Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   R8570_RS04290 Genome accession   NZ_AP026932
Coordinates   854911..855561 (+) Length   216 a.a.
NCBI ID   WP_000387332.1    Uniprot ID   A0A6I3U9C7
Organism   Streptococcus pneumoniae strain PZ900701549     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 849911..860561
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8570_RS04260 (PC1528_08470) - 850394..850609 (+) 216 WP_001232082.1 YozE family protein -
  R8570_RS04265 (PC1528_08480) - 850695..851663 (+) 969 WP_000658183.1 PhoH family protein -
  R8570_RS04270 (PC1528_08490) - 851856..852356 (+) 501 WP_000566988.1 GNAT family N-acetyltransferase -
  R8570_RS04275 (PC1528_08500) - 852359..852685 (+) 327 Protein_844 TfoX/Sxy family protein -
  R8570_RS04280 ald 852986..854097 (-) 1112 Protein_845 alanine dehydrogenase -
  R8570_RS04285 (PC1528_08540) - 854274..854843 (+) 570 WP_000443775.1 GNAT family N-acetyltransferase -
  R8570_RS04290 (PC1528_08550) comEA/celA/cilE 854911..855561 (+) 651 WP_000387332.1 helix-hairpin-helix domain-containing protein Machinery gene
  R8570_RS04295 (PC1528_08560) comEC/celB 855545..857785 (+) 2241 WP_000942425.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  R8570_RS04300 (PC1528_08570) - 857964..858152 (+) 189 WP_044812623.1 hypothetical protein -
  R8570_RS04305 (PC1528_08580) - 858185..858772 (+) 588 WP_000939884.1 ATP-binding cassette domain-containing protein -
  R8570_RS04310 (PC1528_08590) - 858776..859957 (+) 1182 WP_054395574.1 hypothetical protein -

Sequence

Protein


Download         Length: 216 a.a.        Molecular weight: 23219.57 Da        Isoelectric Point: 5.5171

>NTDB_id=98889 R8570_RS04290 WP_000387332.1 854911..855561(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain PZ900701549]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSTSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSIDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide


Download         Length: 651 bp        

>NTDB_id=98889 R8570_RS04290 WP_000387332.1 854911..855561(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain PZ900701549]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTAAAGGAAACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAACAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAGCTTAAACAGGTTAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATAGACCATCGTGAGGCAAATGG
GAAATTCAAGTCGATTGATGAACTCAAGAAGGTCTCTGGCATTGGTGCTAAGACCATAGAAAAGCTAAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

Helix-hairpin-helix motif (HHH_3)

(151-214)

SLBB domain (SLBB)

(76-126)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A6I3U9C7

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae Rx1

98.148

100

0.981
  comEA/celA/cilE Streptococcus pneumoniae D39

98.148

100

0.981
  comEA/celA/cilE Streptococcus pneumoniae R6

98.148

100

0.981
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

97.222

100

0.972
  comEA/celA/cilE Streptococcus mitis NCTC 12261

96.759

100

0.968
  comEA/celA/cilE Streptococcus mitis SK321

91.204

100

0.912
  comEA Lactococcus lactis subsp. cremoris KW2

44.053

100

0.463
  comEA Latilactobacillus sakei subsp. sakei 23K

34.335

100

0.37
  comEA Bacillus subtilis subsp. subtilis str. 168

42.105

87.963

0.37

Multiple sequence alignment