Detailed information NTG0966099

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: NSQ79_RS04170
• Genome accession: NZ_CP150200
• Coordinates: 959796..960470 (+)
• Length: 224 a.a.
• NCBI ID: WP_002891134.1
• Uniprot ID: J7TS49
• Organism: Streptococcus sp. FSL W7-1342
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 954796..965470

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
NSQ79_RS04145 (NSQ79_04145)	-	955283..955843 (-)	561	WP_013990460.1	ECF transporter S component	-
NSQ79_RS04150 (NSQ79_04150)	-	955910..956482 (-)	573	WP_004182105.1	ECF transporter S component	-
NSQ79_RS04155 (NSQ79_04155)	coaC	956511..957056 (-)	546	WP_073687142.1	phosphopantothenoylcysteine decarboxylase	-
NSQ79_RS04160 (NSQ79_04160)	-	957049..957732 (-)	684	WP_073687143.1	phosphopantothenate--cysteine ligase	-
NSQ79_RS04165 (NSQ79_04165)	-	957927..959597 (+)	1671	WP_073687144.1	formate--tetrahydrofolate ligase	-
NSQ79_RS04170 (NSQ79_04170)	ciaR	959796..960470 (+)	675	WP_002891134.1	response regulator transcription factor	Regulator
NSQ79_RS04175 (NSQ79_04175)	ciaH	960460..961875 (+)	1416	WP_049527921.1	HAMP domain-containing sensor histidine kinase	Regulator
NSQ79_RS04180 (NSQ79_04180)	rpsT	961959..962195 (-)	237	WP_004182129.1	30S ribosomal protein S20	-
NSQ79_RS04185 (NSQ79_04185)	coaA	962265..963185 (-)	921	WP_004182393.1	type I pantothenate kinase	-
NSQ79_RS04190 (NSQ79_04190)	-	963298..963888 (+)	591	WP_004182394.1	class I SAM-dependent methyltransferase	-
NSQ79_RS04195 (NSQ79_04195)	-	963885..965162 (+)	1278	WP_004182395.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.02 Da
• Isoelectric Point: 4.2897

>NTDB_id=966099 NSQ79_RS04170 WP_002891134.1 959796..960470(+) (ciaR) [Streptococcus sp. FSL W7-1342]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=966099 NSQ79_RS04170 WP_002891134.1 959796..960470(+) (ciaR) [Streptococcus sp. FSL W7-1342]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGCCTTTACGAAGCTGAAAGTGGTGTTTATGATTTAATTCTTTTAGACCTTATGT
TGCCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGACGATAAGGGGCACGGCTTTGAACTGGGGGCAGATGACTACCTAACTAAGCCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGATCAGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAGCTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAATGTCATTTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACGGT
ATCAGTTGTTGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: J7TS49

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae D39	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae R6	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae TIGR4	87.444	99.554	0.871
ciaR	Streptococcus mutans UA159	86.607	100	0.866
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362