Detailed information
Bioinformatically predicted
Overview
| Name | comB | Type | Regulator |
| Locus tag | R8635_RS00485 | Genome accession | NZ_AP026924 |
| Coordinates | 81640..82989 (+) | Length | 449 a.a. |
| NCBI ID | WP_000801620.1 | Uniprot ID | - |
| Organism | Streptococcus pneumoniae strain PZ900700063 | ||
| Function | transport of ComC (predicted from homology) Competence regulation |
||
Related MGE
Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.
Gene-MGE association summary
| MGE type | MGE coordinates | Gene coordinates | Relative position | Distance (bp) |
|---|---|---|---|---|
| Prophage | 12174..93094 | 81640..82989 | within | 0 |
Gene organization within MGE regions
Location: 12174..93094
| Locus tag | Gene name | Coordinates (strand) | Size (bp) | Protein ID | Product | Description |
|---|---|---|---|---|---|---|
| R8635_RS00065 (PC0062_00130) | ftsH | 12174..14132 (+) | 1959 | WP_000744557.1 | ATP-dependent zinc metalloprotease FtsH | - |
| R8635_RS00070 (PC0062_00140) | comX/comX2 | 14254..14733 (+) | 480 | WP_000588873.1 | sigma-70 family RNA polymerase sigma factor | Regulator |
| R8635_RS00105 | - | 20235..21016 (-) | 782 | Protein_14 | transposase | - |
| R8635_RS00110 (PC0062_00160) | comW | 21282..21518 (+) | 237 | WP_000939545.1 | sigma(X)-activator ComW | Regulator |
| R8635_RS00115 (PC0062_00170) | - | 21749..23035 (+) | 1287 | WP_000205044.1 | adenylosuccinate synthase | - |
| R8635_RS00120 (PC0062_00180) | tadA | 23236..23703 (+) | 468 | WP_000291870.1 | tRNA adenosine(34) deaminase TadA | - |
| R8635_RS00130 (PC0062_00190) | - | 23912..25048 (-) | 1137 | WP_224757251.1 | site-specific integrase | - |
| R8635_RS00135 (PC0062_00200) | - | 25173..25523 (-) | 351 | WP_001020945.1 | hypothetical protein | - |
| R8635_RS00140 (PC0062_00210) | - | 25537..25917 (-) | 381 | WP_000136430.1 | ImmA/IrrE family metallo-endopeptidase | - |
| R8635_RS00145 (PC0062_00220) | - | 25939..26295 (-) | 357 | WP_000153672.1 | helix-turn-helix domain-containing protein | - |
| R8635_RS00150 (PC0062_00230) | - | 26571..26756 (+) | 186 | WP_000638668.1 | helix-turn-helix transcriptional regulator | - |
| R8635_RS00155 (PC0062_00240) | - | 26758..27474 (+) | 717 | WP_001004042.1 | phage antirepressor KilAC domain-containing protein | - |
| R8635_RS00160 (PC0062_00250) | - | 27521..27787 (+) | 267 | WP_001865194.1 | hypothetical protein | - |
| R8635_RS00165 (PC0062_00270) | - | 28135..28398 (+) | 264 | WP_001814284.1 | transcriptional regulator | - |
| R8635_RS00170 (PC0062_00280) | - | 28630..28896 (+) | 267 | WP_000450965.1 | hypothetical protein | - |
| R8635_RS00175 (PC0062_00290) | - | 28980..29432 (+) | 453 | WP_055310816.1 | hypothetical protein | - |
| R8635_RS00180 (PC0062_00300) | - | 29438..30085 (+) | 648 | WP_023396071.1 | ERF family protein | - |
