Detailed information NTG0896288

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: R4705_RS07850
• Genome accession: NZ_CP137115
• Coordinates: 1491649..1492236 (-)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain 20614-6
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1486649..1497236

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4705_RS07820	-	1487111..1488451 (+)	1341	WP_001017622.1	sensor histidine kinase	-
R4705_RS07825	blpC	1488493..1488648 (-)	156	WP_000358813.1	quorum-sensing system pheromone BlpC	-
R4705_RS07830	-	1488705..1490066 (-)	1362	WP_001069092.1	bacteriocin secretion accessory protein	-
R4705_RS07835	comA/nlmT	1490077..1490565 (-)	489	WP_307774349.1	ATP-binding cassette domain-containing protein	Regulator
R4705_RS07840	comA/nlmT	1490549..1490989 (-)	441	WP_001808911.1	ATP-binding cassette domain-containing protein	Regulator
R4705_RS07845	comA/nlmT	1490979..1491704 (-)	726	WP_167750760.1	ABC transporter transmembrane domain-containing protein	Regulator
R4705_RS07850	comA/nlmT	1491649..1492236 (-)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
R4705_RS07855	blpI	1492518..1492715 (+)	198	WP_001093259.1	bacteriocin-like peptide BlpI	-
R4705_RS07860	cipB	1493182..1493331 (+)	150	WP_001808912.1	bacteriocin-like peptide BlpO	Regulator
R4705_RS07865	-	1493435..1493554 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
R4705_RS07870	-	1494340..1494723 (+)	384	WP_000877381.1	hypothetical protein	-
R4705_RS07875	-	1494775..1495464 (+)	690	WP_000760526.1	CPBP family intramembrane glutamic endopeptidase	-
R4705_RS07880	blpZ	1495506..1495754 (+)	249	WP_000276499.1	immunity protein BlpZ	-
R4705_RS07885	-	1495784..1496395 (+)	612	WP_000394045.1	CPBP family intramembrane glutamic endopeptidase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=896288 R4705_RS07850 WP_000205166.1 1491649..1492236(-) (comA/nlmT) [Streptococcus pneumoniae strain 20614-6]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=896288 R4705_RS07850 WP_000205166.1 1491649..1492236(-) (comA/nlmT) [Streptococcus pneumoniae strain 20614-6]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497