Detailed information NTG0972962

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: AAAF57_RS04260
• Genome accession: NZ_CP150847
• Coordinates: 953487..954161 (+)
• Length: 224 a.a.
• NCBI ID: WP_002891134.1
• Uniprot ID: J7TS49
• Organism: Streptococcus salivarius strain KSS5
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 948487..959161

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
AAAF57_RS04240 (AAAF57_04285)	-	949602..950174 (-)	573	WP_022496698.1	ECF transporter S component	-
AAAF57_RS04245 (AAAF57_04290)	coaC	950203..950748 (-)	546	WP_022496697.1	phosphopantothenoylcysteine decarboxylase	-
AAAF57_RS04250 (AAAF57_04295)	-	950741..951424 (-)	684	WP_022496696.1	phosphopantothenate--cysteine ligase	-
AAAF57_RS04255 (AAAF57_04300)	-	951619..953289 (+)	1671	WP_004182072.1	formate--tetrahydrofolate ligase	-
AAAF57_RS04260 (AAAF57_04305)	ciaR	953487..954161 (+)	675	WP_002891134.1	response regulator transcription factor	Regulator
AAAF57_RS04265 (AAAF57_04310)	ciaH	954151..955566 (+)	1416	WP_013990466.1	sensor histidine kinase	Regulator
AAAF57_RS04270 (AAAF57_04315)	rpsT	955644..955880 (-)	237	WP_004182129.1	30S ribosomal protein S20	-
AAAF57_RS04275 (AAAF57_04320)	coaA	955950..956870 (-)	921	WP_004182393.1	type I pantothenate kinase	-
AAAF57_RS04280 (AAAF57_04325)	-	956982..957572 (+)	591	WP_410537121.1	class I SAM-dependent methyltransferase	-
AAAF57_RS04285 (AAAF57_04330)	-	957569..958846 (+)	1278	WP_410537122.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.02 Da
• Isoelectric Point: 4.2897

>NTDB_id=972962 AAAF57_RS04260 WP_002891134.1 953487..954161(+) (ciaR) [Streptococcus salivarius strain KSS5]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=972962 AAAF57_RS04260 WP_002891134.1 953487..954161(+) (ciaR) [Streptococcus salivarius strain KSS5]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGTGATGAAGGCCTTTACGAAGCTGAAAGTGGCGTTTATGATTTGATTCTTTTAGACCTTATGT
TGCCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGATGATAAAGGCCACGGCTTTGAACTTGGTGCAGATGACTATCTAACTAAGCCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGATCAAAACACACTTTCTTTTGGAGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAATGTTATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACGGT
ATCAGTTGTTGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: J7TS49

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae D39	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae R6	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae TIGR4	87.444	99.554	0.871
ciaR	Streptococcus mutans UA159	86.607	100	0.866
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362