Detailed information NTG0091157

Bioinformatically predicted

Overview

• Name: comA
• Type: Regulator
• Locus tag: L6419_RS00370
• Genome accession: NZ_AP025332
• Coordinates: 56880..59033 (+)
• Length: 717 a.a.
• NCBI ID: WP_237375472.1
• Uniprot ID: -
• Organism: Streptococcus ruminantium strain GUT-184
• Function: processing and transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 51880..64033

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
L6419_RS00320 (GUT184_00450)	-	52973..53116 (+)	144	WP_237375469.1	hypothetical protein	-
L6419_RS00325 (GUT184_00460)	-	53169..53357 (+)	189	WP_155962527.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
L6419_RS00330 (GUT184_00470)	-	53566..53748 (+)	183	WP_024533150.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
L6419_RS00335 (GUT184_00480)	-	53832..54005 (+)	174	WP_155962528.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
L6419_RS00340 (GUT184_00490)	-	54170..54322 (+)	153	WP_155962529.1	hypothetical protein	-
L6419_RS00345 (GUT184_00500)	-	55320..55514 (+)	195	WP_155963542.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
L6419_RS00350 (GUT184_00510)	-	55529..55717 (+)	189	WP_155963541.1	hypothetical protein	-
L6419_RS00355 (GUT184_00520)	-	55721..55876 (+)	156	WP_156020754.1	class IIb bacteriocin, lactobin A/cerein 7B family	-
L6419_RS00360 (GUT184_00530)	-	55931..56122 (+)	192	WP_024533166.1	hypothetical protein	-
L6419_RS00365	-	56388..56534 (+)	147	WP_237375471.1	hypothetical protein	-
L6419_RS00370 (GUT184_00540)	comA	56880..59033 (+)	2154	WP_237375472.1	peptide cleavage/export ABC transporter ComA	Regulator
L6419_RS00375 (GUT184_00550)	comB	59039..60409 (+)	1371	WP_336512672.1	bacteriocin secretion accessory protein	Regulator
L6419_RS00380 (GUT184_00560)	ruvB	60840..61838 (+)	999	WP_024532316.1	Holliday junction branch migration DNA helicase RuvB	-
L6419_RS00385 (GUT184_00570)	-	62010..62633 (+)	624	WP_237375766.1	HAD-IA family hydrolase	-
L6419_RS00390 (GUT184_00580)	comR	62736..63635 (+)	900	WP_024532318.1	helix-turn-helix domain-containing protein	Regulator

Sequence

Protein

• Length: 717 a.a.
• Molecular weight: 80978.17 Da
• Isoelectric Point: 7.0769

>NTDB_id=91157 L6419_RS00370 WP_237375472.1 56880..59033(+) (comA) [Streptococcus ruminantium strain GUT-184]
MKFRKRHYRAQVDTRDCGVAALAMILEYHHSHHSLASLRELAKTTMEGTTAFGLVKVAEDLGLETRAIRADMSLFEVGDL
TYPFIAHVLKDGKLMHYYVVTGADEKTIHIADPDPSVKLTKLTRERFEQEWTGVSLFMAPRPEYQPHKEKKQGLLSFVPL
LAKQKRLIGNIILATLLVTLINIVGSYYLQSIIDTYVPNQMKTTLGVISIGLVVVYALQQLLSYAQEYLLIILGQRLSID
VILSYIRHVFHLPMSFFATRRTGEIVSRFTDANSIIDALASTILSIFLDVSIILIISVVLFSQNIYLFFIALLSLPIYSV
IIFAFMKPFERMNQEVMETNAVLSSSIIEDINGIETIKSLTSEKQRYQKIDKEFVDYLKKSFAYNKAEGQQKVLKRLAQL
VLNVAILWLGATLVMDNKMTLGQLITFNTLLVYFTNPLENIINLQTKLQTARVANNRLNEVYLVESEFADQKTVTDLSLV
SGDIDFRDVSYKYGYGADVLSDINLTIKRGEKISFVGVSGSGKTTLAKMMVNFYDPYKGEINLNNVNLNQIDKHALRQHI
NYLPQQPYIFNGTILENLLLGAKEGTTQEDVLRAVEIACIREDIEKMPLNYQTELISDGSGISGGQRQRIALARALLTDA
PIMILDEATSSLDILTEKRIVDNLLALDKTLIFIVHRLTIAERTERVVVLDKGKIVEQGCHRELLDQQGFYAHLVNS

