Detailed information NTG0940579

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: V6U66_RS04575
• Genome accession: NZ_CP145864
• Coordinates: 1023003..1023677 (+)
• Length: 224 a.a.
• NCBI ID: WP_004182019.1
• Uniprot ID: A0AAW6D9L9
• Organism: Streptococcus salivarius strain KSS7
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1018003..1028677

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
V6U66_RS04550 (V6U66_04535)	-	1018491..1019051 (-)	561	WP_004182060.1	ECF transporter S component	-
V6U66_RS04555 (V6U66_04540)	-	1019118..1019690 (-)	573	WP_084871334.1	ECF transporter S component	-
V6U66_RS04560 (V6U66_04545)	coaC	1019719..1020264 (-)	546	WP_084871335.1	phosphopantothenoylcysteine decarboxylase	-
V6U66_RS04565 (V6U66_04550)	-	1020257..1020940 (-)	684	WP_084871336.1	phosphopantothenate--cysteine ligase	-
V6U66_RS04570 (V6U66_04555)	-	1021134..1022804 (+)	1671	WP_048675542.1	formate--tetrahydrofolate ligase	-
V6U66_RS04575 (V6U66_04560)	ciaR	1023003..1023677 (+)	675	WP_004182019.1	response regulator transcription factor	Regulator
V6U66_RS04580 (V6U66_04565)	ciaH	1023667..1025082 (+)	1416	WP_037604990.1	sensor histidine kinase	Regulator
V6U66_RS04585 (V6U66_04570)	rpsT	1025166..1025402 (-)	237	WP_004182129.1	30S ribosomal protein S20	-
V6U66_RS04590 (V6U66_04575)	coaA	1025472..1026392 (-)	921	WP_004182102.1	type I pantothenate kinase	-
V6U66_RS04595 (V6U66_04580)	-	1026505..1027095 (+)	591	WP_155213883.1	class I SAM-dependent methyltransferase	-
V6U66_RS04600 (V6U66_04585)	-	1027092..1028369 (+)	1278	WP_155213884.1	pyrimidine-nucleoside phosphorylase	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25392.04 Da
• Isoelectric Point: 4.2897

>NTDB_id=940579 V6U66_RS04575 WP_004182019.1 1023003..1023677(+) (ciaR) [Streptococcus salivarius strain KSS7]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFATNLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=940579 V6U66_RS04575 WP_004182019.1 1023003..1023677(+) (ciaR) [Streptococcus salivarius strain KSS7]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACTTAATGT
TGCCTGAAAAAGATGGTTTCACTGTTCTTAGAGAATTACGTGAAAAGGGTGTAACAACCCCTGTACTAATCATGACGGCT
AAGGAAAGTCTAGACGATAAGGGACACGGCTTTGAACTGGGTGCAGATGACTACCTAACTAAGCCTTTCTATTTAGAAGA
ATTGAAGATGCGTATTCAAGCACTTTTGAAACGCTCTGGTAAATTTGACCAAAATACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAATGTCATCTTGCCTAAGTCACAAATTTTTGATCGTCTTTGGGGATTTGATAGTGATACCACAGT
ATCAGTTGTAGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTACCAATCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Response regulator receiver domain (Response_reg) (4-112)

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae D39	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae R6	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae TIGR4	87.444	99.554	0.871
ciaR	Streptococcus mutans UA159	86.607	100	0.866
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362