Detailed information    

insolico Bioinformatically predicted

Overview

Name   comR   Type   Regulator
Locus tag   ACAM23_RS10400 Genome accession   NZ_AP031394
Coordinates   1973114..1973554 (-) Length   146 a.a.
NCBI ID   WP_050087354.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 16P28     
Function   activate transcription of comX (predicted from homology)   
Competence regulation

Genomic Context

Location: 1968114..1978554
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  ACAM23_RS10370 (SPNE16P28_19960) - 1968423..1969298 (+) 876 WP_000669426.1 substrate-binding domain-containing protein -
  ACAM23_RS10375 (SPNE16P28_19970) pstC 1969416..1970279 (+) 864 WP_000595182.1 phosphate ABC transporter permease subunit PstC -
  ACAM23_RS10380 (SPNE16P28_19980) pstA 1970272..1971087 (+) 816 WP_000049768.1 phosphate ABC transporter permease PstA -
  ACAM23_RS10385 (SPNE16P28_19990) pstB 1971089..1971841 (+) 753 WP_000536449.1 phosphate ABC transporter ATP-binding protein PstB -
  ACAM23_RS10390 (SPNE16P28_20000) phoU 1971856..1972506 (+) 651 WP_050200223.1 phosphate signaling complex protein PhoU -
  ACAM23_RS10395 (SPNE16P28_20010) - 1972568..1972999 (+) 432 Protein_2008 transposase -
  ACAM23_RS10400 (SPNE16P28_20020) comR 1973114..1973554 (-) 441 WP_050087354.1 helix-turn-helix transcriptional regulator Regulator
  ACAM23_RS10405 (SPNE16P28_20030) - 1973766..1974782 (+) 1017 WP_001863200.1 NAD(P)H-dependent glycerol-3-phosphate dehydrogenase -
  ACAM23_RS10410 (SPNE16P28_20040) galU 1974804..1975703 (+) 900 WP_000202235.1 UTP--glucose-1-phosphate uridylyltransferase GalU -
  ACAM23_RS10415 (SPNE16P28_20050) - 1976121..1977053 (+) 933 WP_050200224.1 hypothetical protein -
  ACAM23_RS10420 (SPNE16P28_20060) - 1977156..1977833 (-) 678 WP_000658497.1 rhomboid family intramembrane serine protease -
  ACAM23_RS10425 (SPNE16P28_20070) - 1977817..1978356 (-) 540 WP_000834305.1 5-formyltetrahydrofolate cyclo-ligase -

Sequence

Protein


Download         Length: 146 a.a.        Molecular weight: 17674.37 Da        Isoelectric Point: 4.9895

>NTDB_id=97742 ACAM23_RS10400 WP_050087354.1 1973114..1973554(-) (comR) [Streptococcus pneumoniae strain 16P28]
MREFGEKIKRLRLAKKISRSEFCGDESELSIRQLIRIENGESRPTLTKLKYIAERLGVEDYKLMPSYIELDKEYLELKYF
LMRTPTYEDETIAQKKESVFDKIFEEYYDRLPEEERFIIPNYSYLALTNYTVQKLPEKLVEILSFW

Nucleotide


Download         Length: 441 bp        

>NTDB_id=97742 ACAM23_RS10400 WP_050087354.1 1973114..1973554(-) (comR) [Streptococcus pneumoniae strain 16P28]
TTGCGAGAGTTTGGCGAAAAAATTAAAAGATTACGTTTGGCTAAAAAAATCAGTCGTTCAGAATTTTGTGGTGATGAGTC
TGAATTAAGTATCCGTCAATTAATTAGAATTGAAAATGGAGAATCCAGACCAACACTAACAAAGTTAAAATATATCGCTG
AACGTTTGGGGGTTGAGGATTACAAGTTGATGCCAAGTTATATAGAGTTGGATAAGGAATACCTAGAATTGAAGTATTTC
TTGATGAGGACTCCTACATACGAAGATGAAACTATCGCCCAAAAGAAAGAGAGTGTTTTTGATAAGATTTTTGAAGAGTA
TTATGATAGGCTACCTGAGGAAGAAAGATTTATCATCCCAAATTATTCATATCTGGCACTAACGAACTACACAGTTCAAA
AATTACCAGAAAAGCTAGTTGAAATACTGTCCTTCTGGTGA

Domains

Predicted by InterProScan.

ComR tetratricopeptide (ComR_TPR)

(72-119)

Helix-turn-helix (HTH_3)

(8-59)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comR Streptococcus pyogenes MGAS8232

55

82.192

0.452
  comR Streptococcus pyogenes MGAS315

53.333

82.192

0.438
  comR Streptococcus mutans UA159

53.333

82.192

0.438
  comR Streptococcus infantarius subsp. infantarius ATCC BAA-102

54.545

75.342

0.411
  comR Streptococcus suis P1/7

48.305

80.822

0.39
  comR Streptococcus suis 05ZYH33

48.305

80.822

0.39
  comR Streptococcus suis D9

47.458

80.822

0.384
  comR/comR1 Streptococcus sobrinus strain NIDR 6715-7

47.368

78.082

0.37

Multiple sequence alignment