Detailed information NTG0098108

Bioinformatically predicted

Overview

• Name: dprA/cilB/dalA
• Type: Machinery gene
• Locus tag: R8586_RS06140
• Genome accession: NZ_AP026922
• Coordinates: 1191944..1192792 (-)
• Length: 282 a.a.
• NCBI ID: WP_000705306.1
• Uniprot ID: A0A098Z7D2
• Organism: Streptococcus pneumoniae strain PZ900700038
• Function: ssDNA binding; loading RecA onto ssDNA; competence shut-off (predicted from homology) DNA processing Competence regulation

Genomic Context

Location: 1186944..1197792

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8586_RS06120 (PC0038_12160)	-	1187183..1187542 (-)	360	WP_001220357.1	YbaN family protein	-
R8586_RS06125 (PC0038_12170)	topA	1187763..1189850 (-)	2088	WP_000179643.1	type I DNA topoisomerase	-
R8586_RS06130 (PC0038_12180)	-	1190017..1191060 (-)	1044	WP_001812883.1	TIGR00341 family protein	-
R8586_RS06135	-	1191638..1191760 (+)	123	WP_001814242.1	hypothetical protein	-
R8586_RS06140 (PC0038_12190)	dprA/cilB/dalA	1191944..1192792 (-)	849	WP_000705306.1	DNA-processing protein DprA	Machinery gene
R8586_RS06145 (PC0038_12200)	-	1192890..1193579 (-)	690	WP_000643975.1	sugar phosphate nucleotidyltransferase	-
R8586_RS06150 (PC0038_12210)	-	1193591..1194469 (-)	879	WP_000837609.1	DMT family transporter	-
R8586_RS06155 (PC0038_12220)	licA	1194459..1195328 (-)	870	WP_000411210.1	choline kinase LicA	-
R8586_RS06160 (PC0038_12230)	-	1195345..1196367 (-)	1023	WP_000609887.1	ribitol-5-phosphate dehydrogenase	-
R8586_RS06165 (PC0038_12240)	-	1196372..1197079 (-)	708	WP_000638507.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-

Sequence

Protein

• Length: 282 a.a.
• Molecular weight: 31062.72 Da
• Isoelectric Point: 5.4047

>NTDB_id=98108 R8586_RS06140 WP_000705306.1 1191944..1192792(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain PZ900700038]
MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDC
YPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
TIAVIGTGLDVFYPKANKRLQDYIGNDHLVLSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEE
GRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEF

Nucleotide

• Length: 849 bp

>NTDB_id=98108 R8586_RS06140 WP_000705306.1 1191944..1192792(-) (dprA/cilB/dalA) [Streptococcus pneumoniae strain PZ900700038]
ATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAGATTTTGAAAGTTCTAGAATA
CGGTGAAAATGTTGATCAGGAGCTTTTGTTGGGTGATATTGCAGATATATCAGGTTGCCGTAATCCAGCCGTTTTTATGG
AACGTTATTTTCAGATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCATCTTTCTCTATTTTAGATGACTGT
TATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAAGGGAAATCTTGACCTCCTGAAATTCCC
GAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAAATCAGTTGAAAAAGTCATTCAAGGCTTGGAAA
ATGAACTGGTTATTGTCAGTGGTCTGGCCAAGGGCATTGACACAGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAA
ACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTATCCTAAAGCCAATAAACGCTTGCAAGACTACATCGGCAATGA
CCATCTGGTTCTAAGTGAATATGGACCTGGCGAACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTG
GACTTTGTCGTGGTGTGATTGTAGCAGAGGCTAAGATGCGTTCAGGTAGTCTCATTACGTGTGAGCGAGCAATGGAAGAA
GGACGCGATGTCTTTGCTATTCCTGGTAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGC
AAAATTGGTCACCAGTGGGCAAGATGTTCTTGCGGAATTTGAATTTTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (75-271)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (3-64)

3D structure

• AlphaFold DB: A0A098Z7D2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	100	100	1
dprA/cilB/dalA	Streptococcus pneumoniae D39	100	100	1
dprA/cilB/dalA	Streptococcus pneumoniae R6	100	100	1
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	100	100	1
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	98.582	100	0.986
dprA/cilB/dalA	Streptococcus mitis SK321	97.872	100	0.979
dprA	Streptococcus mutans UA159	63.214	99.291	0.628
dprA	Lactococcus lactis subsp. cremoris KW2	55.714	99.291	0.553
dprA	Staphylococcus aureus N315	37.809	100	0.379
dprA	Haemophilus influenzae Rd KW20	38.202	94.681	0.362