Detailed information    

insolico Bioinformatically predicted

Overview

Name   comA   Type   Regulator
Locus tag   L6411_RS00365 Genome accession   NZ_AP025333
Coordinates   54377..56530 (+) Length   717 a.a.
NCBI ID   WP_120171173.1    Uniprot ID   -
Organism   Streptococcus ruminantium strain GUT-189     
Function   processing and transport of ComC (predicted from homology)   
Competence regulation

Genomic Context

Location: 49377..61530
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L6411_RS00310 (GUT189_00430) - 50457..50600 (+) 144 WP_155962526.1 hypothetical protein -
  L6411_RS00315 (GUT189_00440) - 50653..50841 (+) 189 WP_024533071.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  L6411_RS00320 (GUT189_00450) - 51051..51233 (+) 183 WP_024533150.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  L6411_RS00325 (GUT189_00460) - 51318..51491 (+) 174 WP_155962528.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  L6411_RS00330 (GUT189_00470) - 51656..51808 (+) 153 WP_155962529.1 hypothetical protein -
  L6411_RS09925 - 52475..52606 (+) 132 WP_257875343.1 hypothetical protein -
  L6411_RS00335 (GUT189_00480) - 52816..53010 (+) 195 WP_155963542.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  L6411_RS00340 (GUT189_00490) - 53025..53213 (+) 189 WP_155963541.1 hypothetical protein -
  L6411_RS00345 (GUT189_00500) - 53217..53372 (+) 156 WP_155963540.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  L6411_RS00350 (GUT189_00510) - 53426..53617 (+) 192 WP_024533166.1 hypothetical protein -
  L6411_RS00355 (GUT189_00520) - 53731..53898 (+) 168 WP_237374188.1 class IIb bacteriocin, lactobin A/cerein 7B family -
  L6411_RS00360 - 53885..54031 (+) 147 WP_156019613.1 hypothetical protein -
  L6411_RS00365 (GUT189_00530) comA 54377..56530 (+) 2154 WP_120171173.1 peptide cleavage/export ABC transporter ComA Regulator
  L6411_RS00370 (GUT189_00540) comB 56536..57906 (+) 1371 WP_336512685.1 bacteriocin secretion accessory protein Regulator
  L6411_RS00375 (GUT189_00550) ruvB 58337..59335 (+) 999 WP_024532316.1 Holliday junction branch migration DNA helicase RuvB -
  L6411_RS00380 (GUT189_00560) - 59507..60130 (+) 624 WP_155962542.1 HAD-IA family hydrolase -
  L6411_RS00385 (GUT189_00570) comR 60233..61135 (+) 903 WP_155966071.1 helix-turn-helix domain-containing protein Regulator

Sequence

Protein


Download         Length: 717 a.a.        Molecular weight: 80966.11 Da        Isoelectric Point: 7.0769

>NTDB_id=91210 L6411_RS00365 WP_120171173.1 54377..56530(+) (comA) [Streptococcus ruminantium strain GUT-189]
MKFRKRHYRAQVDTRDCGVAALAMILEYHHSHHSLASLRELAKTTMEGTTAFGLVKVAEDLGLETRAIRADMSLFEVGDL
TYPFIAHVLKDGKLMHYYVVTGADEKTIHIADPDPSVKLTKLTRERFEQEWTGVSLFMAPRPEYQPHKEKKQGLLSFVPL
LAKQKRLIGNIILATLLVTLINIVGSYYLQSIIDTYVPNQMKTTLGVISIGLVVVYALQQLLSYAQEYLLIILGQRLSID
VILSYIRHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSIILIISVVLFSQNIYLFFIALLSLPIYSV
IIFAFMKPFERMNQEVMETNAVLSSSIIEDINGIETIKSLTSEKQRYQKIDKEFVDYLKKSFAYNKAEGQQKVLKRLAQL
VLNVAILWLGATLVMDNKMTLGQLITFNTLLVYFTNPLENIINLQTKLQTARVANNRLNEVYLVESEFADQKTVTDLSLV
SGDIDFRDVSYKYGYGADVLSDINLTIKRGEKISFVGVSGSGKTTLAKMMVNFYDPYKGEINLNNVNLNQIDKHALRQHI
NYLPQQPYIFNGTILENLLLGAKEGTTQEDVLRAVEIACIREDIEKMPLNYQTELTSDGSGISGGQRQRIALARALLTDA
PIMILDEATSSLDILTEKRIVDNLLALDKTLIFIVHRLTIAERTERVVVLDKGKIVEQGCHRELLDQQGFYAHLVNS

