Detailed information    

insolico Bioinformatically predicted

Overview

Name   micA   Type   Regulator
Locus tag   R4699_RS03505 Genome accession   NZ_CP137105
Coordinates   689832..690536 (+) Length   234 a.a.
NCBI ID   WP_000722076.1    Uniprot ID   Q9S1K0
Organism   Streptococcus pneumoniae strain 16H2092     
Function   repress competence development (predicted from homology)   
Competence regulation

Genomic Context

Location: 684832..695536
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4699_RS03480 coaC 685121..685672 (-) 552 WP_001284128.1 phosphopantothenoylcysteine decarboxylase -
  R4699_RS03485 coaB 685684..686373 (-) 690 WP_000699495.1 phosphopantothenate--cysteine ligase -
  R4699_RS03490 - 686603..688273 (+) 1671 WP_000845292.1 formate--tetrahydrofolate ligase -
  R4699_RS03495 - 688379..688504 (-) 126 WP_001818232.1 hypothetical protein -
  R4699_RS03500 mutY 688601..689776 (+) 1176 WP_000886152.1 A/G-specific adenine glycosylase -
  R4699_RS03505 micA 689832..690536 (+) 705 WP_000722076.1 response regulator YycF Regulator
  R4699_RS03510 micB 690529..691878 (+) 1350 WP_050104987.1 cell wall metabolism sensor histidine kinase VicK Regulator
  R4699_RS03515 vicX 691880..692689 (+) 810 WP_001289493.1 MBL fold metallo-hydrolase Regulator
  R4699_RS03520 relB 692780..693022 (+) 243 WP_024477795.1 type II toxin-antitoxin system RelB family antitoxin -
  R4699_RS03525 - 693024..693278 (+) 255 WP_001809704.1 type II toxin-antitoxin system RelE/ParE family toxin -
  R4699_RS03530 - 693325..694098 (+) 774 WP_050104986.1 potassium channel family protein -
  R4699_RS03535 - 694361..695347 (-) 987 WP_000204727.1 L-lactate dehydrogenase -

Sequence

Protein


Download         Length: 234 a.a.        Molecular weight: 26815.63 Da        Isoelectric Point: 4.7164

>NTDB_id=895474 R4699_RS03505 WP_000722076.1 689832..690536(+) (micA) [Streptococcus pneumoniae strain 16H2092]
MKKILIVDDEKPISDIIKFNMTKEGYEVVTAFNGREALEQFEAEQPDIIILDLMLPEIDGLEVAKTIRKTSSVPILMLSA
KDSEFDKVIGLELGADDYVTKPFSNRELQARVKALLRRSQPMPVDGQEADSKPQPIQIGDLEIVPDAYVAKKYGEELDLT
HREFELLYHLASHTGQVITREHLLETVWGYDYFGDVRTVDVTVRRLREKIEDTPSRPEYILTRRGVGYYMRNNA

Nucleotide


Download         Length: 705 bp        

>NTDB_id=895474 R4699_RS03505 WP_000722076.1 689832..690536(+) (micA) [Streptococcus pneumoniae strain 16H2092]
ATGAAAAAAATACTAATTGTAGATGATGAGAAACCAATCTCGGATATTATCAAGTTTAATATGACCAAGGAAGGTTACGA
AGTTGTAACTGCTTTTAATGGTCGTGAAGCGCTAGAGCAATTTGAAGCAGAGCAACCAGATATTATTATTCTGGATTTGA
TGCTTCCAGAAATTGATGGTTTAGAAGTTGCTAAGACCATTCGTAAGACAAGCAGTGTGCCCATTCTTATGCTTTCAGCC
AAAGATAGTGAATTTGATAAGGTTATCGGTTTGGAACTTGGGGCAGATGACTATGTAACGAAACCCTTCTCCAATCGTGA
GTTGCAGGCGCGTGTTAAAGCTCTTCTGCGTCGTTCTCAACCTATGCCAGTAGATGGTCAGGAAGCAGATAGTAAACCTC
AACCTATCCAAATTGGGGATTTAGAAATTGTTCCAGACGCCTACGTGGCTAAAAAATATGGCGAAGAACTAGACTTAACC
CATCGTGAATTTGAGCTTTTGTATCATTTAGCATCGCATACAGGTCAAGTCATCACGCGCGAACACTTGCTTGAGACTGT
CTGGGGTTATGACTATTTTGGTGATGTCCGTACAGTTGATGTGACTGTACGACGTCTGCGTGAGAAGATTGAAGATACGC
CCAGCCGACCAGAGTATATCTTGACGCGCCGTGGTGTAGGGTATTACATGAGAAATAATGCTTGA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(4-112)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(154-229)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure
  PDB 1NXS
  PDB 2A9O
  PDB 2A9P

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  micA Streptococcus pneumoniae Cp1015

100

100

1
  vicR Streptococcus mutans UA159

78.541

99.573

0.782
  covR Streptococcus salivarius strain HSISS4

44.156

98.718

0.436
  covR Lactococcus lactis subsp. lactis strain DGCC12653

43.478

98.291

0.427
  scnR Streptococcus mutans UA159

38.197

99.573

0.38