| R8635_RS00185 (PC0062_00310) | - | 30088..31080 (+) | 993 | WP_075223585.1 | DUF1351 domain-containing protein | - |
| R8635_RS00190 (PC0062_00320) | - | 31102..31278 (+) | 177 | WP_001203349.1 | hypothetical protein | - |
| R8635_RS00195 (PC0062_00330) | ssb | 31268..31843 (+) | 576 | WP_050149695.1 | single-stranded DNA-binding protein | Machinery gene |
| R8635_RS00200 (PC0062_00340) | - | 31857..32177 (+) | 321 | WP_224757151.1 | hypothetical protein | - |
| R8635_RS00205 (PC0062_00350) | - | 32192..32395 (+) | 204 | WP_000161126.1 | hypothetical protein | - |
| R8635_RS00210 (PC0062_00360) | - | 32423..32602 (+) | 180 | Protein_34 | hypothetical protein | - |
| R8635_RS00215 (PC0062_00370) | - | 32619..32831 (+) | 213 | WP_001286809.1 | crAss001_48 related protein | - |
| R8635_RS00220 (PC0062_00380) | - | 32842..33243 (+) | 402 | WP_000667209.1 | hypothetical protein | - |
| R8635_RS00225 (PC0062_00390) | - | 33245..33451 (+) | 207 | WP_075223584.1 | hypothetical protein | - |
| R8635_RS00230 (PC0062_00400) | - | 33500..33817 (+) | 318 | WP_000969685.1 | hypothetical protein | - |
| R8635_RS00235 (PC0062_00410) | - | 33819..34334 (+) | 516 | WP_001021768.1 | DUF1642 domain-containing protein | - |
| R8635_RS00240 (PC0062_00420) | - | 34335..34547 (+) | 213 | WP_000160161.1 | hypothetical protein | - |
| R8635_RS00245 (PC0062_00430) | - | 34544..34915 (+) | 372 | WP_001247149.1 | hypothetical protein | - |
| R8635_RS00250 (PC0062_00440) | - | 34936..35229 (+) | 294 | WP_000194856.1 | hypothetical protein | - |
| R8635_RS00255 (PC0062_00450) | - | 35229..35621 (+) | 393 | WP_000162611.1 | hypothetical protein | - |
| R8635_RS00260 (PC0062_00460) | - | 35687..36781 (+) | 1095 | WP_000425573.1 | DUF4417 domain-containing protein | - |
| R8635_RS00265 (PC0062_00470) | - | 36762..37508 (+) | 747 | WP_000057535.1 | hypothetical protein | - |
| R8635_RS00270 (PC0062_00480) | - | 37712..38167 (+) | 456 | WP_001136855.1 | KGG domain-containing protein | - |
| R8635_RS00275 (PC0062_00490) | - | 38157..39467 (+) | 1311 | WP_050085301.1 | PBSX family phage terminase large subunit | - |
| R8635_RS00280 (PC0062_00500) | - | 39480..41048 (+) | 1569 | WP_024475368.1 | phage portal protein | - |
| R8635_RS00285 (PC0062_00510) | - | 41035..41208 (+) | 174 | WP_000169861.1 | hypothetical protein | - |
| R8635_RS00290 (PC0062_00520) | - | 41251..42402 (+) | 1152 | WP_000730219.1 | phage minor capsid protein | - |
| R8635_RS00295 (PC0062_00530) | - | 42541..43104 (+) | 564 | WP_050222512.1 | phage scaffolding protein | - |
| R8635_RS00300 (PC0062_00540) | - | 43122..44003 (+) | 882 | WP_001139820.1 | hypothetical protein | - |
| R8635_RS00305 (PC0062_00550) | - | 44014..44247 (+) | 234 | WP_001240344.1 | hypothetical protein | - |
| R8635_RS00310 (PC0062_00560) | - | 44290..44682 (+) | 393 | WP_000221836.1 | hypothetical protein | - |