Nucleotide


Download         Length: 2154 bp        

>NTDB_id=91210 L6411_RS00365 WP_120171173.1 54377..56530(+) (comA) [Streptococcus ruminantium strain GUT-189]
ATGAAGTTTAGGAAACGGCATTATAGGGCTCAGGTGGATACACGAGATTGTGGTGTAGCCGCTCTTGCAATGATTTTGGA
GTACCATCATTCTCATCATTCTTTGGCAAGTCTTCGAGAACTGGCTAAAACAACCATGGAAGGAACGACAGCATTTGGAC
TAGTTAAAGTAGCTGAAGACTTGGGGCTTGAAACTCGCGCAATTCGAGCAGATATGTCCTTATTTGAGGTGGGAGATTTA
ACTTATCCCTTCATAGCTCATGTACTGAAAGATGGCAAGCTCATGCATTACTACGTTGTTACGGGTGCGGATGAGAAGAC
CATCCATATTGCAGATCCAGATCCTTCGGTCAAGTTAACTAAGTTAACTCGTGAACGATTTGAACAGGAATGGACAGGGG
TATCCTTATTCATGGCTCCTAGACCGGAATATCAACCTCACAAAGAGAAGAAGCAAGGCTTGTTGTCTTTTGTTCCCTTG
CTGGCAAAGCAAAAGAGATTGATTGGCAATATTATTTTGGCTACTCTTTTGGTGACGCTCATCAATATTGTTGGATCTTA
TTATCTACAATCCATCATTGATACCTATGTTCCAAATCAGATGAAGACAACTTTGGGAGTTATCTCAATTGGTTTAGTTG
TGGTGTATGCCTTGCAACAGTTGCTGTCTTACGCACAAGAGTATCTGCTCATTATACTGGGGCAAAGACTATCTATAGAT
GTTATCCTATCTTATATCAGACATGTATTCCATTTGCCAATGTCTTTTTTTGCAACACGGCGCACAGGGGAAATCGTTTC
TCGCTTTACAGATGCAAACTCTATTATTGATGCTTTGGCAAGTACAATTCTATCTATTTTCTTAGATGTATCCATTATTT
TGATTATTTCGGTTGTCTTATTTAGTCAGAACATTTACTTGTTTTTTATAGCTTTGTTGTCATTGCCGATTTATTCTGTC
ATTATTTTTGCATTTATGAAGCCATTTGAACGCATGAATCAGGAAGTAATGGAAACAAATGCTGTTTTGTCTTCTTCTAT
TATTGAAGACATCAATGGCATTGAAACAATTAAATCATTGACCAGTGAAAAACAACGTTATCAGAAAATTGATAAAGAAT
TTGTAGACTATCTGAAAAAATCTTTTGCCTATAACAAGGCAGAAGGACAACAAAAAGTGTTAAAGCGCTTGGCTCAGCTA
GTGCTGAACGTGGCTATTTTGTGGTTGGGAGCAACTCTCGTCATGGACAATAAGATGACGCTCGGTCAGCTCATCACGTT
CAATACCTTATTGGTCTACTTCACTAATCCTCTGGAAAATATTATCAATCTACAAACAAAACTTCAAACAGCTCGTGTAG
CAAATAATCGTCTCAATGAAGTTTATTTAGTTGAATCTGAGTTTGCGGATCAAAAGACAGTCACTGACTTGTCCCTGGTT
TCAGGAGATATTGATTTTAGAGATGTTAGTTATAAATATGGGTATGGTGCAGATGTCTTGTCAGACATCAATTTGACAAT
CAAGCGTGGTGAGAAGATTTCTTTTGTCGGAGTTTCTGGATCTGGTAAAACAACGCTGGCTAAGATGATGGTAAATTTTT
ATGATCCTTATAAGGGGGAGATTAACTTGAACAATGTAAATCTCAACCAAATTGACAAGCATGCTTTGCGTCAGCACATC
AATTACTTACCACAACAACCCTATATTTTTAATGGAACTATTTTAGAGAATCTCTTGCTAGGTGCCAAAGAGGGGACCAC
TCAGGAGGATGTCTTGCGAGCAGTAGAAATTGCCTGCATCAGAGAAGACATTGAAAAAATGCCTCTGAATTATCAGACGG
AGCTGACATCGGATGGATCAGGTATATCGGGTGGTCAACGCCAGCGCATCGCTCTGGCTCGAGCGTTGTTGACAGATGCT
CCGATTATGATTTTGGATGAGGCTACCAGTAGTTTAGACATCCTGACGGAGAAGCGAATTGTTGATAATTTGCTCGCCTT
GGATAAGACATTGATTTTTATTGTTCATCGTCTAACCATTGCAGAACGAACAGAGCGTGTCGTTGTACTTGATAAGGGAA
AAATTGTGGAACAAGGTTGTCATAGAGAATTACTCGATCAACAGGGATTTTATGCACATTTAGTAAATAGTTAG

Domains

Predicted by InterproScan.

ABC transporter (ABC_tran)

(500-650)

Peptidase C39 family (Peptidase_C39)

(7-142)

ABC transporter transmembrane region (ABC_membrane)

(170-438)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comA Streptococcus mitis NCTC 12261

81.172

100

0.812
  comA Streptococcus pneumoniae Rx1

81.032

100

0.81
  comA Streptococcus pneumoniae D39

81.032

100

0.81
  comA Streptococcus pneumoniae R6

81.032

100

0.81
  comA Streptococcus mitis SK321

80.893

100

0.809
  comA Streptococcus pneumoniae TIGR4

80.753

100

0.808
  comA Streptococcus gordonii str. Challis substr. CH1

78.103

100

0.781
  comA/nlmT Streptococcus mutans UA159

63.877

100

0.639

Multiple sequence alignment