Detailed information NTG0895536

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: R4702_RS02680
• Genome accession: NZ_CP137106
• Coordinates: 536731..537318 (+)
• Length: 195 a.a.
• NCBI ID: WP_000205166.1
• Uniprot ID: Q9ETN5
• Organism: Streptococcus pneumoniae strain 16P4028
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 531731..542318

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4702_RS02635	blpZ	531864..532112 (-)	249	WP_000276506.1	immunity protein BlpZ	-
R4702_RS02640	-	532154..532843 (-)	690	WP_033705505.1	CPBP family intramembrane glutamic endopeptidase	-
R4702_RS02645	-	532875..533108 (-)	234	WP_033705506.1	bacteriocin class II family protein	-
R4702_RS02650	-	533355..534324 (-)	970	Protein_528	thioredoxin domain-containing protein	-
R4702_RS02655	-	534485..534856 (-)	372	WP_033705507.1	hypothetical protein	-
R4702_RS02660	-	535324..535443 (-)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
R4702_RS10965	-	535446..535511 (-)	66	Protein_531	ComC/BlpC family peptide pheromone/bacteriocin	-
R4702_RS02665	cipB	535547..535696 (-)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
R4702_RS02670	blpN	535940..536143 (-)	204	WP_001099490.1	two-peptide bacteriocin subunit BlpN	-
R4702_RS02675	blpM	536159..536413 (-)	255	WP_317810210.1	two-peptide bacteriocin subunit BlpM	-
R4702_RS02680	comA/nlmT	536731..537318 (+)	588	WP_000205166.1	cysteine peptidase family C39 domain-containing protein	Regulator
R4702_RS02685	comA/nlmT	537245..538888 (+)	1644	WP_078138292.1	peptide cleavage/export ABC transporter	Regulator
R4702_RS02690	-	538899..540260 (+)	1362	WP_024478409.1	bacteriocin secretion accessory protein	-
R4702_RS02695	blpC	540317..540472 (+)	156	WP_000358817.1	quorum-sensing system pheromone BlpC	-
R4702_RS02700	-	540514..541854 (-)	1341	WP_001017624.1	sensor histidine kinase	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22270.71 Da
• Isoelectric Point: 9.6188

>NTDB_id=895536 R4702_RS02680 WP_000205166.1 536731..537318(+) (comA/nlmT) [Streptococcus pneumoniae strain 16P4028]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKLQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=895536 R4702_RS02680 WP_000205166.1 536731..537318(+) (comA/nlmT) [Streptococcus pneumoniae strain 16P4028]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAACTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: Q9ETN5

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.89	93.333	0.559
comA	Streptococcus mitis NCTC 12261	54.891	94.359	0.518
comA	Streptococcus mitis SK321	54.348	94.359	0.513
comA	Streptococcus pneumoniae TIGR4	53.804	94.359	0.508
comA	Streptococcus pneumoniae Rx1	53.804	94.359	0.508
comA	Streptococcus pneumoniae D39	53.804	94.359	0.508
comA	Streptococcus pneumoniae R6	53.804	94.359	0.508
comA	Streptococcus gordonii str. Challis substr. CH1	52.717	94.359	0.497