Detailed information    

insolico Bioinformatically predicted

Overview

Name   clpP   Type   Regulator
Locus tag   R4712_RS01920 Genome accession   NZ_CP137110
Coordinates   387425..388015 (-) Length   196 a.a.
NCBI ID   WP_000613477.1    Uniprot ID   A0A064BX72
Organism   Streptococcus pneumoniae strain 16H2041     
Function   degradation of ComX; degradation of ComW (predicted from homology)   
Competence regulation

Related MGE

Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
ICE 354378..392776 387425..388015 within 0


Gene organization within MGE regions


Location: 354378..392776
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4712_RS01735 gor 355384..356730 (+) 1347 WP_001209596.1 glutathione-disulfide reductase -
  R4712_RS01740 - 356927..357463 (+) 537 WP_000709036.1 biotin transporter BioY -
  R4712_RS01745 - 357525..357671 (+) 147 WP_001809980.1 hypothetical protein -
  R4712_RS01750 - 357668..357883 (-) 216 WP_000807422.1 YdbC family protein -
  R4712_RS01755 - 357935..358888 (-) 954 WP_044812860.1 IS30-like element ISSpn8 family transposase -
  R4712_RS01760 - 359226..359546 (+) 321 WP_001216099.1 hypothetical protein -
  R4712_RS01765 - 359577..359915 (-) 339 WP_001196049.1 ATP cone domain-containing protein -
  R4712_RS01770 trmD 359927..360646 (-) 720 WP_000686921.1 tRNA (guanosine(37)-N1)-methyltransferase TrmD -
  R4712_RS01775 rimM 360636..361154 (-) 519 WP_001105899.1 ribosome maturation factor RimM -
  R4712_RS01780 - 361185..361973 (-) 789 WP_041171613.1 alpha/beta hydrolase -
  R4712_RS01785 - 362077..362361 (-) 285 Protein_353 MazG nucleotide pyrophosphohydrolase domain-containing protein -
  R4712_RS01790 kphA 362549..362788 (-) 240 WP_000379621.1 RNA-binding protein KphA -
  R4712_RS01795 rpsP 362808..363080 (-) 273 WP_000268761.1 30S ribosomal protein S16 -
  R4712_RS01800 - 363250..363459 (+) 210 WP_000953865.1 hypothetical protein -
  R4712_RS01805 - 363938..364150 (+) 213 WP_000011696.1 hypothetical protein -
  R4712_RS01810 - 364234..365037 (+) 804 WP_044812314.1 peptidylprolyl isomerase -
  R4712_RS01815 - 365095..366636 (-) 1542 WP_000025400.1 ABC-F family ATP-binding cassette domain-containing protein -
  R4712_RS01820 - 366638..367120 (-) 483 WP_000976708.1 VanZ family protein -
  R4712_RS01825 rlmN 367120..368205 (-) 1086 WP_044812316.1 23S rRNA (adenine(2503)-C(2))-methyltransferase RlmN -
  R4712_RS01830 - 368226..368756 (-) 531 WP_001224352.1 YutD family protein -
  R4712_RS01835 sodA 368912..369517 (-) 606 WP_000974746.1 superoxide dismutase SodA -
  R4712_RS01840 holA 369690..370727 (-) 1038 WP_000879653.1 DNA polymerase III subunit delta -
  R4712_RS01845 - 370761..371696 (-) 936 WP_000255160.1 dihydroorotate oxidase -
  R4712_RS01850 metK 372249..373439 (-) 1191 WP_000003935.1 methionine adenosyltransferase -
  R4712_RS01855 - 373654..374997 (-) 1344 WP_000011000.1 DEAD/DEAH box helicase -
  R4712_RS01860 - 375137..375952 (-) 816 WP_000670836.1 endonuclease/exonuclease/phosphatase family protein -
  R4712_RS01865 - 376004..378184 (-) 2181 WP_078102885.1 PTS transporter subunit IIBC -
  R4712_RS01870 ftsX 378470..379396 (-) 927 WP_044812318.1 permease-like cell division protein FtsX -
  R4712_RS01875 ftsE 379389..380081 (-) 693 WP_000022268.1 cell division ATP-binding protein FtsE -
  R4712_RS01885 - 381302..381958 (-) 657 WP_000268677.1 CBS domain-containing protein -
  R4712_RS01890 - 382266..382976 (-) 711 WP_000062219.1 ABC transporter ATP-binding protein -
  R4712_RS01895 - 382976..383740 (-) 765 WP_000173398.1 ABC transporter ATP-binding protein -
  R4712_RS01900 - 383740..384696 (-) 957 WP_000662294.1 branched-chain amino acid ABC transporter permease -
  R4712_RS01905 - 384700..385569 (-) 870 WP_000941431.1 branched-chain amino acid ABC transporter permease -
  R4712_RS01910 - 385837..386997 (-) 1161 WP_000726149.1 ABC transporter substrate-binding protein -
  R4712_RS01915 - 387098..387346 (-) 249 WP_000462126.1 YlbG family protein -
  R4712_RS01920 clpP 387425..388015 (-) 591 WP_000613477.1 ATP-dependent Clp protease proteolytic subunit ClpP Regulator
  R4712_RS01925 upp 388189..388818 (-) 630 WP_000515974.1 uracil phosphoribosyltransferase -
  R4712_RS01930 - 388907..389374 (-) 468 WP_000136976.1 cytidine/deoxycytidylate deaminase family protein -
  R4712_RS01935 - 389393..389950 (-) 558 WP_000004139.1 TetR/AcrR family transcriptional regulator -
  R4712_RS01940 - 390075..390920 (+) 846 WP_000219939.1 DegV family protein -
  R4712_RS01945 - 390979..392151 (+) 1173 WP_044812324.1 NAD(P)/FAD-dependent oxidoreductase -
  R4712_RS01950 - 392202..392393 (+) 192 Protein_386 DUF1697 domain-containing protein -

