Detailed information    

insolico Bioinformatically predicted

Overview

Name   htrA   Type   Regulator
Locus tag   R4705_RS05465 Genome accession   NZ_CP137115
Coordinates   1032788..1033969 (+) Length   393 a.a.
NCBI ID   WP_000681597.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 20614-6     
Function   degrading CSP; selective degradation of ComEA and ComEC (predicted from homology)   
Competence regulation

Genomic Context

Location: 1027788..1038969
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4705_RS05425 - 1028838..1029380 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  R4705_RS05440 comE 1029623..1030375 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  R4705_RS05445 comD/comD1 1030372..1031697 (-) 1326 WP_015511364.1 competence system sensor histidine kinase ComD Regulator
  R4705_RS05450 comC/comC1 1031718..1031843 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  R4705_RS05460 rlmH 1032126..1032605 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R4705_RS05465 htrA 1032788..1033969 (+) 1182 WP_000681597.1 S1C family serine protease Regulator
  R4705_RS05470 spo0J 1034027..1034785 (+) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator
  R4705_RS05475 dnaA 1034998..1036359 (+) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -
  R4705_RS05480 dnaN 1036518..1037654 (+) 1137 WP_000581155.1 DNA polymerase III subunit beta -
  R4705_RS05485 - 1037719..1037913 (+) 195 WP_000285194.1 DUF951 domain-containing protein -

Sequence

Protein


Download         Length: 393 a.a.        Molecular weight: 41841.72 Da        Isoelectric Point: 6.8902

>NTDB_id=896273 R4705_RS05465 WP_000681597.1 1032788..1033969(+) (htrA) [Streptococcus pneumoniae strain 20614-6]
MKHLKTFYKKWFQLLVVIVISFFSGALGSFSITQLTQKSSVNNSNNNSTITQTAYKNENSTTQAVNKVKDAVVSVITYSA
NRQNSVFGNDDTDTDSQRISSEGSGVIYKKNDKEAYIVTNNHVINGASKVDIRLSDGTKVPGEIVGADTFSDIAVVKISS
EKVTTVAEFGDSSKLTVGETAIAIGSPLGSEYANTVTQGIVSSLNRNVSLKSEDGQAISTKAIQTDTAINPGNSGGPLIN
IQGQVIGITSSKIATNGGTSVEGLGFAIPANDAINIIEQLEKNGKVTRPALGIQMVNLSNVSTSDIRRLNIPSNVTSGVI
VRSVQSNMPANGHLEKYDVITKVDDKEIASSTDLQSALYNHSIGDTIKITYYRNGKEETTSIKLNKSSGDLES

Nucleotide


Download         Length: 1182 bp        

>NTDB_id=896273 R4705_RS05465 WP_000681597.1 1032788..1033969(+) (htrA) [Streptococcus pneumoniae strain 20614-6]
ATGAAACATCTAAAAACATTTTACAAAAAATGGTTTCAATTATTAGTCGTTATCGTCATTAGCTTTTTTAGTGGAGCCTT
GGGTAGTTTTTCAATAACTCAACTAACTCAAAAAAGTAGTGTAAACAACTCTAACAACAATAGTACTATTACACAAACTG
CCTATAAGAACGAAAATTCAACAACACAGGCCGTTAACAAAGTAAAAGATGCTGTTGTTTCTGTTATTACTTATTCGGCA
AACAGACAAAATAGCGTATTTGGCAATGATGATACTGACACAGATTCTCAGCGAATCTCTAGTGAAGGATCTGGAGTTAT
TTATAAAAAGAATGATAAAGAAGCTTACATCGTCACCAACAATCACGTTATAAATGGCGCCAGCAAAGTAGATATTCGAT
TGTCAGATGGGACTAAAGTACCTGGAGAAATTGTCGGAGCTGACACTTTCTCTGATATTGCTGTCGTCAAAATCTCTTCA
GAAAAAGTGACAACAGTAGCTGAGTTTGGTGATTCTAGTAAGTTAACTGTAGGAGAAACTGCTATTGCCATCGGTAGCCC
GTTAGGTTCTGAATATGCAAATACTGTCACTCAAGGTATCGTATCCAGTCTCAATAGAAATGTATCCTTAAAATCGGAAG
ATGGACAAGCTATTTCTACAAAAGCCATCCAAACTGATACTGCTATTAACCCAGGTAACTCTGGCGGCCCACTGATCAAT
ATTCAAGGGCAGGTTATCGGAATTACCTCAAGTAAAATTGCTACAAATGGAGGAACATCTGTAGAAGGTCTTGGTTTCGC
AATTCCTGCAAATGATGCTATCAATATTATTGAACAGTTAGAAAAAAACGGAAAAGTGACGCGTCCAGCTTTGGGAATCC
AGATGGTTAATTTATCTAATGTGAGTACAAGCGACATCAGAAGACTCAATATTCCAAGTAATGTTACATCTGGTGTAATT
GTTCGTTCGGTACAAAGTAATATGCCTGCCAATGGTCACCTTGAAAAATACGATGTAATTACAAAAGTAGATGACAAAGA
GATTGCTTCATCAACAGACTTACAAAGTGCTCTTTACAACCATTCTATCGGAGACACCATTAAGATAACCTACTATCGTA
ACGGGAAAGAAGAAACTACCTCTATCAAACTTAACAAGAGTTCAGGTGATTTAGAATCTTAA

Domains

Predicted by InterproScan.

Trypsin-like peptidase domain (Trypsin_2)

(103-248)

PDZ domain (PDZ_2)

(289-384)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  htrA Streptococcus pneumoniae Rx1

100

100

1
  htrA Streptococcus pneumoniae D39

100

100

1
  htrA Streptococcus pneumoniae R6

100

100

1
  htrA Streptococcus pneumoniae TIGR4

100

100

1
  htrA Streptococcus mitis NCTC 12261

97.201

100

0.972
  htrA Streptococcus gordonii str. Challis substr. CH1

66.414

100

0.669
  htrA Streptococcus mutans UA159

54.569

100

0.547