Detailed information NTG0098102

Bioinformatically predicted

Overview

• Name: comEA/celA/cilE
• Type: Machinery gene
• Locus tag: R8586_RS04655
• Genome accession: NZ_AP026922
• Coordinates: 901934..902584 (+)
• Length: 216 a.a.
• NCBI ID: WP_000387352.1
• Uniprot ID: A0A4J1SCX2
• Organism: Streptococcus pneumoniae strain PZ900700038
• Function: dsDNA binding to the cell surface (predicted from homology) DNA binding and uptake

Genomic Context

Location: 896934..907584

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8586_RS04625 (PC0038_09170)	-	897430..897645 (+)	216	WP_001232078.1	YozE family protein	-
R8586_RS04630 (PC0038_09180)	-	897731..898699 (+)	969	WP_000658181.1	PhoH family protein	-
R8586_RS04635 (PC0038_09190)	-	898879..899379 (+)	501	WP_000566988.1	GNAT family N-acetyltransferase	-
R8586_RS04640 (PC0038_09200)	-	899382..899708 (+)	327	Protein_918	TfoX/Sxy family protein	-
R8586_RS04645 (PC0038_09220)	ald	900009..901120 (-)	1112	Protein_919	alanine dehydrogenase	-
R8586_RS04650 (PC0038_09230)	-	901297..901866 (+)	570	WP_000443745.1	GNAT family N-acetyltransferase	-
R8586_RS04655 (PC0038_09240)	comEA/celA/cilE	901934..902584 (+)	651	WP_000387352.1	helix-hairpin-helix domain-containing protein	Machinery gene
R8586_RS04660 (PC0038_09250)	comEC/celB	902568..904808 (+)	2241	WP_000942422.1	DNA internalization-related competence protein ComEC/Rec2	Machinery gene
R8586_RS04665 (PC0038_09260)	-	904988..905176 (+)	189	WP_010976492.1	hypothetical protein	-
R8586_RS04670 (PC0038_09270)	-	905208..905795 (+)	588	WP_000933542.1	ATP-binding cassette domain-containing protein	-
R8586_RS04675 (PC0038_09280)	-	905799..906974 (+)	1176	WP_000655940.1	hypothetical protein	-

Sequence

Protein

• Length: 216 a.a.
• Molecular weight: 23085.30 Da
• Isoelectric Point: 6.0661

>NTDB_id=98102 R8586_RS04655 WP_000387352.1 901934..902584(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain PZ900700038]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTSVKETNLQAEVAAVSKDSSTGKEVNKEEKEEPVEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSTSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGAKTIEKLKDYVTVD

Nucleotide

• Length: 651 bp

>NTDB_id=98102 R8586_RS04655 WP_000387352.1 901934..902584(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain PZ900700038]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGAGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACATCTGTCAAAGAGACGAATTTGCAGGCTGAAGTTGCAGCTGTTTCCAAGGACT
CATCGACCGGAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCAGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAACAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATTGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGCCAAGACCATAGAAAAACTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

• Helix-hairpin-helix motif (HHH_3) (151-214)

• SLBB domain (SLBB) (76-126)

3D structure

• AlphaFold DB: A0A4J1SCX2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comEA/celA/cilE	Streptococcus pneumoniae TIGR4	97.685	100	0.977
comEA/celA/cilE	Streptococcus pneumoniae Rx1	95.833	100	0.958
comEA/celA/cilE	Streptococcus pneumoniae D39	95.833	100	0.958
comEA/celA/cilE	Streptococcus pneumoniae R6	95.833	100	0.958
comEA/celA/cilE	Streptococcus mitis NCTC 12261	95.37	100	0.954
comEA/celA/cilE	Streptococcus mitis SK321	92.593	100	0.926
comEA	Lactococcus lactis subsp. cremoris KW2	44.053	100	0.463
comEA	Latilactobacillus sakei subsp. sakei 23K	34.335	100	0.37