Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   R8566_RS06140 Genome accession   NZ_AP026920
Coordinates   1217562..1218266 (-) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain PZ900700014     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1212562..1223266
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R8566_RS06110 (PC0014_12140) - 1212754..1213740 (+) 987 WP_000204727.1 L-lactate dehydrogenase -
  R8566_RS06115 (PC0014_12150) - 1214000..1214773 (-) 774 WP_000731131.1 potassium channel family protein -
  R8566_RS06120 (PC0014_12160) - 1214820..1215074 (-) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  R8566_RS06125 (PC0014_12170) relB 1215076..1215318 (-) 243 WP_000208080.1 type II toxin-antitoxin system RelB family antitoxin -
  R8566_RS06130 (PC0014_12180) vicX 1215409..1216218 (-) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  R8566_RS06135 (PC0014_12190) micB 1216220..1217569 (-) 1350 WP_000886210.1 cell wall metabolism sensor histidine kinase VicK Regulator
  R8566_RS06140 (PC0014_12200) micA 1217562..1218266 (-) 705 WP_000722076.1 response regulator YycF Regulator
  R8566_RS06145 (PC0014_12210) mutY 1218321..1219496 (-) 1176 WP_000886145.1 A/G-specific adenine glycosylase -
  R8566_RS06150 - 1219593..1219718 (+) 126 WP_001818232.1 hypothetical protein -
  R8566_RS06155 (PC0014_12220) - 1219824..1221494 (-) 1671 WP_000845292.1 formate--tetrahydrofolate ligase -
  R8566_RS06160 (PC0014_12230) coaB 1221724..1222413 (+) 690 WP_000699495.1 phosphopantothenate--cysteine ligase -
  R8566_RS06165 (PC0014_12240) coaC 1222425..1222976 (+) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=97952 R8566_RS06140 WP_000722076.1 1217562..1218266(-) (micA) [Streptococcus pneumoniae strain PZ900700014]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=97952 R8566_RS06140 WP_000722076.1 1217562..1218266(-) (micA) [Streptococcus pneumoniae strain PZ900700014]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTATGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGCACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38

Multiple sequence alignment