Detailed information NTG0098493

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: R8611_RS02445
• Genome accession: NZ_AP026927
• Coordinates: 483824..484411 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain PZ900700178
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 478824..489411

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8611_RS02425 (PC0174_04760)	-	479286..480626 (+)	1341	WP_001099893.1	sensor histidine kinase	-
R8611_RS02430 (PC0174_04770)	blpC	480670..480825 (-)	156	WP_000358811.1	quorum-sensing system pheromone BlpC	-
R8611_RS02435 (PC0174_04780)	-	480882..482243 (-)	1362	WP_033705510.1	bacteriocin secretion accessory protein	-
R8611_RS02440 (PC0174_04790)	comA/nlmT	482254..483930 (-)	1677	WP_307774337.1	peptide cleavage/export ABC transporter	Regulator
R8611_RS02445 (PC0174_04800)	comA/nlmT	483824..484411 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
R8611_RS02450 (PC0174_04810)	blpM	484729..484983 (+)	255	WP_033705509.1	two-peptide bacteriocin subunit BlpM	-
R8611_RS02455 (PC0174_04820)	blpN	484999..485202 (+)	204	WP_001099490.1	two-peptide bacteriocin subunit BlpN	-
R8611_RS02460 (PC0174_04830)	cipB	485446..485595 (+)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
R8611_RS10745	-	485631..485696 (+)	66	Protein_486	ComC/BlpC family peptide pheromone/bacteriocin	-
R8611_RS02465	-	485699..485818 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
R8611_RS02470 (PC0174_04850)	-	486286..486657 (+)	372	WP_033705507.1	hypothetical protein	-
R8611_RS02475	-	486818..487787 (+)	970	Protein_489	thioredoxin domain-containing protein	-
R8611_RS02480 (PC0174_04880)	-	488034..488267 (+)	234	WP_033705506.1	bacteriocin class II family protein	-
R8611_RS02485 (PC0174_04890)	-	488299..488988 (+)	690	WP_050199695.1	CPBP family intramembrane glutamic endopeptidase	-
R8611_RS02490 (PC0174_04900)	blpZ	489030..489278 (+)	249	WP_000276506.1	immunity protein BlpZ	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=98493 R8611_RS02445 WP_000205166.1 483824..484411(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700178]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=98493 R8611_RS02445 WP_000205166.1 483824..484411(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700178]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGAAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497