Detailed information    

insolico Bioinformatically predicted

Overview

Name   comD/comD1   Type   Regulator
Locus tag   R4705_RS05445 Genome accession   NZ_CP137115
Coordinates   1030372..1031697 (-) Length   441 a.a.
NCBI ID   WP_015511364.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain 20614-6     
Function   phosphorylation of ComE (predicted from homology)   
Competence regulation

Genomic Context

Location: 1025372..1036697
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4705_RS05420 - 1027056..1028659 (-) 1604 Protein_1025 YhgE/Pip family protein -
  R4705_RS05425 - 1028838..1029380 (+) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  R4705_RS05440 comE 1029623..1030375 (-) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  R4705_RS05445 comD/comD1 1030372..1031697 (-) 1326 WP_015511364.1 competence system sensor histidine kinase ComD Regulator
  R4705_RS05450 comC/comC1 1031718..1031843 (-) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  R4705_RS05460 rlmH 1032126..1032605 (-) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R4705_RS05465 htrA 1032788..1033969 (+) 1182 WP_000681597.1 S1C family serine protease Regulator
  R4705_RS05470 spo0J 1034027..1034785 (+) 759 WP_000410383.1 ParB/RepB/Spo0J family partition protein Regulator
  R4705_RS05475 dnaA 1034998..1036359 (+) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -

Sequence

Protein


Download         Length: 441 a.a.        Molecular weight: 51187.66 Da        Isoelectric Point: 6.9339

>NTDB_id=896271 R4705_RS05445 WP_015511364.1 1030372..1031697(-) (comD/comD1) [Streptococcus pneumoniae strain 20614-6]
MDLFGFGTVIVHFLIISHSYHLICKGQINRKELFVFGAYTLLTEIVFDFPLYILYLDGLGIATFLFPLGLYSYFRWIKQY
ERDRGLFLSLLLSLLYESTHNFLSVTFSSITGDNFVLQYHFPFFFVVTVLTYFVTLKIIYYFHLELAYFDKDYLYPFLKK
VFFALLLLHIVSFVSDMVSTIKHLNSFGSILSSIVFISLLLTFFAMNSHKVQMEKEIALKQKKFEQKHLQNYTDEIVGLY
NEIRGFRHDYAGMLVSMQMAIDSGNLQEIDRIYNEVLVKANHKLRSDKYTYFDLNNIEDSALRSLVAQSIVYARNNGVEF
TLEVKDTITKLPIELLDLVRIMSVLLNNAVEGSADSYKKQMEVAVIKMETETVIVIQNSCKMTMTPSGDLFALGFSTKGR
NRGVGLNNVKELLDKYNNIILETEMEGSTFRQIIRFKREFE

Nucleotide


Download         Length: 1326 bp        

>NTDB_id=896271 R4705_RS05445 WP_015511364.1 1030372..1031697(-) (comD/comD1) [Streptococcus pneumoniae strain 20614-6]
ATGGATTTATTTGGATTTGGGACAGTTATTGTTCATTTTTTAATTATTAGTCACAGCTACCATTTAATTTGTAAAGGTCA
AATAAATAGAAAAGAATTATTCGTTTTTGGTGCTTATACATTACTAACAGAAATAGTATTTGATTTTCCCTTATATATTC
TATATTTAGATGGGTTAGGGATTGCAACATTTTTATTTCCTTTGGGCCTATATTCCTATTTTCGATGGATAAAACAGTAT
GAGAGGGATAGAGGACTATTCCTAAGTTTACTACTATCTCTTTTATATGAGAGCACTCATAACTTTCTGTCCGTAACTTT
CTCCTCTATAACAGGAGATAATTTTGTTTTACAATATCATTTCCCATTCTTTTTCGTTGTGACGGTGTTGACCTATTTTG
TTACATTAAAAATCATTTATTATTTCCATTTGGAACTAGCCTATTTTGACAAGGACTACCTTTATCCTTTCTTGAAAAAA
GTATTTTTTGCTTTACTATTGCTACATATTGTATCTTTCGTTTCAGATATGGTAAGTACGATTAAACATTTGAATAGTTT
TGGAAGTATTTTGTCATCTATTGTCTTTATCTCTCTCCTTTTGACCTTCTTTGCAATGAATTCTCATAAAGTTCAAATGG
AGAAAGAGATTGCTTTGAAGCAGAAGAAATTTGAACAGAAACATTTACAGAATTACACAGATGAAATTGTTGGTCTGTAT
AATGAAATCCGTGGTTTTCGACATGATTATGCTGGAATGCTTGTCAGCATGCAGATGGCAATTGACAGTGGTAATTTACA
GGAAATTGACAGAATTTACAATGAAGTTTTAGTCAAAGCAAATCATAAATTGCGTTCAGATAAGTACACTTACTTTGATT
TGAACAACATAGAAGACTCAGCTTTACGAAGTTTGGTTGCTCAGTCAATTGTCTATGCTCGAAATAATGGTGTAGAGTTT
ACACTGGAAGTAAAAGATACGATTACCAAGCTTCCAATTGAACTATTGGATTTGGTTCGTATCATGAGCGTTTTATTGAA
TAATGCTGTCGAAGGATCGGCTGATAGCTATAAAAAGCAGATGGAAGTAGCAGTTATTAAGATGGAAACTGAAACAGTTA
TTGTGATTCAGAATTCATGTAAAATGACGATGACTCCTTCAGGAGATCTATTTGCCTTAGGATTCTCCACTAAGGGAAGA
AATCGCGGAGTCGGATTAAATAATGTGAAAGAACTACTAGATAAGTACAACAATATTATTTTAGAAACAGAGATGGAAGG
CAGTACATTTAGACAAATCATTAGATTTAAGAGGGAATTTGAATGA

Domains

Predicted by InterproScan.

GHKL domain (HATPase_c_5)

(334-434)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comD/comD1 Streptococcus pneumoniae Rx1

98.866

100

0.989
  comD/comD1 Streptococcus pneumoniae D39

98.866

100

0.989
  comD/comD1 Streptococcus pneumoniae R6

98.866

100

0.989
  comD/comD2 Streptococcus pneumoniae TIGR4

96.599

100

0.966
  comD Streptococcus mitis SK321

92.744

100

0.927
  comD Streptococcus mitis NCTC 12261

86.621

100

0.866
  comD/comD1 Streptococcus gordonii str. Challis substr. CH1

49.468

85.261

0.422
  comD/comD2 Streptococcus gordonii strain NCTC7865

49.202

85.261

0.42