Detailed information NTG0911459

Bioinformatically predicted

Overview

• Name: ciaH
• Type: Regulator
• Locus tag: U0449_RS01540
• Genome accession: NZ_CP139862
• Coordinates: 308725..310059 (-)
• Length: 444 a.a.
• NCBI ID: WP_322397846.1
• Uniprot ID: -
• Organism: Streptococcus pneumoniae strain 05H0020-2
• Function: repress competence development; post-transcriptional repression of CSP production (predicted from homology) Competence regulation

Genomic Context

Location: 303725..315059

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
U0449_RS01525	-	304685..307135 (-)	2451	WP_000848700.1	bifunctional DnaQ family exonuclease/ATP-dependent helicase	-
U0449_RS01530	-	307335..308264 (-)	930	WP_000411857.1	peptidase U32 family protein	-
U0449_RS01535	-	308404..308691 (+)	288	WP_001145225.1	DUF3270 domain-containing protein	-
U0449_RS01540	ciaH	308725..310059 (-)	1335	WP_322397846.1	two-component system sensor histidine kinase CiaH	Regulator
U0449_RS01545	ciaR	310049..310723 (-)	675	WP_000590640.1	two-component system response regulator CiaR	Regulator
U0449_RS01550	-	310832..313378 (-)	2547	WP_001149118.1	M1 family metallopeptidase	-
U0449_RS01555	-	313501..313941 (-)	441	WP_000612883.1	ASCH domain-containing protein	-
U0449_RS01560	-	313916..314785 (-)	870	WP_050219028.1	putative PEP-binding protein	-

Sequence

Protein

• Length: 444 a.a.
• Molecular weight: 50659.36 Da
• Isoelectric Point: 9.1661

>NTDB_id=911459 U0449_RS01540 WP_322397846.1 308725..310059(-) (ciaH) [Streptococcus pneumoniae strain 05H0020-2]
MFSKLKKTWYADDFSYFIRNFGVFTLIFSTMTLIILQVMHSSLYTSVDDKLHGLSENPQAVIQLAINRATEEIKDLENAR
ADASKVEIKPNVSSNTEVILFDKDFTQLLSGNRFLGLDKIKLEKKELGHIYQIQVFNSYGQEEIYRVILMETNISSVSTN
IKYAAVLINTSQLEQASQKHEQLIVVVMASFWILSLLASLYLARVSVRPLLESMQKQQSFVENASHELRTPLAVLQNRLE
TLFRKPEATIMDVSESIASSLEEVRNMRFLTTSLLNLARRDDGIKPELAEVPTSFFNTTFTNYEMIASENNRVFRFENRI
HRTIVTDQLLLKQLMTILFDNAVKYTEEDGEIDFLISATDRNLYLLVSDNGIGISTEDKKKIFDRFYRVDKARTRQKGGF
GLGLSLAKQIVDAVKGTVTVKDNKPKGTIFEVKIAIQTPSKKKK

Nucleotide

• Length: 1335 bp

>NTDB_id=911459 U0449_RS01540 WP_322397846.1 308725..310059(-) (ciaH) [Streptococcus pneumoniae strain 05H0020-2]
ATGTTCAGTAAACTTAAAAAAACATGGTATGCGGATGACTTTAGTTATTTTATCCGCAACTTCGGTGTCTTCACCCTGAT
TTTTTCTACAATGACTCTGATTATTTTACAAGTCATGCATTCGAGTCTTTATACTTCGGTGGACGATAAGCTTCATGGAC
TGAGTGAAAATCCTCAAGCAGTTATTCAGCTGGCTATAAATAGGGCAACAGAAGAGATTAAAGATTTAGAAAATGCTAGG
GCGGACGCTAGTAAAGTAGAAATAAAACCTAATGTCAGTTCCAATACGGAAGTTATTCTCTTTGATAAGGACTTTACTCA
ACTTCTTTCTGGAAATCGATTTTTGGGCTTGGATAAGATTAAGTTAGAAAAGAAAGAACTAGGACATATCTACCAGATTC
AGGTTTTTAATAGCTATGGGCAGGAAGAAATCTATCGTGTGATTTTGATGGAGACCAATATTAGTTCGGTTTCAACCAAT
ATCAAGTATGCTGCTGTCTTGATTAATACCAGTCAGTTGGAGCAGGCTAGTCAAAAGCATGAGCAATTGATTGTGGTCGT
GATGGCTAGTTTCTGGATTTTGTCTTTACTTGCCAGTCTCTATCTAGCTAGGGTCAGTGTTAGGCCCCTGCTTGAGAGTA
TGCAGAAGCAACAGTCTTTTGTGGAAAATGCCAGTCATGAGTTACGAACTCCACTCGCAGTTTTGCAAAATCGCTTAGAG
ACCCTTTTTCGTAAGCCAGAAGCTACCATTATGGATGTGAGCGAAAGCATTGCATCGAGTTTGGAAGAAGTCCGAAATAT
GCGTTTTTTAACGACAAGCTTGCTGAACTTAGCTCGGAGAGATGATGGGATTAAGCCGGAGCTTGCAGAAGTTCCAACTA
GCTTTTTTAATACAACTTTCACAAACTATGAGATGATTGCTTCGGAAAATAATCGTGTCTTCCGTTTTGAAAATCGTATC
CATCGAACAATTGTCACAGATCAGCTTCTTCTGAAACAACTGATGACCATTCTTTTCGATAATGCCGTCAAGTATACTGA
GGAGGATGGTGAAATTGATTTTCTTATCTCGGCGACCGATCGCAATCTTTATTTACTTGTTTCTGATAATGGAATCGGTA
TTTCGACAGAAGATAAAAAGAAAATTTTTGACCGTTTTTATCGAGTAGACAAGGCTAGAACCCGGCAAAAAGGTGGTTTT
GGTTTAGGATTATCCCTAGCCAAGCAAATTGTAGATGCTGTAAAAGGAACTGTTACTGTCAAAGATAATAAACCCAAGGG
AACAATCTTTGAAGTGAAGATTGCCATTCAGACACCATCTAAAAAGAAAAAATAA

Domains

Predicted by InterproScan.

• His Kinase A (phospho-acceptor) domain (HisKA) (217-283)

• Histidine kinase-, DNA gyrase B-, and HSP90-like ATPase (HATPase_c) (327-434)

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
ciaH	Streptococcus pneumoniae Rx1	99.775	100	0.998
ciaH	Streptococcus pneumoniae D39	99.775	100	0.998
ciaH	Streptococcus pneumoniae R6	99.775	100	0.998
ciaH	Streptococcus pneumoniae TIGR4	99.775	100	0.998
ciaH	Streptococcus mutans UA159	55.402	97.973	0.543