Detailed information NTG0098571

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: R8623_RS02515
• Genome accession: NZ_AP026928
• Coordinates: 492904..493491 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain PZ900700406
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 487904..498491

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8623_RS02495 (PC0401_04860)	-	488366..489706 (+)	1341	WP_001017642.1	sensor histidine kinase	-
R8623_RS02500 (PC0401_04870)	blpC	489777..489905 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
R8623_RS02505 (PC0401_04880)	-	489962..491323 (-)	1362	WP_001069060.1	bacteriocin secretion accessory protein	-
R8623_RS02510 (PC0401_04890)	comA/nlmT	491334..493010 (-)	1677	WP_215729172.1	peptide cleavage/export ABC transporter	Regulator
R8623_RS02515 (PC0401_04900)	comA/nlmT	492904..493491 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
R8623_RS02520 (PC0401_04910)	blpI	493780..493977 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
R8623_RS02525 (PC0401_04920)	blpJ	494444..494713 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
R8623_RS02530 (PC0401_04930)	blpK	494782..495030 (+)	249	WP_000379965.1	bacteriocin-like peptide BlpK	-
R8623_RS02535 (PC0401_04940)	cipB	495274..495423 (+)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
R8623_RS10930	-	495459..495524 (+)	66	Protein_499	ComC/BlpC family peptide pheromone/bacteriocin	-
R8623_RS02540	-	495527..495646 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
R8623_RS02545 (PC0401_04960)	-	496127..496485 (+)	359	Protein_501	immunity protein	-
R8623_RS02550 (PC0401_04980)	-	497114..497497 (+)	384	WP_000877381.1	hypothetical protein	-
R8623_RS02555 (PC0401_04990)	-	497549..498238 (+)	690	WP_000760532.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=98571 R8623_RS02515 WP_000205166.1 492904..493491(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700406]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=98571 R8623_RS02515 WP_000205166.1 492904..493491(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700406]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497