NTDB

Overview

Name	ciaR	Type	Regulator
Locus tag	V6U68_RS05875	Genome accession	NZ_CP145866
Coordinates	1207778..1208452 (-)	Length	224 a.a.
NCBI ID	WP_049546057.1	Uniprot ID	A0A1V0H9R4
Organism	Streptococcus salivarius strain KSS9
Function	repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1202778..1213452

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
V6U68_RS05850 (V6U68_05840)	-	1203085..1204362 (-)	1278	WP_013990469.1	pyrimidine-nucleoside phosphorylase	-
V6U68_RS05855 (V6U68_05845)	-	1204359..1204949 (-)	591	WP_013990468.1	class I SAM-dependent methyltransferase	-
V6U68_RS05860 (V6U68_05850)	coaA	1205062..1205982 (+)	921	WP_013990467.1	type I pantothenate kinase	-
V6U68_RS05865 (V6U68_05855)	rpsT	1206052..1206288 (+)	237	WP_004182129.1	30S ribosomal protein S20	-
V6U68_RS05870 (V6U68_05860)	ciaH	1206373..1207788 (-)	1416	WP_410531379.1	sensor histidine kinase	Regulator
V6U68_RS05875 (V6U68_05865)	ciaR	1207778..1208452 (-)	675	WP_049546057.1	response regulator transcription factor	Regulator
V6U68_RS05880 (V6U68_05870)	-	1208651..1210321 (-)	1671	WP_013990464.1	formate--tetrahydrofolate ligase	-
V6U68_RS05885 (V6U68_05875)	-	1210516..1211199 (+)	684	WP_013990463.1	phosphopantothenate--cysteine ligase	-
V6U68_RS05890 (V6U68_05880)	coaC	1211192..1211737 (+)	546	WP_013990462.1	phosphopantothenoylcysteine decarboxylase	-
V6U68_RS05895 (V6U68_05885)	-	1211766..1212338 (+)	573	WP_022496698.1	ECF transporter S component	-

Sequence

Protein

Download Length: 224 a.a. Molecular weight: 25347.99 Da Isoelectric Point: 4.2845

                                >NTDB_id=940721 V6U68_RS05875 WP_049546057.1 1207778..1208452(-) (ciaR) [Streptococcus salivarius strain KSS9]

MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELRDKGVTTPVLIMTA

KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY

FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

Download Length: 675 bp

                                >NTDB_id=940721 V6U68_RS05875 WP_049546057.1 1207778..1208452(-) (ciaR) [Streptococcus salivarius strain KSS9]

ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCCAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT

TATGCAGGTCTTTGATGGTGATGAAGGCCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACTTAATGT

TACCTGAAAAAGATGGTTTCACTGTTCTTAGAGAATTACGTGATAAAGGTGTAACAACTCCTGTACTTATCATGACTGCC

AAGGAAAGTCTAGACGATAAGGGACATGGTTTTGAACTTGGTGCGGATGACTATCTAACCAAACCTTTCTACTTAGAAGA

GTTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAACACACTTTCTTTCGGTGATGTTCGTG

TCAATCTTGCTACAAATTCAACCTTTGTGGGTGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAT

TTCTTACAAAATCAGAATGTGATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACGGT

ATCAGTTGTTGAAGTATACGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA

GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure
AlphaFold DB	A0A1V0H9R4

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaR	Streptococcus pneumoniae Rx1	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae D39	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae R6	86.996	99.554	0.866
ciaR	Streptococcus pneumoniae TIGR4	86.996	99.554	0.866
ciaR	Streptococcus mutans UA159	86.161	100	0.862
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362

Detailed information NTG0940721