Sequence

Protein


Download         Length: 196 a.a.        Molecular weight: 21358.36 Da        Isoelectric Point: 4.4910

>NTDB_id=895843 R4712_RS01920 WP_000613477.1 387425..388015(-) (clpP) [Streptococcus pneumoniae strain 16H2041]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTVIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRNTLEKILAENSGQ
SMEKVHADAERDNWMSAQETLEYGFIDEIMANNSLN

Nucleotide


Download         Length: 591 bp        

>NTDB_id=895843 R4712_RS01920 WP_000613477.1 387425..388015(-) (clpP) [Streptococcus pneumoniae strain 16H2041]
ATGATTCCTGTAGTTATTGAACAAACAAGCCGTGGAGAACGTTCTTACGATATTTACTCACGTCTTCTCAAAGACCGCAT
CATTATGCTGACAGGTCCGGTTGAAGACAATATGGCTAACTCTGTTATTGCCCAATTGCTTTTCTTGGATGCCCAAGATA
GTACGAAAGATATTTACCTTTATGTCAATACACCAGGTGGTTCTGTTTCAGCTGGTTTGGCAATCGTAGATACCATGAAC
TTTATCAAGGCAGATGTCCAAACCATTGTTATGGGAATGGCTGCATCTATGGGGACTGTCATCGCATCAAGTGGGGCAAA
AGGCAAACGTTTCATGCTTCCAAATGCTGAATACATGATTCACCAACCAATGGGCGGTACAGGTGGTGGTACCCAACAAA
CTGATATGGCTATCGCTGCAGAACACTTGCTCAAAACTCGTAATACCTTGGAAAAAATCTTGGCTGAAAATTCAGGTCAG
TCAATGGAAAAAGTCCATGCAGATGCAGAACGTGATAACTGGATGAGCGCCCAGGAAACACTTGAATATGGCTTTATTGA
TGAAATTATGGCCAACAATTCATTGAACTAA

Domains

Predicted by InterproScan.

Clp protease (CLP_protease)

(11-192)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  AlphaFold DB A0A064BX72

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pneumoniae Rx1

100

100

1
  clpP Streptococcus pneumoniae D39

100

100

1
  clpP Streptococcus pneumoniae R6

100

100

1
  clpP Streptococcus pneumoniae TIGR4

100

100

1
  clpP Streptococcus thermophilus LMG 18311

92.821

99.49

0.923
  clpP Streptococcus thermophilus LMD-9

92.821

99.49

0.923
  clpP Streptococcus pyogenes JRS4

90.769

99.49

0.903
  clpP Streptococcus pyogenes MGAS315

90.769

99.49

0.903
  clpP Streptococcus mutans UA159

85.714

100

0.857
  clpP Lactococcus lactis subsp. lactis strain DGCC12653

85.128

99.49

0.847
  clpP Lactococcus lactis subsp. cremoris KW2

84.615

99.49

0.842
  clpP Bacillus subtilis subsp. subtilis str. 168

58.854

97.959

0.577
  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.031

98.469

0.571