| R8635_RS00315 (PC0062_00570) | - | 44672..45043 (+) | 372 | WP_000565934.1 | putative minor capsid protein | - |
| R8635_RS00320 (PC0062_00580) | - | 45043..45387 (+) | 345 | WP_000020371.1 | minor capsid protein | - |
| R8635_RS00325 (PC0062_00590) | - | 45387..45794 (+) | 408 | WP_001208881.1 | minor capsid protein | - |
| R8635_RS00330 (PC0062_00600) | - | 45791..46240 (+) | 450 | WP_050198117.1 | phage tail tube protein | - |
| R8635_RS00335 (PC0062_00610) | - | 46305..46793 (+) | 489 | WP_050216326.1 | hypothetical protein | - |
| R8635_RS00340 (PC0062_00620) | - | 46806..47375 (+) | 570 | WP_000062048.1 | Gp15 family bacteriophage protein | - |
| R8635_RS00345 (PC0062_00630) | - | 47368..50649 (+) | 3282 | WP_075223583.1 | tape measure protein | - |
| R8635_RS00350 (PC0062_00640) | - | 50646..52160 (+) | 1515 | WP_050221514.1 | distal tail protein Dit | - |
| R8635_RS00355 (PC0062_00650) | - | 52162..59334 (+) | 7173 | WP_317657546.1 | phage tail protein | - |
| R8635_RS00360 (PC0062_00660) | - | 59346..61394 (+) | 2049 | WP_075223615.1 | DUF859 family phage minor structural protein | - |
| R8635_RS00365 (PC0062_00670) | - | 61454..61717 (+) | 264 | WP_000922101.1 | hypothetical protein | - |
| R8635_RS00370 (PC0062_00680) | - | 61727..62143 (+) | 417 | WP_000687457.1 | phage holin family protein | - |
| R8635_RS00375 (PC0062_00690) | - | 62147..62482 (+) | 336 | WP_075223614.1 | phage holin | - |
| R8635_RS00380 (PC0062_00700) | - | 62485..63441 (+) | 957 | WP_075223617.1 | N-acetylmuramoyl-L-alanine amidase family protein | - |
| R8635_RS00385 (PC0062_00710) | - | 63724..64167 (+) | 444 | WP_000701992.1 | dUTP diphosphatase | - |
| R8635_RS00390 (PC0062_00720) | - | 64169..64684 (+) | 516 | WP_317657561.1 | histidine phosphatase family protein | - |
| R8635_RS00395 (PC0062_00730) | radA | 64698..66059 (+) | 1362 | WP_074017595.1 | DNA repair protein RadA | Machinery gene |
| R8635_RS00400 (PC0062_00740) | - | 66132..66629 (+) | 498 | WP_001809263.1 | carbonic anhydrase | - |
| R8635_RS00405 (PC0062_00750) | - | 66654..67468 (+) | 815 | Protein_73 | PrsW family intramembrane metalloprotease | - |
| R8635_RS00410 (PC0062_00760) | - | 67613..68581 (+) | 969 | WP_000010163.1 | ribose-phosphate diphosphokinase | - |
| R8635_RS00415 | - | 68715..68996 (-) | 282 | Protein_75 | ISL3 family transposase | - |
| R8635_RS00420 | - | 69123..70030 (-) | 908 | Protein_76 | Rpn family recombination-promoting nuclease/putative transposase | - |
| R8635_RS00425 (PC0062_00800) | polA | 70281..72914 (+) | 2634 | WP_061459569.1 | DNA polymerase I | - |
| R8635_RS00430 (PC0062_00810) | - | 72999..73436 (+) | 438 | WP_000076479.1 | CoA-binding protein | - |
| R8635_RS00435 | - | 73477..73647 (+) | 171 | WP_256948191.1 | hypothetical protein | - |
| R8635_RS00440 (PC0062_00820) | - | 73666..74676 (-) | 1011 | WP_050203163.1 | YeiH family protein | - |
