Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   R8586_RS00230 Genome accession   NZ_AP026922
Coordinates   40626..42779 (+) Length   717 a.a.
NCBI ID   WP_000668299.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain PZ900700038     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 35626..47779
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8586_RS00195 (PC0038_00350) - 35977..37146 (+) 1170 WP_000366376.1 pyridoxal phosphate-dependent aminotransferase -
  R8586_RS00200 (PC0038_00360) recO 37143..37913 (+) 771 WP_000616164.1 DNA repair protein RecO -
  R8586_RS00205 (PC0038_00370) plsX 37910..38902 (+) 993 WP_000717456.1 phosphate acyltransferase PlsX -
  R8586_RS00210 (PC0038_00380) - 38908..39141 (+) 234 WP_000136449.1 acyl carrier protein -
  R8586_RS00215 - 39178..39478 (+) 301 Protein_35 transposase family protein -
  R8586_RS00220 (PC0038_00390) blpU 39681..39911 (+) 231 WP_001093075.1 bacteriocin-like peptide BlpU -
  R8586_RS00225 - 39914..40039 (+) 126 WP_000346297.1 PncF family bacteriocin immunity protein -
  R8586_RS00230 (PC0038_00400) comA 40626..42779 (+) 2154 WP_000668299.1 peptide cleavage/export ABC transporter ComA Regulator
  R8586_RS00235 (PC0038_00410) comB 42792..44141 (+) 1350 WP_000801618.1 competence pheromone export protein ComB Regulator
  R8586_RS00240 (PC0038_00420) purC 44312..45019 (+) 708 WP_000043304.1 phosphoribosylaminoimidazolesuccinocarboxamide synthase -
  R8586_RS00245 - 45021..45164 (+) 144 WP_050167432.1 hypothetical protein -

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80352.36 Da        Isoelectric Point: 6.2590

