Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   L6419_RS07560 Genome accession   NZ_AP025332
Coordinates   1590111..1590815 (-) Length   234 a.a.
NCBI ID   WP_120171458.1    Uniprot ID   A0A2Z5TP69
Organism   Streptococcus ruminantium strain GUT-184     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 1585111..1595815
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  L6419_RS07545 (GUT184_14530) pbp2b 1585661..1587736 (-) 2076 WP_024532079.1 penicillin-binding protein PBP2B -
  L6419_RS07550 (GUT184_14540) vicX 1587959..1588762 (-) 804 WP_024532080.1 MBL fold metallo-hydrolase Regulator
  L6419_RS07555 (GUT184_14550) micB 1588769..1590118 (-) 1350 WP_024532081.1 cell wall metabolism sensor histidine kinase VicK Regulator
  L6419_RS07560 (GUT184_14560) micA 1590111..1590815 (-) 705 WP_120171458.1 response regulator YycF Regulator
  L6419_RS07565 (GUT184_14570) - 1591010..1591771 (+) 762 WP_237375267.1 amino acid ABC transporter ATP-binding protein -
  L6419_RS07570 (GUT184_14580) - 1591781..1592617 (+) 837 WP_237375268.1 transporter substrate-binding domain-containing protein -
  L6419_RS07575 (GUT184_14590) - 1592632..1593330 (+) 699 WP_155961912.1 amino acid ABC transporter permease -
  L6419_RS07580 (GUT184_14600) - 1593343..1594002 (+) 660 WP_120171455.1 amino acid ABC transporter permease -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26830.85 Da        Isoelectric Point: 5.2517

>NTDB_id=91198 L6419_RS07560 WP_120171458.1 1590111..1590815(-) (micA) [Streptococcus ruminantium strain GUT-184]
MKKILIVDDEKPISDIIKFNMTREGYEVVTAFDGREALETFEKEFPDVVILDVMLPELDGLEVARTIRKTSNVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSELTETQVNLSSTSTSELVIGDLVILPDAFVAKKHGRELELT
HREFELLHHLAKHLGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYFIKGNV

Nucleotide


Download         Length: 705 bp        

>NTDB_id=91198 L6419_RS07560 WP_120171458.1 1590111..1590815(-) (micA) [Streptococcus ruminantium strain GUT-184]
ATGAAAAAAATACTAATTGTAGATGATGAAAAACCAATCTCAGATATTATCAAATTTAATATGACCCGTGAAGGATATGA
AGTAGTGACAGCTTTTGACGGTCGTGAAGCACTGGAGACATTTGAGAAGGAATTTCCAGATGTTGTTATTTTGGATGTGA
TGTTGCCGGAGTTAGATGGACTAGAAGTGGCTCGAACAATCCGCAAGACTAGCAATGTTCCTATACTAATGCTATCAGCT
AAGGATAGCGAGTTTGATAAGGTTATCGGTCTTGAACTTGGTGCGGATGACTATGTGACAAAGCCCTTCTCTAATCGTGA
ATTACAGGCGCGTGTTAAGGCTCTTCTTCGTCGCAGTGAATTGACAGAAACGCAAGTTAATCTTTCTTCCACAAGTACCT
CAGAGTTAGTTATTGGGGACTTAGTTATCTTGCCAGATGCTTTTGTGGCTAAAAAACATGGTAGGGAATTGGAGTTGACT
CATCGTGAGTTCGAATTGCTTCATCATCTAGCTAAGCATTTGGGTCAGGTGATGACCCGCGAGCATTTGCTGGAAACTGT
GTGGGGCTACGATTATTTTGGTGATGTTCGTACAGTGGATGTGACCATTCGCCGTCTGCGGGAGAAGATTGAAGATACGC
CAAGCAGACCTGAGTACATCCTGACCCGTCGAGGTGTAGGATATTTTATAAAGGGAAATGTTTAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A2Z5TP69

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

80.769

100

0.808
  vicR Streptococcus mutans UA159

79.399

99.573

0.791
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.075

100

0.389

Multiple sequence alignment