NTDB

Overview

Name	covR	Type	Regulator
Locus tag	VVB72_RS08275	Genome accession	NZ_CP142589
Coordinates	1667121..1667813 (-)	Length	230 a.a.
NCBI ID	WP_012898209.1	Uniprot ID	A0AAW7IPJ0
Organism	Lactococcus lactis subsp. lactis strain C20
Function	repress the expression of comX (predicted from homology) Competence regulation

Genomic Context

Location: 1662121..1672813

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
VVB72_RS08260 (VVB72_08260)	-	1663740..1664081 (-)	342	WP_010906046.1	P-II family nitrogen regulator	-
VVB72_RS08265 (VVB72_08265)	-	1664213..1665454 (-)	1242	WP_039115695.1	ammonium transporter	-
VVB72_RS08270 (VVB72_08270)	covS	1665637..1667112 (-)	1476	WP_010906048.1	HAMP domain-containing histidine kinase	Regulator
VVB72_RS08275 (VVB72_08275)	covR	1667121..1667813 (-)	693	WP_012898209.1	response regulator transcription factor	Regulator
VVB72_RS08280 (VVB72_08280)	-	1667969..1668499 (-)	531	WP_012898210.1	YceD family protein	-
VVB72_RS08285 (VVB72_08285)	-	1668630..1668875 (-)	246	WP_003130760.1	type B 50S ribosomal protein L31	-
VVB72_RS08290 (VVB72_08290)	-	1669031..1669495 (-)	465	WP_023188701.1	hypothetical protein	-
VVB72_RS08295 (VVB72_08295)	-	1669577..1669939 (-)	363	WP_023188700.1	TIGR02328 family protein	-
VVB72_RS08300 (VVB72_08300)	-	1670165..1671076 (-)	912	WP_023188699.1	CHAP domain-containing protein	-
VVB72_RS08305 (VVB72_08305)	-	1671189..1672025 (-)	837	WP_039115700.1	metallophosphoesterase	-

Sequence

Protein

Download Length: 230 a.a. Molecular weight: 26670.33 Da Isoelectric Point: 5.1273

                                >NTDB_id=926076 VVB72_RS08275 WP_012898209.1 1667121..1667813(-) (covR) [Lactococcus lactis subsp. lactis strain C20]

MTSKKILIIEDEKNLARFVSLELEHEGYATEIKDNGRSGLEEASSKDYDLILLDLMLPELDGFEVARRLRKEKDTPIIMM

TARDSTMDRVAGLDIGADDYITKPFAIEELLARVRAFFRREEHGHAVERAENTSFRDLVIDKTNRTVHRGKKVIDLTRRE

YDLLLTLMQNVGDVVTREHLVSQVWGYEEGTETNVVDVYIRYLRNKIDVEGQDSYIQTVRGLGYVMRERK

Nucleotide

Download Length: 693 bp

                                >NTDB_id=926076 VVB72_RS08275 WP_012898209.1 1667121..1667813(-) (covR) [Lactococcus lactis subsp. lactis strain C20]

ATGACTTCAAAGAAAATTTTGATTATTGAGGATGAAAAGAATTTAGCGCGATTCGTCTCATTAGAATTAGAACATGAAGG

CTATGCGACTGAGATTAAAGATAATGGTCGTTCTGGTCTTGAAGAAGCAAGTTCAAAAGATTATGATTTAATCTTGCTTG

ATTTGATGCTTCCTGAACTTGACGGTTTTGAGGTAGCTCGTCGTTTACGAAAAGAAAAAGATACACCAATCATTATGATG

ACGGCACGTGATTCAACGATGGACCGTGTTGCTGGTCTTGATATTGGGGCTGATGATTATATCACTAAACCTTTTGCGAT

TGAGGAACTTTTGGCGCGTGTTCGTGCTTTCTTCCGTCGTGAAGAGCATGGTCATGCCGTTGAACGTGCTGAAAATACTT

CTTTCCGTGATCTTGTGATTGACAAAACGAATCGCACCGTTCATCGTGGTAAAAAAGTAATTGATTTAACACGTCGTGAG

TATGACCTCCTTTTGACATTGATGCAAAATGTTGGCGATGTTGTGACTCGTGAACATTTAGTTTCACAAGTTTGGGGATA

TGAAGAAGGAACAGAAACAAATGTTGTGGATGTTTATATTCGTTATCTTAGAAATAAAATTGATGTTGAAGGTCAAGATA

GCTATATTCAAACTGTTCGTGGCTTAGGTTATGTAATGCGTGAACGCAAATAA

Domains

Predicted by InterproScan.

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(153-226)

Response regulator receiver domain (Response_reg)

(6-115)

Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.

3D structure

Source	ID	Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.

Visualization of predicted probability:

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	H_a-value
covR	Lactococcus lactis subsp. lactis strain DGCC12653	99.565	100	0.996
covR	Streptococcus salivarius strain HSISS4	68.421	99.13	0.678
vicR	Streptococcus mutans UA159	45.887	100	0.461
micA	Streptococcus pneumoniae Cp1015	43.478	100	0.435
ciaR	Streptococcus mutans UA159	37.611	98.261	0.37
ciaR	Streptococcus pneumoniae Rx1	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae D39	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae R6	36.726	98.261	0.361
ciaR	Streptococcus pneumoniae TIGR4	36.726	98.261	0.361

Detailed information NTG0926076