>NTDB_id=98085 R8586_RS00230 WP_000668299.1 40626..42779(+) (comA) [Streptococcus pneumoniae strain PZ900700038]
MKFGKRHYRPQVDQMDCGVASLAMVFGYYGSYYFLAHLRELAKTTMDGTTALGLVKVAEEIGFETRAIKADMTLFDLPDL
TFPFVAHVLKEGKLLHYYVVTGQDKDSIHIADPDPGVKLTKLPRERFEEEWTGVTLFMAPSPDYKPYKEQKNGLLSFIPI
LVKQRGLIANIVLATLLVTGINIVGSYYLQSIIDTYVPDQMRSTLGIISIGLVIVYILQQILSYAQEYLLLVLGQRLSID
VILSYIKHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSTVVIISLVLFSQNTNLFFMTLLALPIYTV
IIFAFMKPFEKMNRDTMEANAVLSSSIIEDINGIETIKSLTSESQRYQKIDKEFVDYLKKSFTYSRAESQQKALKKVAHL
LLNVGILWMGAVLVMDGKMSLGQLITYNTLLVYFTNPLENIINLQTKLQTAQVANNRLNEVYLVASEFEEKKTVEDLSLM
KGDMTFKQVHYKYGYGRDVLSDINLTVPQGSKVAFVGISGSGKTTLAKMMVNFYDPSQGEISLGGVNLNQIDKKALRQYI
NYLPQQPYVFNGTILENLLLGAKEGTTQEDILRAVELAEIREDIERMPLNYQTELTSDGAGISGGQRQRIALARALLTDA
PVLILDEATSSLDILTEKRIVDNLMALDKTLIFIAHRLTIAERTEKVVVLDQGKIVEEGKHADLLAQGGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=98085 R8586_RS00230 WP_000668299.1 40626..42779(+) (comA) [Streptococcus pneumoniae strain PZ900700038]
ATGAAATTTGGGAAACGTCACTATCGTCCGCAAGTGGATCAGATGGACTGCGGTGTAGCTTCATTAGCCATGGTTTTTGG
CTACTATGGTAGTTATTATTTTTTGGCTCACTTGCGAGAATTGGCTAAGACGACCATGGATGGGACGACGGCTTTGGGCT
TGGTCAAGGTGGCAGAGGAGATTGGTTTTGAGACGCGAGCCATTAAGGCGGATATGACGCTTTTTGACTTGCCGGATTTG
ACTTTTCCTTTTGTTGCCCATGTGCTTAAGGAAGGGAAATTGCTCCACTACTATGTGGTGACTGGGCAGGATAAGGATAG
CATTCATATTGCCGATCCAGATCCCGGGGTGAAGTTGACTAAACTGCCACGTGAGCGTTTTGAGGAAGAATGGACAGGAG
TGACTCTTTTTATGGCACCTAGTCCAGACTATAAGCCTTATAAGGAACAAAAAAATGGTCTGCTCTCTTTTATCCCTATA
TTAGTGAAGCAGCGTGGCTTGATTGCCAATATCGTTTTGGCAACACTCTTGGTAACCGGGATTAACATTGTGGGTTCTTA
TTATCTGCAGTCTATCATTGATACCTATGTGCCAGATCAGATGCGTTCGACACTAGGGATTATTTCTATTGGGCTAGTCA
TCGTCTACATCCTCCAGCAAATCTTGTCTTACGCTCAGGAGTATCTCTTGCTTGTTTTGGGGCAACGCTTGTCGATTGAC
GTGATTTTGTCCTATATCAAGCATGTTTTTCACCTCCCTATGTCCTTCTTTGCGACACGCAGGACAGGGGAGATCGTGTC
TCGTTTTACAGATGCTAACAGTATCATCGATGCGCTGGCTTCGACCATCCTTTCGATTTTCCTAGATGTGTCAACGGTTG
TCATTATTTCCCTTGTTCTATTTTCACAAAATACCAATCTCTTTTTCATGACTTTATTGGCGCTTCCTATCTACACAGTG
ATTATCTTTGCCTTTATGAAGCCGTTTGAAAAGATGAATCGGGATACCATGGAAGCCAATGCGGTTCTGTCTTCTTCTAT
CATTGAGGACATCAACGGTATTGAGACTATCAAGTCCTTGACCAGTGAAAGTCAGCGTTACCAAAAAATTGACAAGGAAT
TTGTGGATTATCTGAAGAAATCCTTTACCTATAGTCGAGCAGAGAGTCAGCAAAAGGCTCTGAAAAAGGTTGCCCATCTC
TTGCTTAATGTCGGCATTCTCTGGATGGGGGCTGTTCTGGTCATGGATGGCAAGATGAGTTTGGGGCAGTTGATTACCTA
TAATACCTTGCTGGTTTACTTTACCAATCCTTTGGAAAATATCATCAATCTGCAAACCAAGCTTCAGACAGCGCAGGTTG
CCAATAACCGTCTAAATGAAGTGTATCTAGTAGCTTCTGAGTTTGAGGAGAAGAAAACAGTTGAGGATTTGAGCTTGATG
AAGGGAGATATGACCTTCAAGCAGGTTCATTACAAGTATGGCTATGGTCGAGACGTCTTGTCGGATATCAATTTAACCGT
TCCCCAAGGGTCTAAGGTGGCTTTTGTGGGGATTTCAGGGTCAGGTAAGACGACTTTGGCCAAGATGATGGTTAATTTTT
ACGACCCAAGTCAAGGGGAGATTAGTCTGGGTGGTGTCAATCTCAATCAGATTGATAAAAAAGCCCTGCGCCAGTACATC
AACTATCTGCCTCAACAGCCCTATGTCTTTAACGGAACGATTTTGGAGAATCTTCTTTTGGGAGCCAAGGAGGGGACGAC
ACAGGAAGATATCTTACGGGCGGTCGAATTGGCAGAGATTCGAGAGGATATCGAGCGCATGCCACTGAATTATCAGACAG
AATTGACTTCGGATGGGGCAGGGATTTCAGGTGGTCAACGTCAGAGAATCGCTTTGGCGCGTGCTCTCTTGACAGATGCG
CCGGTCTTGATTTTGGATGAGGCGACTAGCAGTTTGGATATTTTGACAGAGAAGCGGATTGTCGATAATCTCATGGCTTT
GGACAAGACCTTGATTTTCATTGCTCACCGCTTGACTATTGCTGAGCGGACAGAGAAGGTGGTTGTCTTGGATCAGGGCA
AGATTGTCGAAGAAGGAAAGCATGCTGATTTGCTTGCACAGGGAGGCTTTTACGCCCATTTGGTCAATAGCTAG

Domains

Predicted by InterproScan.

ABC transporter transmembrane region (ABC_membrane)

(170-438)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter (ABC_tran)

(500-650)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus pneumoniae D39

99.582

100

0.996
  comA Streptococcus pneumoniae R6

99.582

100

0.996
  comA Streptococcus pneumoniae Rx1

99.582

100

0.996
  comA Streptococcus pneumoniae TIGR4

99.163

100

0.992
  comA Streptococcus mitis NCTC 12261

98.466

100

0.985
  comA Streptococcus mitis SK321

98.326

100

0.983
  comA Streptococcus gordonii str. Challis substr. CH1

80.753

100

0.808
  comA/nlmT Streptococcus mutans UA159

64.714

100

0.647

Multiple sequence alignment