Detailed information NTG0966172

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: NYE32_RS05790
• Genome accession: NZ_CP150201
• Coordinates: 1201680..1202354 (-)
• Length: 224 a.a.
• NCBI ID: WP_049546057.1
• Uniprot ID: A0A1V0H9R4
• Organism: Streptococcus sp. FSL R7-0248
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1196680..1207354

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NYE32_RS05765 (NYE32_05765)	-	1196987..1198264 (-)	1278	WP_156685123.1	pyrimidine-nucleoside phosphorylase	-
NYE32_RS05770 (NYE32_05770)	-	1198261..1198851 (-)	591	WP_110981457.1	class I SAM-dependent methyltransferase	-
NYE32_RS05775 (NYE32_05775)	coaA	1198964..1199884 (+)	921	WP_037597889.1	type I pantothenate kinase	-
NYE32_RS05780 (NYE32_05780)	rpsT	1199954..1200190 (+)	237	WP_037597891.1	30S ribosomal protein S20	-
NYE32_RS05785 (NYE32_05785)	ciaH	1200275..1201690 (-)	1416	WP_073689923.1	HAMP domain-containing sensor histidine kinase	Regulator
NYE32_RS05790 (NYE32_05790)	ciaR	1201680..1202354 (-)	675	WP_049546057.1	response regulator transcription factor	Regulator
NYE32_RS05795 (NYE32_05795)	-	1202553..1204223 (-)	1671	WP_004182072.1	formate--tetrahydrofolate ligase	-
NYE32_RS05800 (NYE32_05800)	-	1204418..1205101 (+)	684	WP_073689924.1	phosphopantothenate--cysteine ligase	-
NYE32_RS05805 (NYE32_05805)	coaC	1205094..1205639 (+)	546	WP_004182390.1	phosphopantothenoylcysteine decarboxylase	-
NYE32_RS05810 (NYE32_05810)	-	1205668..1206240 (+)	573	WP_004182389.1	ECF transporter S component	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25347.99 Da
• Isoelectric Point: 4.2845

>NTDB_id=966172 NYE32_RS05790 WP_049546057.1 1201680..1202354(-) (ciaR) [Streptococcus sp. FSL R7-0248]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELRDKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=966172 NYE32_RS05790 WP_049546057.1 1201680..1202354(-) (ciaR) [Streptococcus sp. FSL R7-0248]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCCAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
TATGCAGGTCTTTGATGGTGATGAAGGCCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACTTAATGT
TACCTGAAAAAGATGGTTTCACTGTTCTTAGAGAATTACGTGATAAAGGTGTAACAACTCCTGTACTTATCATGACTGCC
AAGGAAAGTCTAGACGATAAGGGACATGGTTTTGAACTTGGTGCGGATGACTATCTAACCAAACCTTTCTACTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTCGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGTGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAT
TTCTTACAAAATCAGAATGTGATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACGGT
ATCAGTTGTTGAAGTATACGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

3D structure

• AlphaFold DB: A0A1V0H9R4

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae D39	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae R6	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae TIGR4	86.996	99.554	0.866
ciaR	Streptococcus mutans UA159	86.161	100	0.862
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362