Detailed information NTG0098412

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: R8559_RS02830
• Genome accession: NZ_AP026926
• Coordinates: 535700..536287 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain PZ900700119
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 530700..541287

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8559_RS02810 (PC0116_05520)	-	531162..532502 (+)	1341	WP_001017643.1	sensor histidine kinase	-
R8559_RS02815 (PC0116_05530)	blpC	532573..532701 (-)	129	WP_000358815.1	quorum-sensing system pheromone BlpC	-
R8559_RS02820 (PC0116_05540)	-	532758..534119 (-)	1362	Protein_555	bacteriocin secretion accessory protein	-
R8559_RS02825 (PC0116_05560)	comA/nlmT	534130..535806 (-)	1677	WP_196299874.1	peptide cleavage/export ABC transporter	Regulator
R8559_RS02830 (PC0116_05570)	comA/nlmT	535700..536287 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
R8559_RS02835 (PC0116_05580)	blpI	536569..536766 (+)	198	WP_001093261.1	bacteriocin-like peptide BlpI	-
R8559_RS02840 (PC0116_05600)	blpJ	537233..537502 (+)	270	WP_001093248.1	bacteriocin-like peptide BlpJ	-
R8559_RS02845 (PC0116_05610)	blpU	537571..537801 (+)	231	WP_000379967.1	bacteriocin-like peptide BlpU	-
R8559_RS02850	-	537804..537923 (+)	120	WP_000346298.1	PncF family bacteriocin immunity protein	-
R8559_RS02855 (PC0116_05620)	-	538220..538384 (+)	165	WP_000727118.1	hypothetical protein	-
R8559_RS02860 (PC0116_05630)	-	538381..538785 (+)	405	WP_000846944.1	hypothetical protein	-
R8559_RS02865	-	538988..539793 (+)	806	Protein_564	IS5 family transposase	-
R8559_RS02870 (PC0116_05660)	blpM	539943..540197 (+)	255	WP_000379877.1	two-peptide bacteriocin subunit BlpM	-
R8559_RS02875 (PC0116_05670)	blpN	540213..540416 (+)	204	WP_001099492.1	two-peptide bacteriocin subunit BlpN	-
R8559_RS02880 (PC0116_05680)	cipB	540660..540809 (+)	150	WP_001820573.1	bacteriocin-like peptide BlpO	Regulator
R8559_RS02885	-	540913..541032 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=98412 R8559_RS02830 WP_000205166.1 535700..536287(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700119]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=98412 R8559_RS02830 WP_000205166.1 535700..536287(-) (comA/nlmT) [Streptococcus pneumoniae strain PZ900700119]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497