Detailed information NTG0940185

Bioinformatically predicted

Overview

• Name: ciaR
• Type: Regulator
• Locus tag: V6T01_RS05955
• Genome accession: NZ_CP145856
• Coordinates: 1223557..1224231 (-)
• Length: 224 a.a.
• NCBI ID: WP_002891134.1
• Uniprot ID: J7TS49
• Organism: Streptococcus salivarius strain KSS1
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 1218557..1229231

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
V6T01_RS05930 (V6T01_05915)	-	1218864..1220141 (-)	1278	WP_073689921.1	pyrimidine-nucleoside phosphorylase	-
V6T01_RS05935 (V6T01_05920)	-	1220138..1220728 (-)	591	WP_073689922.1	class I SAM-dependent methyltransferase	-
V6T01_RS05940 (V6T01_05925)	coaA	1220841..1221761 (+)	921	WP_013990467.1	type I pantothenate kinase	-
V6T01_RS05945 (V6T01_05930)	rpsT	1221831..1222067 (+)	237	WP_004182129.1	30S ribosomal protein S20	-
V6T01_RS05950 (V6T01_05935)	ciaH	1222152..1223567 (-)	1416	WP_410541498.1	sensor histidine kinase	Regulator
V6T01_RS05955 (V6T01_05940)	ciaR	1223557..1224231 (-)	675	WP_002891134.1	response regulator transcription factor	Regulator
V6T01_RS05960 (V6T01_05945)	-	1224429..1226099 (-)	1671	WP_247924893.1	formate--tetrahydrofolate ligase	-
V6T01_RS05965 (V6T01_05950)	-	1226293..1226976 (+)	684	WP_410541497.1	phosphopantothenate--cysteine ligase	-
V6T01_RS05970 (V6T01_05955)	coaC	1226969..1227514 (+)	546	WP_410541496.1	phosphopantothenoylcysteine decarboxylase	-
V6T01_RS05975 (V6T01_05960)	-	1227543..1228115 (+)	573	WP_004182389.1	ECF transporter S component	-

Sequence

Protein

• Length: 224 a.a.
• Molecular weight: 25362.02 Da
• Isoelectric Point: 4.2897

>NTDB_id=940185 V6T01_RS05955 WP_002891134.1 1223557..1224231(-) (ciaR) [Streptococcus salivarius strain KSS1]
MIKILLVEDDLSLSNSVFDFLDDFADVMQVFDGDEGLYEAESGVYDLILLDLMLPEKDGFTVLRELREKGVTTPVLIMTA
KESLDDKGHGFELGADDYLTKPFYLEELKMRIQALLKRSGKFDQNTLSFGDVRVNLATNSTFVGDKEVELLGKEFDLLVY
FLQNQNVILPKSQIFDRLWGFDSDTTVSVVEVYVSKIRKKLKGTDFAANLQTLRSVGYILKNAD

Nucleotide

• Length: 675 bp

>NTDB_id=940185 V6T01_RS05955 WP_002891134.1 1223557..1224231(-) (ciaR) [Streptococcus salivarius strain KSS1]
ATGATTAAAATACTACTAGTAGAAGATGATTTGAGTTTGTCGAACTCAGTTTTTGATTTTTTAGATGACTTTGCTGATGT
GATGCAAGTCTTTGATGGAGATGAAGGTCTCTACGAAGCTGAAAGTGGCGTCTATGATTTGATTCTTTTAGACCTTATGT
TACCTGAAAAAGATGGTTTCACGGTTCTTAGAGAATTACGTGAAAAAGGTGTAACAACTCCTGTACTTATCATGACGGCT
AAGGAAAGTCTAGATGATAAGGGTCATGGCTTTGAACTGGGTGCAGACGACTATCTAACCAAACCTTTCTATTTAGAAGA
GTTGAAGATGCGTATTCAAGCACTTTTGAAACGATCTGGTAAATTTGACCAAAACACACTTTCTTTTGGTGATGTTCGTG
TCAATCTTGCTACAAATTCAACCTTTGTGGGGGATAAAGAAGTAGAACTTCTTGGTAAAGAGTTTGATTTATTAGTTTAC
TTCTTACAAAATCAAAACGTAATTTTGCCTAAGTCACAAATTTTTGACCGTCTTTGGGGATTTGATAGTGATACCACAGT
ATCAGTTGTTGAGGTTTATGTTTCTAAAATTCGTAAGAAACTTAAAGGAACAGACTTTGCTGCCAACCTCCAAACCTTGA
GAAGTGTGGGGTACATTTTGAAGAATGCTGACTAA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (146-220)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: J7TS49

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaR	Streptococcus pneumoniae Rx1	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae D39	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae R6	87.444	99.554	0.871
ciaR	Streptococcus pneumoniae TIGR4	87.444	99.554	0.871
ciaR	Streptococcus mutans UA159	86.607	100	0.866
covR	Lactococcus lactis subsp. lactis strain DGCC12653	38.222	100	0.384
vicR	Streptococcus mutans UA159	35.983	100	0.384
micA	Streptococcus pneumoniae Cp1015	34.322	100	0.362