Detailed information NTG0098726

Bioinformatically predicted

Overview

• Name: comE/blpR
• Type: Regulator
• Locus tag: R8624_RS02365
• Genome accession: NZ_AP026930
• Coordinates: 459498..460235 (+)
• Length: 245 a.a.
• NCBI ID: WP_001219126.1
• Uniprot ID: A7XHJ0
• Organism: Streptococcus pneumoniae strain PZ900701208
• Function: activate transcription of early competence genes; regulation of comX expression (predicted from homology) Competence regulation

Genomic Context

Location: 454498..465235

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8624_RS02330	-	455474..455668 (-)	195	WP_001808905.1	hypothetical protein	-
R8624_RS02335 (PC1195_04470)	-	455830..456117 (-)	288	WP_000777760.1	hypothetical protein	-
R8624_RS02340 (PC1195_04480)	-	456127..456537 (-)	411	WP_001112361.1	HIT family protein	-
R8624_RS02345 (PC1195_04490)	pptA	456605..457336 (+)	732	WP_000889923.1	ABC transporter ATP-binding protein	Regulator
R8624_RS02350 (PC1195_04500)	-	457333..458382 (+)	1050	WP_050311723.1	ABC transporter permease	-
R8624_RS02355 (PC1195_04510)	-	458550..458879 (-)	330	WP_000132575.1	hypothetical protein	-
R8624_RS02360 (PC1195_04520)	-	459155..459493 (+)	339	WP_000682121.1	LytTR family DNA-binding domain-containing protein	-
R8624_RS02365 (PC1195_04530)	comE/blpR	459498..460235 (+)	738	WP_001219126.1	response regulator transcription factor	Regulator
R8624_RS02370 (PC1195_04540)	-	460248..461588 (+)	1341	WP_000275285.1	sensor histidine kinase	-
R8624_RS02375 (PC1195_04550)	blpC	461633..461788 (-)	156	WP_000358814.1	quorum-sensing system pheromone BlpC	-
R8624_RS02380 (PC1195_04560)	-	461845..463206 (-)	1362	WP_050311724.1	bacteriocin secretion accessory protein	-
R8624_RS02385 (PC1195_04570)	comA	463217..463486 (-)	270	WP_317650355.1	hypothetical protein	Regulator
R8624_RS02390 (PC1195_04580)	comA/nlmT	463462..463929 (-)	468	WP_317650241.1	ATP-binding cassette domain-containing protein	Regulator
R8624_RS02395 (PC1195_04590)	comA/nlmT	464134..464841 (-)	708	WP_317650242.1	ABC transporter transmembrane domain-containing protein	Regulator

Sequence

Protein

• Length: 245 a.a.
• Molecular weight: 28752.92 Da
• Isoelectric Point: 6.2357

>NTDB_id=98726 R8624_RS02365 WP_001219126.1 459498..460235(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900701208]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide

• Length: 738 bp

>NTDB_id=98726 R8624_RS02365 WP_001219126.1 459498..460235(+) (comE/blpR) [Streptococcus pneumoniae strain PZ900701208]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTGGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (3-122)

• LytTr DNA-binding domain (LytTR) (151-241)

3D structure

• AlphaFold DB: A7XHJ0

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comE/blpR	Streptococcus mutans UA159	53.909	99.184	0.535
comE/comE1	Streptococcus equinus JB1	43.882	96.735	0.424
comE/comE2	Streptococcus equinus JB1	38.843	98.776	0.384