Detailed information NTG0098881

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: R8570_RS02350
• Genome accession: NZ_AP026932
• Coordinates: 475062..475649 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain PZ900701549
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 470062..480649

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8570_RS02330 (PC1528_04640)	-	470523..471863 (+)	1341	WP_001099895.1	sensor histidine kinase	-
R8570_RS02335 (PC1528_04650)	blpC	471908..472063 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
R8570_RS02340 (PC1528_04660)	-	472120..473481 (-)	1362	WP_001069060.1	bacteriocin secretion accessory protein	-
R8570_RS02345 (PC1528_04670)	comA/nlmT	473492..475168 (-)	1677	WP_196300924.1	peptide cleavage/export ABC transporter	Regulator
R8570_RS02350 (PC1528_04680)	comA/nlmT	475062..475649 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
R8570_RS02355 (PC1528_04690)	blpU	475930..476160 (+)	231	WP_001093268.1	bacteriocin-like peptide BlpU	-
R8570_RS02360	-	476163..476282 (+)	120	WP_000346298.1	PncF family bacteriocin immunity protein	-
R8570_RS02365 (PC1528_04700)	-	476579..476743 (+)	165	WP_000727118.1	hypothetical protein	-
R8570_RS02370 (PC1528_04710)	-	476740..477144 (+)	405	WP_000846944.1	hypothetical protein	-
R8570_RS02375	-	477342..478147 (+)	806	Protein_466	IS5 family transposase	-
R8570_RS02380 (PC1528_04740)	blpM	478349..478603 (+)	255	WP_000379879.1	two-peptide bacteriocin subunit BlpM	-
R8570_RS02385 (PC1528_04750)	blpN	478619..478822 (+)	204	WP_001099492.1	two-peptide bacteriocin subunit BlpN	-
R8570_RS02390 (PC1528_04760)	cipB	479066..479215 (+)	150	WP_001813641.1	bacteriocin-like peptide BlpO	Regulator
R8570_RS02395	-	479319..479438 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
R8570_RS02400 (PC1528_04780)	-	480224..480607 (+)	384	WP_000877378.1	hypothetical protein	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=98881 R8570_RS02350 WP_000205166.1 475062..475649(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900701549]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=98881 R8570_RS02350 WP_000205166.1 475062..475649(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900701549]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497