| R8635_RS00445 (PC0062_00830) | - | 74825..75994 (+) | 1170 | WP_000366342.1 | pyridoxal phosphate-dependent aminotransferase | - |
| R8635_RS00450 (PC0062_00840) | recO | 75991..76761 (+) | 771 | WP_000616164.1 | DNA repair protein RecO | - |
| R8635_RS00455 (PC0062_00850) | plsX | 76758..77750 (+) | 993 | WP_000717458.1 | phosphate acyltransferase PlsX | - |
| R8635_RS00460 (PC0062_00860) | - | 77756..77989 (+) | 234 | WP_000136447.1 | acyl carrier protein | - |
| R8635_RS00465 | - | 78026..78326 (+) | 301 | Protein_85 | transposase family protein | - |
| R8635_RS00470 (PC0062_00870) | blpU | 78529..78759 (+) | 231 | WP_001093075.1 | bacteriocin-like peptide BlpU | - |
| R8635_RS00475 | - | 78762..78887 (+) | 126 | WP_000346297.1 | PncF family bacteriocin immunity protein | - |
| R8635_RS00480 (PC0062_00880) | comA | 79474..81627 (+) | 2154 | WP_268217970.1 | peptide cleavage/export ABC transporter ComA | Regulator |
| R8635_RS00485 (PC0062_00890) | comB | 81640..82989 (+) | 1350 | WP_000801620.1 | competence pheromone export protein ComB | Regulator |
| R8635_RS00490 (PC0062_00900) | purC | 83159..83866 (+) | 708 | WP_000043300.1 | phosphoribosylaminoimidazolesuccinocarboxamide synthase | - |
| R8635_RS00495 | - | 83877..84011 (+) | 135 | WP_000429437.1 | hypothetical protein | - |
| R8635_RS00500 (PC0062_00910) | - | 84068..87793 (+) | 3726 | WP_000361192.1 | phosphoribosylformylglycinamidine synthase | - |
| R8635_RS00505 (PC0062_00920) | purF | 87886..89328 (+) | 1443 | WP_000220627.1 | amidophosphoribosyltransferase | - |
| R8635_RS00510 (PC0062_00930) | purM | 89365..90387 (+) | 1023 | WP_000182575.1 | phosphoribosylformylglycinamidine cyclo-ligase | - |
| R8635_RS00515 (PC0062_00940) | purN | 90384..90929 (+) | 546 | WP_000717501.1 | phosphoribosylglycinamide formyltransferase | - |
| R8635_RS00520 (PC0062_00950) | - | 91013..91522 (+) | 510 | WP_023396542.1 | VanZ family protein | - |
| R8635_RS00525 (PC0062_00960) | purH | 91547..93094 (+) | 1548 | WP_000167081.1 | bifunctional phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase | - |
Sequence
Protein
Download Length: 449 a.a. Molecular weight: 49607.54 Da Isoelectric Point: 5.3895
>NTDB_id=98244 R8635_RS00485 WP_000801620.1 81640..82989(+) (comB) [Streptococcus pneumoniae strain PZ900700063]
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTVKSAIETGASLAGQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAEINLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE
MKPEFLESAEFYNRRYHNFSSSVIVPMALLLVFLLGFATVAEKEMSLSTRATVEPSRILANIQSTSNNRILVNHLEENKL
VKKGDLLVQYQEGAEGVQAESYASQLDMLKDQKKQLEYLQKSLQEGENHFPEEDKFGYQATFRDYISQAGSLRASTSQQN
ETIASQNAAASQTQAEIGNLISQTEAKIRDYQTVKSAIETGASLAGQNLAYSLYQSYKSQGEENPQTKVQAVAQVEAQIS
QLESSLATYRVQYAGSGTQQAYASGLSSQLESLKSQHLAKVGQELTLLAQKILEAESGKKVQGNLLDKGKITASEDGVLH
LNPETSDSSMVAEGALLAQLYPSLEREGKAKLTAYLSSKDVARIKVGDSVRYTTTHDAGNQLFLDSTITSIDATATKTEK
GNFFKIEAEINLTSEQAEKLRYGVEGRLQMITGKKSYLRYYLDQFLNKE