Nucleotide

• Length: 2154 bp

>NTDB_id=91157 L6419_RS00370 WP_237375472.1 56880..59033(+) (comA) [Streptococcus ruminantium strain GUT-184]
ATGAAGTTTAGGAAACGGCATTATAGGGCTCAGGTGGATACACGAGATTGTGGTGTAGCCGCTCTTGCAATGATTTTGGA
GTACCATCATTCTCATCATTCTTTGGCAAGTCTTCGAGAACTGGCTAAAACAACCATGGAAGGAACGACAGCATTTGGAC
TAGTTAAAGTAGCTGAAGACTTGGGGCTTGAAACTCGCGCAATTCGAGCAGATATGTCCTTATTTGAGGTGGGAGATTTA
ACTTATCCCTTCATAGCTCATGTACTGAAAGATGGCAAGCTCATGCACTACTACGTTGTTACGGGTGCGGATGAGAAGAC
CATCCATATTGCAGATCCAGATCCTTCGGTCAAGTTAACTAAGTTAACTCGTGAACGATTTGAACAGGAATGGACAGGGG
TATCCTTATTCATGGCTCCTAGACCGGAATATCAACCTCACAAAGAGAAGAAGCAAGGCTTGTTGTCTTTTGTTCCCTTG
CTAGCAAAGCAAAAGAGATTGATTGGCAATATTATTTTGGCTACTCTTTTGGTGACGCTCATCAATATTGTTGGATCTTA
TTATCTACAATCCATCATTGATACCTATGTTCCAAATCAGATGAAGACAACTTTGGGAGTTATCTCAATTGGTTTAGTTG
TGGTGTATGCCTTGCAACAGTTGTTGTCTTACGCACAAGAGTATCTGCTCATTATACTAGGGCAAAGACTATCTATAGAT
GTTATCCTATCTTATATCAGACATGTATTCCATTTGCCAATGTCTTTTTTTGCAACACGGCGCACAGGGGAAATCGTTTC
TCGCTTTACAGATGCAAACTCTATTATTGATGCTTTGGCAAGTACAATTCTATCTATTTTCTTAGATGTATCCATTATTT
TGATTATTTCAGTTGTCTTATTTAGTCAGAATATTTACTTGTTTTTTATAGCTTTGTTGTCATTGCCGATTTATTCTGTC
ATTATTTTTGCATTTATGAAGCCATTTGAACGCATGAATCAGGAAGTAATGGAAACAAATGCTGTTTTGTCTTCTTCTAT
TATTGAAGACATCAATGGCATTGAAACAATTAAATCATTGACCAGTGAAAAACAACGTTATCAGAAAATTGATAAAGAAT
TTGTAGACTATCTGAAAAAATCTTTTGCCTATAACAAGGCAGAAGGACAACAAAAAGTGTTAAAGCGCTTGGCTCAGCTA
GTGCTGAACGTGGCTATTTTGTGGTTGGGAGCAACTCTCGTCATGGACAATAAGATGACGCTCGGTCAGCTCATCACGTT
CAATACCTTATTGGTCTACTTCACTAATCCTCTGGAAAATATTATCAATCTACAAACAAAACTTCAAACAGCTCGTGTAG
CAAATAATCGTCTCAATGAAGTTTATTTAGTTGAATCTGAGTTTGCGGATCAAAAGACAGTCACTGACTTGTCCCTGGTT
TCAGGAGATATTGATTTTAGAGATGTTAGTTATAAATATGGGTATGGTGCAGATGTCTTGTCAGACATCAATTTGACAAT
CAAGCGTGGTGAGAAGATTTCTTTTGTCGGAGTTTCTGGATCTGGTAAAACAACGCTGGCCAAGATGATGGTAAATTTTT
ATGATCCTTATAAGGGGGAGATTAACTTGAACAATGTAAATCTCAACCAAATTGACAAGCATGCTTTGCGTCAGCACATC
AATTACTTACCACAACAACCCTATATTTTTAATGGAACTATTTTAGAGAATCTCTTGCTAGGTGCCAAAGAGGGGACCAC
TCAGGAGGATGTCTTGCGAGCAGTAGAAATTGCCTGCATCAGAGAAGACATTGAAAAAATGCCTCTGAATTATCAGACGG
AGCTGATATCGGATGGATCAGGTATATCGGGTGGTCAACGCCAGCGCATCGCTCTGGCTCGAGCGTTGTTGACAGATGCT
CCGATTATGATTTTGGATGAGGCTACCAGTAGTTTAGACATCCTGACGGAGAAGCGAATTGTTGATAATTTGCTCGCCTT
GGATAAGACATTGATTTTTATTGTTCATCGTCTAACCATTGCGGAACGAACAGAGCGTGTCGTTGTACTTGATAAGGGAA
AAATTGTGGAACAAGGTTGTCATAGGGAACTACTCGATCAACAGGGATTTTATGCACATTTAGTAAATAGTTAG

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

• ABC transporter transmembrane region (ABC_membrane) (170-438)

• ABC transporter (ABC_tran) (500-650)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA	Streptococcus mitis NCTC 12261	81.032	100	0.81
comA	Streptococcus pneumoniae Rx1	80.893	100	0.809
comA	Streptococcus pneumoniae D39	80.893	100	0.809
comA	Streptococcus pneumoniae R6	80.893	100	0.809
comA	Streptococcus mitis SK321	80.753	100	0.808
comA	Streptococcus pneumoniae TIGR4	80.614	100	0.806
comA	Streptococcus gordonii str. Challis substr. CH1	78.103	100	0.781
comA/nlmT	Streptococcus mutans UA159	63.877	100	0.639