Detailed information    

insolico Bioinformatically predicted

Overview

Name   comC/comC1   Type   Regulator
Locus tag   R4699_RS09245 Genome accession   NZ_CP137105
Coordinates   1831643..1831768 (+) Length   41 a.a.
NCBI ID   WP_000799689.1    Uniprot ID   P60242
Organism   Streptococcus pneumoniae strain 16H2092     
Function   binding to ComD; induce autophosphorylation of ComD (predicted from homology)   
Competence regulation

Genomic Context

Location: 1826643..1836768
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4699_RS09220 dnaA 1827128..1828489 (-) 1362 WP_000660615.1 chromosomal replication initiator protein DnaA -
  R4699_RS09225 spo0J 1828702..1829460 (-) 759 WP_050087436.1 ParB/RepB/Spo0J family partition protein Regulator
  R4699_RS09230 htrA 1829518..1830699 (-) 1182 WP_000681597.1 S1C family serine protease Regulator
  R4699_RS09235 rlmH 1830882..1831361 (+) 480 WP_000695929.1 23S rRNA (pseudouridine(1915)-N(3))-methyltransferase RlmH -
  R4699_RS09245 comC/comC1 1831643..1831768 (+) 126 WP_000799689.1 competence-stimulating peptide ComC Regulator
  R4699_RS09250 comD 1831789..1833113 (+) 1325 Protein_1811 competence system sensor histidine kinase ComD -
  R4699_RS09255 comE 1833110..1833862 (+) 753 WP_000866065.1 competence system response regulator transcription factor ComE Regulator
  R4699_RS09270 - 1834105..1834647 (-) 543 WP_001158266.1 TetR/AcrR family transcriptional regulator -
  R4699_RS09275 - 1834775..1836428 (+) 1654 Protein_1814 YhgE/Pip family protein -

Sequence

Protein


Download         Length: 41 a.a.        Molecular weight: 4971.00 Da        Isoelectric Point: 11.0775

>NTDB_id=895502 R4699_RS09245 WP_000799689.1 1831643..1831768(+) (comC/comC1) [Streptococcus pneumoniae strain 16H2092]
MKNTVKLEQFVALKEKDLQKIKGGEMRLSKFFRDFILQRKK

Nucleotide


Download         Length: 126 bp        

>NTDB_id=895502 R4699_RS09245 WP_000799689.1 1831643..1831768(+) (comC/comC1) [Streptococcus pneumoniae strain 16H2092]
ATGAAAAACACAGTTAAATTGGAACAGTTTGTAGCTTTGAAGGAAAAAGACTTACAAAAGATTAAAGGTGGGGAGATGAG
GTTGTCAAAATTCTTCCGTGATTTTATTTTACAAAGAAAAAAGTAA

Domains

Predicted by InterproScan.

COMC family (ComC)

(1-31)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 6CJ8
  PDB 6COO
  PDB 6COP
  PDB 6COQ
  PDB 6COR
  PDB 6COS
  PDB 6COW
  PDB 6OBW
  PDB 6OC2
  PDB 6OC4
  PDB 6OLD
  PDB 6V1N

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comC/comC1 Streptococcus pneumoniae R6

100

100

1
  comC/comC1 Streptococcus pneumoniae G54

100

100

1
  comC/comC1 Streptococcus pneumoniae D39

100

100

1
  comC/comC1 Streptococcus pneumoniae Rx1

100

100

1
  comC/comC2 Streptococcus pneumoniae A66

80.488

100

0.805
  comC/comC2 Streptococcus pneumoniae TIGR4

80.488

100

0.805
  comC Streptococcus mitis SK321

78.049

100

0.78
  comC Streptococcus mitis NCTC 12261

74.074

65.854

0.488
  comC/blpC Streptococcus mutans UA159

44.444

87.805

0.39