NTDB

Overview

Name	ciaH	Type	Regulator
Locus tag	V6U67_RS05845	Genome accession	NZ_CP145865
Coordinates	1208985..1210400 (-)	Length	471 a.a.
NCBI ID	WP_272125732.1	Uniprot ID	-
Organism	Streptococcus salivarius strain KSS8
Function	Required for optimal comC expression (predicted from homology) Competence regulation

Genomic Context

Location: 1203985..1215400

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
V6U67_RS05815 (V6U67_05825)	coaA	1204331..1205251 (+)	921	WP_038676170.1	type I pantothenate kinase	-
V6U67_RS05820 (V6U67_05830)	rpsT	1205321..1205557 (+)	237	WP_004182129.1	30S ribosomal protein S20	-
V6U67_RS05825 (V6U67_05835)	-	1205650..1206779 (-)	1130	Protein_1104	IS3 family transposase	-
V6U67_RS05830 (V6U67_05840)	-	1206873..1207671 (-)	799	Protein_1105	alpha/beta fold hydrolase	-
V6U67_RS05835 (V6U67_05845)	-	1207702..1208145 (-)	444	WP_272125733.1	GNAT family N-acetyltransferase	-
V6U67_RS05840 (V6U67_05850)	-	1208155..1208998 (-)	844	Protein_1107	DUF2130 domain-containing protein	-
V6U67_RS05845 (V6U67_05855)	ciaH	1208985..1210400 (-)	1416	WP_272125732.1	sensor histidine kinase	Regulator
V6U67_RS05850 (V6U67_05860)	ciaR	1210390..1211064 (-)	675	WP_214256703.1	response regulator transcription factor	Regulator
V6U67_RS05855 (V6U67_05865)	-	1211262..1212932 (-)	1671	WP_004182072.1	formate--tetrahydrofolate ligase	-
V6U67_RS05860 (V6U67_05870)	-	1213127..1213810 (+)	684	WP_022496696.1	phosphopantothenate--cysteine ligase	-
V6U67_RS05865 (V6U67_05875)	coaC	1213803..1214348 (+)	546	WP_272125731.1	phosphopantothenoylcysteine decarboxylase	-
V6U67_RS05870 (V6U67_05880)	-	1214377..1214949 (+)	573	WP_084914458.1	ECF transporter S component	-

Sequence

Protein

Download Length: 471 a.a. Molecular weight: 53522.26 Da Isoelectric Point: 8.1737

                                >NTDB_id=940650 V6U67_RS05845 WP_272125732.1 1208985..1210400(-) (ciaH) [Streptococcus salivarius strain KSS8]

MLTKFFNYLFRRIKSDGFKSFIHFFATFSGIFLIMTVMILQILSYGVYSNVDSSLKMAATKTNSYLEMEMLKRELFLTSE

VDQNNTTTIYQAYDTKESTTETSDSSDSKKEPKKKSKIEDAPHDLSVAANTSVLVLDKNGKVLNVVDKFSSLSNLPIDKN

NIDVISKGSAQNYFDQTEKYRLITEKVDNSLYPDAKYLVIAINTTQLEEATERYVKLIVIMMSFFWLLSVAASMYLAKWS

RRPIQESLEKQKAFVENASHELRTPLAVIQNRLEVLFRKPESTILDNSENIASSLDEVRNMRLLTTNLLNLARRDDGIKP

EIETLEPAFFDTVFTNYAMIAEENEKGFTAQNQVGRPIQTDKTLLKQLMTILFDNAIKYTEDDGHVTFTVRTNDRHLYIS

VADNGPGISDSDKKKIFDRFYRVDKARTRQKGGFGLGLSLAQQIVLALKGAIVVKDNQPKGTIFEVKITGV

Nucleotide

Download Length: 1416 bp

                                >NTDB_id=940650 V6U67_RS05845 WP_272125732.1 1208985..1210400(-) (ciaH) [Streptococcus salivarius strain KSS8]

ATGCTGACTAAATTTTTCAATTATCTCTTTAGGAGAATCAAGTCAGACGGATTTAAGTCGTTCATTCATTTCTTTGCTAC

TTTTTCTGGTATTTTCCTTATCATGACTGTCATGATTTTACAGATTCTGAGTTATGGCGTTTATTCCAATGTGGACTCTA

GTCTGAAAATGGCAGCAACTAAGACCAATTCTTATTTAGAAATGGAAATGCTCAAACGGGAACTTTTTCTGACTTCTGAG

GTAGATCAAAATAATACAACAACCATTTACCAAGCCTATGATACTAAAGAGTCGACAACTGAAACATCTGACTCGAGTGA

CTCTAAAAAAGAACCTAAGAAGAAATCAAAGATAGAAGATGCTCCTCACGATTTATCAGTTGCTGCAAATACCAGTGTCT

TGGTACTTGATAAGAATGGAAAAGTCCTTAATGTCGTTGATAAATTTTCAAGCTTATCCAATTTACCAATAGATAAAAAT

AACATTGATGTTATCAGCAAGGGAAGTGCTCAGAATTATTTCGATCAAACGGAAAAGTATCGCTTGATCACTGAGAAAGT

AGACAATAGTCTCTATCCTGATGCTAAGTACCTTGTTATTGCGATTAATACAACTCAATTGGAAGAAGCTACTGAACGTT

ATGTTAAGCTAATTGTCATCATGATGAGTTTCTTCTGGCTCTTATCAGTTGCGGCTAGTATGTATTTGGCTAAGTGGTCA

AGGCGTCCTATCCAGGAAAGTTTGGAGAAGCAGAAGGCTTTTGTTGAGAATGCTAGTCATGAGTTACGGACACCGCTTGC

TGTGATTCAAAACAGGTTAGAAGTTCTTTTCCGCAAGCCTGAGAGTACTATTTTAGATAATTCAGAGAATATTGCTTCAA

GTCTTGATGAAGTACGTAACATGCGTCTTTTGACGACTAATCTCTTGAACTTGGCTCGTCGTGACGATGGTATTAAACCA

GAAATCGAAACCTTAGAACCTGCTTTCTTTGATACAGTATTTACCAACTATGCCATGATTGCAGAAGAAAATGAGAAAGG

TTTCACGGCTCAAAACCAAGTTGGTCGTCCAATCCAGACTGATAAAACGTTATTGAAACAGTTAATGACCATCTTATTTG

ATAATGCTATTAAATATACGGAAGATGACGGACATGTTACCTTTACTGTCCGCACTAATGATCGCCATCTTTATATTTCT

GTAGCTGATAATGGTCCTGGAATATCAGATAGTGATAAGAAAAAAATCTTTGATCGATTTTATCGCGTAGATAAGGCTAG

AACCAGACAAAAAGGTGGGTTTGGACTTGGCTTATCCCTAGCGCAACAAATTGTTTTAGCCCTAAAAGGAGCAATTGTTG

TAAAAGATAATCAACCAAAGGGAACGATTTTTGAAGTTAAGATTACTGGAGTCTAA

Domains

Predicted by InterproScan.

His Kinase A (phospho-acceptor) domain (HisKA)

(252-317)

Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c)

(361-468)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
ciaH	Streptococcus mutans UA159	56.522	97.665	0.552
ciaH	Streptococcus pneumoniae Rx1	50	98.514	0.493
ciaH	Streptococcus pneumoniae D39	50	98.514	0.493
ciaH	Streptococcus pneumoniae R6	50	98.514	0.493
ciaH	Streptococcus pneumoniae TIGR4	50	98.514	0.493

Detailed information NTG0940650