Detailed information NTG0986319

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: NST80_RS04300
• Genome accession: NZ_CP152039
• Coordinates: 974631..975305 (+)
• Length: 224 a.a.
• NCBI ID: WP_002891134.1
• Uniprot ID: J7TS49
• Organism: Streptococcus sp. FSL K6-1323
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 969631..980305

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NST80_RS04275 (NST80_04275)	-	970119..970679 (-)	561	WP_004182060.1	ECF transporter S component	-
NST80_RS04280 (NST80_04280)	-	970746..971318 (-)	573	WP_084871334.1	ECF transporter S component	-
NST80_RS04285 (NST80_04285)	coaC	971347..971892 (-)	546	WP_084871335.1	phosphopantothenoylcysteine decarboxylase	-
NST80_RS04290 (NST80_04290)	-	971885..972568 (-)	684	WP_084871336.1	phosphopantothenate--cysteine ligase	-
NST80_RS04295 (NST80_04295)	-	972762..974432 (+)	1671	WP_118171862.1	formate--tetrahydrofolate ligase	-
NST80_RS04300 (NST80_04300)	ciaR	974631..975305 (+)	675	WP_002891134.1	response regulator transcription factor	Regulator
NST80_RS04305 (NST80_04305)	ciaH	975295..976710 (+)	1416	WP_118171861.1	HAMP domain-containing sensor histidine kinase	Regulator
NST80_RS04310 (NST80_04310)	rpsT	976788..977024 (-)	237	WP_004182129.1	30S ribosomal protein S20	-
NST80_RS04315 (NST80_04315)	coaA	977094..978014 (-)	921	WP_022496694.1	type I pantothenate kinase	-
NST80_RS04320 (NST80_04320)	-	978127..978717 (+)	591	WP_014633038.1	class I SAM-dependent methyltransferase	-
NST80_RS04325 (NST80_04325)	-	978714..979991 (+)	1278	WP_342504647.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.02 Da
• Isoelectric Point: 4.2897

>NTDB_id=986319 NST80_RS04300 WP_002891134.1 974631..975305(+) (ciaR) [Streptococcus sp. FSL K6-1323]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=986319 NST80_RS04300 WP_002891134.1 974631..975305(+) (ciaR) [Streptococcus sp. FSL K6-1323]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGCCTTTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT
TACCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGATGATAAGGGTCATGGCTTTGAACTGGGTGCAGATGACTATCTAACCAAACCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGATCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAACGTGATTTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACGGT
ATCAGTTGTTGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: J7TS49

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae D39	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae R6	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae TIGR4	87.444	99.554	0.871
ciaR	Streptococcus mutans UA159	86.607	100	0.866
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362