Detailed information NTG0097795

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: R8619_RS05630
• Genome accession: NZ_AP026918
• Coordinates: 1109597..1110301 (-)
• Length: 234 a.a.
• NCBI ID: WP_000722076.1
• Uniprot ID: Q9S1K0
• Organism: Streptococcus pneumoniae strain PZ900700009
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1104597..1115301

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R8619_RS05600 (PC0009_11000)	-	1104790..1105776 (+)	987	WP_000204727.1	L-lactate dehydrogenase	-
R8619_RS05605 (PC0009_11010)	-	1106032..1106808 (-)	777	WP_000731138.1	potassium channel family protein	-
R8619_RS05610 (PC0009_11020)	-	1106855..1107109 (-)	255	WP_001809704.1	type II toxin-antitoxin system RelE/ParE family toxin	-
R8619_RS05615 (PC0009_11030)	relB	1107111..1107353 (-)	243	WP_000208080.1	type II toxin-antitoxin system RelB family antitoxin	-
R8619_RS05620 (PC0009_11040)	vicX	1107444..1108253 (-)	810	WP_001289493.1	MBL fold metallo-hydrolase	Regulator
R8619_RS05625 (PC0009_11050)	micB	1108255..1109604 (-)	1350	WP_000886210.1	cell wall metabolism sensor histidine kinase VicK	Regulator
R8619_RS05630 (PC0009_11060)	micA	1109597..1110301 (-)	705	WP_000722076.1	response regulator YycF	Regulator
R8619_RS05635 (PC0009_11070)	mutY	1110356..1111531 (-)	1176	WP_000886145.1	A/G-specific adenine glycosylase	-
R8619_RS05640	-	1111628..1111753 (+)	126	WP_001818232.1	hypothetical protein	-
R8619_RS05645 (PC0009_11080)	-	1111859..1113529 (-)	1671	WP_000845279.1	formate--tetrahydrofolate ligase	-
R8619_RS05650 (PC0009_11090)	coaB	1113759..1114448 (+)	690	WP_000699499.1	phosphopantothenate--cysteine ligase	-
R8619_RS05655 (PC0009_11100)	coaC	1114460..1115011 (+)	552	WP_001284124.1	phosphopantothenoylcysteine decarboxylase	-

Sequence

Protein

• Length: 234 a.a.
• Molecular weight: 26815.63 Da
• Isoelectric Point: 4.7164

>NTDB_id=97795 R8619_RS05630 WP_000722076.1 1109597..1110301(-) (micA) [Streptococcus pneumoniae strain PZ900700009]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide

• Length: 705 bp

>NTDB_id=97795 R8619_RS05630 WP_000722076.1 1109597..1110301(-) (micA) [Streptococcus pneumoniae strain PZ900700009]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGCACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (154-229)

3D structure

• PDB: 1NXS
• PDB: 2A9O
• PDB: 2A9P

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	100	100	1
vicR	Streptococcus mutans UA159	78.541	99.573	0.782
covR	Streptococcus salivarius strain HSISS4	44.156	98.718	0.436
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.478	98.291	0.427
scnR	Streptococcus mutans UA159	38.197	99.573	0.38