTTACGTGGCTAAGAAATATGGTGAAGAGTTAGACCTAACC
CACCGAGAATTCGAACTCTTACATCATTTAGCTTCTCATCTTGGTCAAGTTATTACCCGAGAACATCTTCTTGAAACTGT
TTGGGGATATGACTATTTTGGAGATGTCCGTACAGTTGATGTAACAATTAGACGTTTGCGCGAGAAGATTGAAGACACAC
CAAGTAGACCTGAATACATCCTAACTCGTCGTGGAGTAGGATATTATATGAGAAATAATGATTGA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: I2IYV6

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	92.704	99.573	0.923
vicR	Streptococcus mutans UA159	79.149	100	0.795
covR	Streptococcus salivarius strain HSISS4	44.783	98.291	0.44
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.913	98.291	0.432
scnR	Streptococcus mutans UA159	37.5	99.145	0.372