Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   V6U62_RS04360 Genome accession   NZ_CP145860
Coordinates   971702..972376 (+) Length   224 a.a.
NCBI ID   WP_002891134.1    Uniprot ID   J7TS49
Organism   Streptococcus salivarius strain KSS2     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 966702..977376
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  V6U62_RS04340 (V6U62_04330) - 967816..968388 (-) 573 WP_022496698.1 ECF transporter S component -
  V6U62_RS04345 (V6U62_04335) coaC 968417..968962 (-) 546 WP_022496697.1 phosphopantothenoylcysteine decarboxylase -
  V6U62_RS04350 (V6U62_04340) - 968955..969638 (-) 684 WP_022496696.1 phosphopantothenate--cysteine ligase -
  V6U62_RS04355 (V6U62_04345) - 969833..971503 (+) 1671 WP_004182072.1 formate--tetrahydrofolate ligase -
  V6U62_RS04360 (V6U62_04350) ciaR 971702..972376 (+) 675 WP_002891134.1 response regulator transcription factor Regulator
  V6U62_RS04365 (V6U62_04355) ciaH 972366..973781 (+) 1416 WP_037600837.1 sensor histidine kinase Regulator
  V6U62_RS04370 (V6U62_04360) rpsT 973859..974095 (-) 237 WP_004182129.1 30S ribosomal protein S20 -
  V6U62_RS04375 (V6U62_04365) coaA 974165..975085 (-) 921 WP_022496694.1 type I pantothenate kinase -
  V6U62_RS04380 (V6U62_04370) - 975198..975788 (+) 591 WP_014633038.1 class I SAM-dependent methyltransferase -
  V6U62_RS04385 (V6U62_04375) - 975785..977062 (+) 1278 WP_022496693.1 pyrimidine-nucleoside phosphorylase -

Sequence

Protein


Download         Length: 224 a.a.        Molecular weight: 25362.02 Da        Isoelectric Point: 4.2897

>NTDB_id=940311 V6U62_RS04360 WP_002891134.1 971702..972376(+) (ciaR) [Streptococcus salivarius strain KSS2]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide


Download         Length: 675 bp        

>NTDB_id=940311 V6U62_RS04360 WP_002891134.1 971702..972376(+) (ciaR) [Streptococcus salivarius strain KSS2]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT
TACCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACCCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGATGATAAGGGTCATGGCTTTGAACTGGGTGCAGACGACTATCTAACCAAACCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGATCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAATGTCATCTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACGGT
ATCAGTTGTCGAGGTTTATGTTTCTAAAATTCGTAAGAAACTAAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTATATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-220)

Response regulator receiver domain (Response_reg)

(4-112)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB J7TS49

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae D39

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae R6

87.444

99.554

0.871
  ciaR Streptococcus pneumoniae TIGR4

87.444

99.554

0.871
  ciaR Streptococcus mutans UA159

86.607

100

0.866
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.222

100

0.384
  vicR Streptococcus mutans UA159

35.983

100

0.384
  micA Streptococcus pneumoniae Cp1015

34.322

100

0.362