Detailed information    

insolico Bioinformatically predicted

Overview

Name   comE/blpR   Type   Regulator
Locus tag   U0450_RS02940 Genome accession   NZ_CP139863
Coordinates   585575..586312 (-) Length   245 a.a.
NCBI ID   WP_001219126.1    Uniprot ID   A7XHJ0
Organism   Streptococcus pneumoniae strain 15P2112     
Function   activate transcription of early competence genes; regulation of comX expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 580575..591312
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  U0450_RS02915 blpA 580951..582219 (+) 1269 Protein_579 peptide cleavage/export ABC transporter BlpA -
  U0450_RS02920 comA/nlmT 582429..582593 (+) 165 WP_306420852.1 hypothetical protein Regulator
  U0450_RS02925 - 582604..583965 (+) 1362 WP_050211505.1 bacteriocin secretion accessory protein -
  U0450_RS02930 blpC 584022..584177 (+) 156 WP_061450964.1 quorum-sensing system pheromone BlpC -
  U0450_RS02935 - 584221..585561 (-) 1341 WP_127244994.1 sensor histidine kinase -
  U0450_RS02940 comE/blpR 585575..586312 (-) 738 WP_001219126.1 response regulator transcription factor Regulator
  U0450_RS02945 - 586317..586655 (-) 339 WP_050115203.1 LytTR family DNA-binding domain-containing protein -
  U0450_RS02950 - 586931..587260 (+) 330 WP_000132572.1 hypothetical protein -
  U0450_RS02955 - 587428..588477 (-) 1050 WP_127244993.1 ABC transporter permease -
  U0450_RS02960 pptA 588474..589205 (-) 732 WP_000889956.1 ABC transporter ATP-binding protein Regulator
  U0450_RS02965 - 589273..589683 (+) 411 WP_001278322.1 HIT family protein -
  U0450_RS02970 - 589693..589980 (+) 288 WP_000777753.1 hypothetical protein -

Sequence

Protein


Download         Length: 245 a.a.        Molecular weight: 28752.92 Da        Isoelectric Point: 6.2357

>NTDB_id=911544 U0450_RS02940 WP_001219126.1 585575..586312(-) (comE/blpR) [Streptococcus pneumoniae strain 15P2112]
MRIFVLEDDFSQQTRIETTIEKLLKAHHIIPSSFEVFGKPDQLLAEVHEKGAHQLFFLDIEIRNEEMKGLEVARKIREQD
PYALIVFVTTHSEFMPLSFRYQVSALDYIDKALSAEEFESRIETALLYANSQDSKSLAEDCFYFKSKFAQFQYPFKEVYY
LETSPRPHRVILYTKTDRLEFTASLEEVFKQEPRLLQCHRSFLINPANVVHLDKKEKLLFFPNGGSCLIARYKVREVSEA
INNLH

Nucleotide


Download         Length: 738 bp        

>NTDB_id=911544 U0450_RS02940 WP_001219126.1 585575..586312(-) (comE/blpR) [Streptococcus pneumoniae strain 15P2112]
ATGAGAATATTTGTTTTAGAAGATGATTTTTCCCAACAGACTAGAATTGAAACGACGATTGAGAAACTTTTGAAAGCACA
TCATATCATTCCTAGCTCTTTTGAGGTATTTGGCAAGCCGGACCAACTGCTGGCAGAGGTGCATGAGAAGGGGGCCCATC
AGCTATTCTTTTTGGATATTGAGATTCGAAATGAAGAGATGAAGGGACTGGAAGTAGCTAGAAAGATTCGGGAACAAGAC
CCTTATGCCCTAATCGTCTTTGTGACGACTCACTCGGAGTTTATGCCTCTGTCCTTTCGCTACCAAGTGTCAGCTTTGGA
CTACATTGATAAGGCCCTTTCGGCAGAGGAGTTTGAATCTCGTATCGAGACAGCCCTCCTCTATGCCAATAGTCAAGATA
GTAAAAGTCTGGCGGAAGATTGCTTTTACTTTAAATCAAAATTTGCCCAATTCCAATATCCTTTCAAAGAGGTTTACTAT
CTCGAAACATCCCCAAGACCCCATCGTGTTATTCTCTATACCAAGACGGACAGGCTAGAATTTACGGCGAGTTTAGAGGA
GGTTTTTAAGCAGGAACCCCGTCTCTTGCAGTGCCATCGCTCTTTTCTCATCAATCCTGCAAATGTGGTGCATTTGGATA
AGAAAGAAAAACTCCTTTTCTTTCCCAATGGTGGAAGCTGTCTGATCGCGCGTTATAAGGTCAGGGAAGTGTCTGAGGCT
ATTAATAACTTACACTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(3-122)

LytTr DNA-binding domain (LytTR)

(151-241)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A7XHJ0

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comE/blpR Streptococcus mutans UA159

53.909

99.184

0.535
  comE/comE1 Streptococcus equinus JB1

43.882

96.735

0.424
  comE/comE2 Streptococcus equinus JB1

38.843

98.776

0.384