Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   R4712_RS00930 Genome accession   NZ_CP137110
Coordinates   195233..195883 (-) Length   216 a.a.
NCBI ID   WP_044791158.1    Uniprot ID   A0A9P1Q403
Organism   Streptococcus pneumoniae strain 16H2041     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 190233..200883
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4712_RS00910 - 190835..192019 (-) 1185 WP_000655949.1 ABC transporter permease -
  R4712_RS00915 - 192023..192610 (-) 588 WP_000933542.1 ATP-binding cassette domain-containing protein -
  R4712_RS00920 - 192642..192830 (-) 189 WP_023396236.1 hypothetical protein -
  R4712_RS00925 comEC/celB 193009..195249 (-) 2241 WP_050080727.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  R4712_RS00930 comEA/celA/cilE 195233..195883 (-) 651 WP_044791158.1 ComEA family DNA-binding protein Machinery gene
  R4712_RS00935 - 195951..196520 (-) 570 WP_044791155.1 GNAT family N-acetyltransferase -
  R4712_RS00940 ald 196697..197808 (+) 1112 Protein_187 alanine dehydrogenase -
  R4712_RS00945 - 198109..198435 (-) 327 Protein_188 TfoX/Sxy family protein -
  R4712_RS00950 - 198438..198938 (-) 501 WP_044812626.1 GNAT family N-acetyltransferase -
  R4712_RS00955 - 199131..200099 (-) 969 WP_000658183.1 PhoH family protein -
  R4712_RS00960 - 200185..200400 (-) 216 WP_001232085.1 YozE family protein -

Sequence

Protein


Download         Length: 216 a.a.        Molecular weight: 23217.60 Da        Isoelectric Point: 5.5171

>NTDB_id=895838 R4712_RS00930 WP_044791158.1 195233..195883(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain 16H2041]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQVEVAAVSKDLVSEKEVNKEEKEEPVEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSISKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide


Download         Length: 651 bp        

>NTDB_id=895838 R4712_RS00930 WP_044791158.1 195233..195883(-) (comEA/celA/cilE) [Streptococcus pneumoniae strain 16H2041]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTAAAGGAAACGAATTTGCAGGTTGAAGTTGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCAGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAATAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

SLBB domain (SLBB)

(76-126)

Helix-hairpin-helix motif (HHH_3)

(151-214)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae Rx1

98.611

100

0.986
  comEA/celA/cilE Streptococcus pneumoniae D39

98.611

100

0.986
  comEA/celA/cilE Streptococcus pneumoniae R6

98.611

100

0.986
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

96.759

100

0.968
  comEA/celA/cilE Streptococcus mitis NCTC 12261

95.37

100

0.954
  comEA/celA/cilE Streptococcus mitis SK321

90.741

100

0.907
  comEA Lactococcus lactis subsp. cremoris KW2

43.612

100

0.458
  comEA Bacillus subtilis subsp. subtilis str. 168

41.579

87.963

0.366
  comEA Latilactobacillus sakei subsp. sakei 23K

33.476

100

0.361