Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   V6U69_RS04335 Genome accession   NZ_CP145867
Coordinates   965583..966257 (+) Length   224 a.a.
NCBI ID   WP_410534269.1    Uniprot ID   -
Organism   Streptococcus salivarius strain KSS10     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 960583..971257
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  V6U69_RS04315 (V6U69_04315) - 961698..962270 (-) 573 WP_070438309.1 ECF transporter S component -
  V6U69_RS04320 (V6U69_04320) coaC 962299..962844 (-) 546 WP_073686340.1 phosphopantothenoylcysteine decarboxylase -
  V6U69_RS04325 (V6U69_04325) - 962837..963520 (-) 684 WP_110981460.1 phosphopantothenate--cysteine ligase -
  V6U69_RS04330 (V6U69_04330) - 963714..965384 (+) 1671 WP_410534268.1 formate--tetrahydrofolate ligase -
  V6U69_RS04335 (V6U69_04335) ciaR 965583..966257 (+) 675 WP_410534269.1 response regulator transcription factor Regulator
  V6U69_RS04340 (V6U69_04340) ciaH 966247..967662 (+) 1416 WP_410534271.1 sensor histidine kinase Regulator
  V6U69_RS04345 (V6U69_04345) rpsT 967747..967983 (-) 237 WP_037597891.1 30S ribosomal protein S20 -
  V6U69_RS04350 (V6U69_04350) coaA 968053..968973 (-) 921 WP_037597889.1 type I pantothenate kinase -
  V6U69_RS04355 (V6U69_04355) - 969087..969677 (+) 591 WP_073951006.1 class I SAM-dependent methyltransferase -
  V6U69_RS04360 (V6U69_04360) - 969674..970951 (+) 1278 WP_410534273.1 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25404.10 Da        Isoelectric Point: 4.2897

>NTDB_id=940782 V6U69_RS04335 WP_410534269.1 965583..966257(+) (ciaR) [Streptococcus salivarius strain KSS10]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVADKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFVANLQTLRSVGYILKNAD

Nucleotide


Download         Length: 675 bp        

>NTDB_id=940782 V6U69_RS04335 WP_410534269.1 965583..966257(+) (ciaR) [Streptococcus salivarius strain KSS10]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCCAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
TATGCAGGTCTTTGATGGTGATGAAGGCCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT
TGCCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGCGAAAAAGGTGTAACGACTCCTGTTCTTATCATGACGGCA
AAGGAAAGTCTAGACGATAAGGGACACGGCTTTGAACTGGGGGCAGATGACTATCTAACCAAACCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAGGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTCGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGCTGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAGAATGTGATCTTGCCTAAGTCACAAATTTTTGATCGTCTTTGGGGATTTGATAGTGATACCACGGT
ATCAGTTGTTGAAGTATACGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGTTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

86.996

99.554

0.866
  ciaR Streptococcus pneumoniae D39

86.996

99.554

0.866
  ciaR Streptococcus pneumoniae R6

86.996

99.554

0.866
  ciaR Streptococcus pneumoniae TIGR4

86.996

99.554

0.866
  ciaR Streptococcus mutans UA159

86.607

100

0.866
  vicR Streptococcus mutans UA159

36.402

100

0.388
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.326

100

0.388
  micA Streptococcus pneumoniae Cp1015

34.746

100

0.366