Detailed information NTG0098264

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: R8635_RS06610
• Genome accession: NZ_AP026924
• Coordinates: 1268576..1269226 (-)
• Length: 216 a.a.
• NCBI ID: WP_000387331.1
• Uniprot ID: A0A0E7VQD3
• Organism: Streptococcus pneumoniae strain PZ900700063
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 1263576..1274226

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8635_RS06590 (PC0062_13080)	-	1264181..1265362 (-)	1182	WP_000655958.1	ABC transporter permease	-
R8635_RS06595 (PC0062_13090)	-	1265366..1265953 (-)	588	WP_000933542.1	ATP-binding cassette domain-containing protein	-
R8635_RS06600 (PC0062_13100)	-	1265985..1266173 (-)	189	WP_001809102.1	hypothetical protein	-
R8635_RS06605 (PC0062_13110)	comEC/celB	1266352..1268592 (-)	2241	WP_000942403.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
R8635_RS06610 (PC0062_13120)	comEA/celA/cilE	1268576..1269226 (-)	651	WP_000387331.1	ComEA family DNA-binding protein	Machinery gene
R8635_RS06615 (PC0062_13130)	-	1269294..1269863 (-)	570	WP_000443751.1	GNAT family N-acetyltransferase	-
R8635_RS06620 (PC0062_13140)	-	1269971..1270975 (-)	1005	WP_050096410.1	PhoH family protein	-
R8635_RS06625 (PC0062_13150)	-	1271061..1271276 (-)	216	WP_001232082.1	YozE family protein	-
R8635_RS06630 (PC0062_13160)	cvfB	1271285..1272139 (-)	855	WP_001095445.1	RNA-binding virulence regulatory protein CvfB	-
R8635_RS06635 (PC0062_13170)	frr	1272199..1272756 (-)	558	WP_000024409.1	ribosome recycling factor	-
R8635_RS06640 (PC0062_13180)	pyrH	1272765..1273502 (-)	738	WP_000002997.1	UMP kinase	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23203.57 Da
• Isoelectric Point: 5.5171

>NTDB_id=98264 R8635_RS06610 WP_000387331.1 1268576..1269226(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain PZ900700063]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQAEVAAVSKDLVSEKEVNKEEKEEPLEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=98264 R8635_RS06610 WP_000387331.1 1268576..1269226(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain PZ900700063]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTAAAGGAAACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCCCTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• SLBB domain (SLBB) (76-126)

• Helix-hairpin-helix motif (HHH_3) (151-214)

3D structure

• AlphaFold DB: A0A0E7VQD3

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae Rx1	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae D39	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae R6	99.537	100	0.995
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	97.685	100	0.977
comEA/celA/cilE	Streptococcus mitis NCTC 12261	96.296	100	0.963
comEA/celA/cilE	Streptococcus mitis SK321	90.741	100	0.907
comEA	Lactococcus lactis subsp. cremoris KW2	43.612	100	0.458
comEA	Bacillus subtilis subsp. subtilis str. 168	41.579	87.963	0.366
comEA	Latilactobacillus sakei subsp. sakei 23K	33.476	100	0.361