Detailed information    

insolico Bioinformatically predicted

Overview

Name   vicR   Type   Regulator
Locus tag   VKP53_RS06750 Genome accession   NZ_CP142354
Coordinates   1367161..1367871 (-) Length   236 a.a.
NCBI ID   WP_002985645.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain 6745-99     
Function   repress comCDE expression; repress comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1362161..1372871
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  VKP53_RS06735 (VKP53_06735) rnc 1363878..1364570 (-) 693 WP_002990670.1 ribonuclease III -
  VKP53_RS06740 (VKP53_06740) vicX 1365003..1365812 (-) 810 WP_023612763.1 MBL fold metallo-hydrolase Regulator
  VKP53_RS06745 (VKP53_06745) vicK 1365816..1367168 (-) 1353 WP_326674734.1 cell wall metabolism sensor histidine kinase VicK Regulator
  VKP53_RS06750 (VKP53_06750) vicR 1367161..1367871 (-) 711 WP_002985645.1 response regulator YycF Regulator
  VKP53_RS06755 (VKP53_06755) - 1368033..1369067 (-) 1035 WP_011284595.1 DUF3114 domain-containing protein -
  VKP53_RS06760 (VKP53_06760) - 1369123..1370370 (-) 1248 WP_047235203.1 AMP-binding protein -
  VKP53_RS06765 (VKP53_06765) - 1370327..1371475 (-) 1149 WP_031488431.1 acetyl-CoA C-acyltransferase -
  VKP53_RS06770 (VKP53_06770) - 1371444..1372013 (-) 570 Protein_1282 hypothetical protein -
  VKP53_RS06775 (VKP53_06775) - 1372148..1372861 (-) 714 WP_301182272.1 MIP/aquaporin family protein -

Sequence

Protein


Download         Length: 236 a.a.        Molecular weight: 27083.99 Da        Isoelectric Point: 4.9038

>NTDB_id=925228 VKP53_RS06750 WP_002985645.1 1367161..1367871(-) (vicR) [Streptococcus pyogenes strain 6745-99]
MKKILIVDDEKPISDIIKFNLTKEGYDIVTAFDGREAVTIFEEEKPDLIILDLMLPELDGLEVAKEIRKTSHVPIIMLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELLARVKAHLRRTETIETAVAEENASSGTQELTIGNLQILPDAFVAKKHGQEVE
LTHREFELLHHLANHMGQVMTREHLLEIVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMKSYD

Nucleotide


Download         Length: 711 bp        

>NTDB_id=925228 VKP53_RS06750 WP_002985645.1 1367161..1367871(-) (vicR) [Streptococcus pyogenes strain 6745-99]
ATGAAAAAAATACTTATTGTGGATGATGAAAAACCGATTTCTGACATTATTAAGTTTAATTTGACAAAAGAAGGTTATGA
CATTGTTACAGCTTTTGATGGACGCGAAGCGGTAACAATTTTTGAAGAAGAAAAGCCAGATTTAATTATTCTTGATTTGA
TGCTCCCTGAGTTGGACGGTCTTGAAGTAGCCAAGGAAATTCGTAAAACCAGTCATGTCCCGATTATTATGTTGTCGGCT
AAAGATAGTGAGTTTGACAAGGTTATTGGACTTGAAATTGGGGCTGATGATTACGTGACCAAGCCCTTTTCTAATCGGGA
ATTGCTGGCACGTGTCAAGGCTCATCTGCGTCGTACCGAAACTATTGAAACGGCTGTTGCAGAAGAAAATGCTTCTTCAG
GTACACAGGAACTAACCATTGGTAATTTACAGATTTTACCAGATGCGTTTGTTGCTAAAAAACATGGTCAAGAGGTAGAG
TTGACCCATCGTGAATTTGAACTATTGCATCATCTAGCTAACCATATGGGTCAGGTGATGACACGAGAACACTTATTGGA
AATTGTTTGGGGATATGATTATTTTGGCGATGTGCGCACGGTTGATGTGACTGTTCGTCGTCTCCGTGAAAAAATTGAAG
ACACACCAAGTCGTCCTGAGTATATTTTAACAAGACGTGGTGTTGGGTACTACATGAAATCTTATGACTAG

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(156-231)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  vicR Streptococcus mutans UA159

90.254

100

0.903
  micA Streptococcus pneumoniae Cp1015

79.06

99.153

0.784
  covR Streptococcus salivarius strain HSISS4

44.828

98.305

0.441
  covR Lactococcus lactis subsp. lactis strain DGCC12653

44.397

98.305

0.436
  scnR Streptococcus mutans UA159

36.91

98.729

0.364