Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   V6U67_RS05850 Genome accession   NZ_CP145865
Coordinates   1210390..1211064 (-) Length   224 a.a.
NCBI ID   WP_214256703.1    Uniprot ID   -
Organism   Streptococcus salivarius strain KSS8     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 1205390..1216064
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  V6U67_RS05825 (V6U67_05835) - 1205650..1206779 (-) 1130 Protein_1104 IS3 family transposase -
  V6U67_RS05830 (V6U67_05840) - 1206873..1207671 (-) 799 Protein_1105 alpha/beta fold hydrolase -
  V6U67_RS05835 (V6U67_05845) - 1207702..1208145 (-) 444 WP_272125733.1 GNAT family N-acetyltransferase -
  V6U67_RS05840 (V6U67_05850) - 1208155..1208998 (-) 844 Protein_1107 DUF2130 domain-containing protein -
  V6U67_RS05845 (V6U67_05855) ciaH 1208985..1210400 (-) 1416 WP_272125732.1 sensor histidine kinase Regulator
  V6U67_RS05850 (V6U67_05860) ciaR 1210390..1211064 (-) 675 WP_214256703.1 response regulator transcription factor Regulator
  V6U67_RS05855 (V6U67_05865) - 1211262..1212932 (-) 1671 WP_004182072.1 formate--tetrahydrofolate ligase -
  V6U67_RS05860 (V6U67_05870) - 1213127..1213810 (+) 684 WP_022496696.1 phosphopantothenate--cysteine ligase -
  V6U67_RS05865 (V6U67_05875) coaC 1213803..1214348 (+) 546 WP_272125731.1 phosphopantothenoylcysteine decarboxylase -
  V6U67_RS05870 (V6U67_05880) - 1214377..1214949 (+) 573 WP_084914458.1 ECF transporter S component -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25392.04 Da        Isoelectric Point: 4.2897

>NTDB_id=940651 V6U67_RS05850 WP_214256703.1 1210390..1211064(-) (ciaR) [Streptococcus salivarius strain KSS8]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFTANLQTLRSVGYILKNAD

Nucleotide


Download         Length: 675 bp        

>NTDB_id=940651 V6U67_RS05850 WP_214256703.1 1210390..1211064(-) (ciaR) [Streptococcus salivarius strain KSS8]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT
TACCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACTCCTGTACTTATCATGACTGCT
AAGGAAAGTCTAGATGATAAGGGTCATGGCTTTGAACTGGGTGCAGACGACTATCTAACCAAACCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGATCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAATGTCATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACGGT
ATCAGTTGTCGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTACTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

86.996

99.554

0.866
  ciaR Streptococcus pneumoniae D39

86.996

99.554

0.866
  ciaR Streptococcus pneumoniae R6

86.996

99.554

0.866
  ciaR Streptococcus pneumoniae TIGR4

86.996

99.554

0.866
  ciaR Streptococcus mutans UA159

86.607

100

0.866
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.222

100

0.384
  vicR Streptococcus mutans UA159

35.983

100

0.384
  micA Streptococcus pneumoniae Cp1015

34.322

100

0.362