Nucleotide
Download Length: 1350 bp
>NTDB_id=98244 R8635_RS00485 WP_000801620.1 81640..82989(+) (comB) [Streptococcus pneumoniae strain PZ900700063]
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAAAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGTTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGCCGGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACACTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATCTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCAAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCCTATCTAAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTTCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGATTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTACGGGGTGGAAGGCCG
TCTACAGATGATTACGGGCAAGAAAAGTTATCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA
ATGAAACCAGAATTTTTAGAAAGTGCGGAGTTTTATAATCGTCGTTACCATAATTTTTCCAGTAGTGTGATTGTACCCAT
GGCCCTTCTGCTCGTGTTTTTACTTGGCTTTGCAACTGTTGCAGAAAAGGAGATGAGTTTGTCCACTAGAGCTACTGTCG
AACCTAGTCGTATCCTTGCAAATATCCAGTCAACTAGCAACAATCGTATTCTTGTCAATCATTTGGAAGAAAATAAGCTG
GTTAAGAAGGGGGATCTTTTGGTTCAATACCAAGAAGGGGCAGAGGGTGTCCAAGCGGAGTCCTATGCCAGTCAGTTGGA
CATGCTAAAGGATCAAAAAAAGCAATTGGAGTATCTGCAAAAGAGCCTGCAAGAAGGGGAGAACCACTTTCCAGAGGAGG
ATAAGTTTGGCTACCAAGCCACCTTTCGCGACTACATCAGTCAAGCAGGCAGTCTTAGGGCTAGTACATCGCAACAAAAT
GAGACCATCGCGTCCCAGAATGCAGCAGCTAGCCAAACCCAAGCCGAAATCGGCAACCTCATCAGTCAAACAGAGGCTAA
AATTCGCGATTACCAGACAGTTAAGTCAGCTATTGAAACAGGTGCTTCCTTGGCCGGTCAGAATCTAGCCTACTCTCTTT
ACCAGTCCTACAAGTCTCAGGGCGAGGAAAATCCCCAAACTAAGGTTCAGGCAGTTGCACAGGTTGAAGCACAGATTTCT
CAGTTAGAATCTAGTCTTGCTACTTACCGTGTCCAGTATGCAGGTTCAGGTACCCAGCAAGCCTATGCGTCAGGGTTAAG
CAGTCAATTGGAATCCCTTAAATCCCAACACTTGGCAAAGGTTGGTCAGGAATTGACCCTTCTAGCCCAGAAAATCTTGG
AGGCAGAGTCAGGTAAGAAGGTACAGGGAAATCTTTTAGACAAGGGGAAAATTACGGCAAGTGAGGATGGGGTGCTTCAT
CTTAATCCTGAGACCAGTGATTCTAGCATGGTTGCAGAAGGTGCCCTACTAGCCCAACTTTATCCATCTTTGGAAAGAGA
AGGGAAAGCCAAACTCACAGCCTATCTAAGTTCAAAAGATGTAGCAAGAATCAAGGTCGGTGATTCTGTTCGCTATACTA
CGACTCATGATGCCGGGAATCAACTTTTTCTAGATTCTACTATTACAAGTATTGATGCGACAGCTACTAAGACTGAGAAA
GGGAATTTCTTTAAAATCGAGGCGGAGATTAATCTAACTTCGGAGCAGGCTGAAAAACTTAGGTACGGGGTGGAAGGCCG
TCTACAGATGATTACGGGCAAGAAAAGTTATCTACGTTATTATTTGGATCAATTTTTGAACAAAGAGTAA
3D structure
| Source | ID | Structure |
|---|
Similar proteins
Only experimentally validated proteins are listed.
| Protein | Organism | Identities (%) | Coverage (%) | Ha-value |
|---|---|---|---|---|
| comB | Streptococcus pneumoniae TIGR4 |
99.109 |
100 |
0.991 |
| comB | Streptococcus pneumoniae D39 |
98.886 |
100 |
0.989 |
| comB | Streptococcus pneumoniae R6 |
98.886 |
100 |
0.989 |
| comB | Streptococcus pneumoniae Rx1 |
98.886 |
100 |
0.989 |
| comB | Streptococcus mitis SK321 |
94.655 |
100 |
0.947 |
| comB | Streptococcus mitis NCTC 12261 |
94.209 |
100 |
0.942 |
| comB | Streptococcus gordonii str. Challis substr. CH1 |
55.556 |
100 |
0.557 |