Detailed information NTG0977040

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: MGAS37859_RS04840
• Genome accession: NZ_CP151442
• Coordinates: 961148..961822 (-)
• Length: 224 a.a.
• NCBI ID: WP_010922355.1
• Uniprot ID: -
• Organism: Streptococcus pyogenes strain MGAS37859
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 956148..966822

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
MGAS37859_RS04815 (MGAS37859_01986)	-	956595..956984 (-)	390	WP_011285547.1	cytidine deaminase	-
MGAS37859_RS04820 (MGAS37859_01988)	-	957643..958230 (-)	588	WP_011285548.1	class I SAM-dependent methyltransferase	-
MGAS37859_RS04825 (MGAS37859_01990)	coaA	958498..959418 (+)	921	WP_010922353.1	type I pantothenate kinase	-
MGAS37859_RS04830 (MGAS37859_01992)	rpsT	959472..959720 (+)	249	WP_009881183.1	30S ribosomal protein S20	-
MGAS37859_RS04835 (MGAS37859_01994)	ciaH	959845..961155 (-)	1311	WP_010922354.1	cell wall metabolism sensor histidine kinase WalK	Regulator
MGAS37859_RS04840 (MGAS37859_01996)	ciaR	961148..961822 (-)	675	WP_010922355.1	response regulator transcription factor	Regulator
MGAS37859_RS04845 (MGAS37859_01998)	-	962168..964705 (-)	2538	WP_010922356.1	M1 family metallopeptidase	-
MGAS37859_RS04850 (MGAS37859_02000)	phoU	964910..965563 (-)	654	WP_027969197.1	phosphate signaling complex protein PhoU	-
MGAS37859_RS04855 (MGAS37859_02002)	pstB	965631..966389 (-)	759	WP_076640023.1	phosphate ABC transporter ATP-binding protein PstB	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25650.86 Da
• Isoelectric Point: 4.6480

>NTDB_id=977040 MGAS37859_RS04840 WP_010922355.1 961148..961822(-) (ciaR) [Streptococcus pyogenes strain MGAS37859]
MIKILLVEDDLSLSNSIFDFLDDFADVMQVFDGDEGLYEAESGIYDLILLDLMLPEKNGFQVLKELREKDIKIPVLIMTA
KEGLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRTGKFADKNISFGNLVVDLARKEVKVEGKVVELLGKEFDLLVY
LLQNQNVILPKTQIFDRLWGFDSDTTISVVEVYISKIRKKLKGTCFVNRLQTLRSVGYILKNNE

Nucleotide

• Length: 675 bp

>NTDB_id=977040 MGAS37859_RS04840 WP_010922355.1 961148..961822(-) (ciaR) [Streptococcus pyogenes strain MGAS37859]
ATGATAAAAATATTATTAGTAGAAGATGACTTGAGCTTATCAAATTCCATTTTTGATTTTTTAGATGATTTTGCAGACGT
CATGCAAGTTTTTGATGGCGATGAAGGTTTATACGAAGCAGAAAGTGGTATTTATGATTTGATTTTGTTAGACCTTATGT
TGCCGGAGAAAAATGGCTTTCAAGTCTTAAAAGAATTGCGAGAAAAAGATATTAAAATTCCTGTATTGATCATGACAGCT
AAAGAGGGTTTAGATGATAAAGGCCACGGATTTGAATTAGGTGCTGATGATTATCTGACAAAGCCGTTCTATTTAGAAGA
GTTAAAAATGCGAATTCAAGCACTGTTAAAAAGAACAGGGAAATTTGCAGATAAAAATATTAGTTTTGGCAATTTAGTGG
TTGACTTAGCTCGAAAAGAGGTGAAGGTTGAAGGGAAAGTAGTTGAATTACTTGGCAAAGAATTTGATTTGTTGGTGTAT
CTTTTGCAAAATCAAAACGTTATTTTACCAAAGACACAAATTTTTGATCGTTTATGGGGATTCGATAGTGATACTACGAT
TTCGGTTGTTGAAGTTTACATTTCTAAAATAAGGAAAAAATTAAAAGGTACCTGTTTTGTTAACAGGCTTCAAACTTTAA
GAAGCGTAGGATATATTCTAAAAAACAATGAATAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

• Response regulator receiver domain (Response_reg) (4-112)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus mutans UA159	85.135	99.107	0.844
ciaR	Streptococcus pneumoniae D39	84.685	99.107	0.839
ciaR	Streptococcus pneumoniae R6	84.685	99.107	0.839
ciaR	Streptococcus pneumoniae TIGR4	84.685	99.107	0.839
ciaR	Streptococcus pneumoniae Rx1	84.685	99.107	0.839
covR	Lactococcus lactis subsp. lactis strain DGCC12653	39.111	100	0.393
vicR	Streptococcus mutans UA159	35.897	100	0.375
micA	Streptococcus pneumoniae Cp1015	35.47	100	0.371
covR	Streptococcus salivarius strain HSISS4	36.283	100	0.366