Detailed information NTG0895370

Bioinformatically predicted

Overview

• Name: dprA/cilB/dalA
• Type: Machinery gene
• Locus tag: R4713_RS10230
• Genome accession: NZ_CP137103
• Coordinates: 1961452..1962300 (+)
• Length: 282 a.a.
• NCBI ID: WP_000705301.1
• Uniprot ID: A0A0D6J8J8
• Organism: Streptococcus pneumoniae strain 21334
• Function: ssDNA binding; loading RecA onto ssDNA; competence shut-off (predicted from homology) DNA processing Competence regulation

Genomic Context

Location: 1956452..1967300

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4713_RS10205	-	1957167..1957874 (+)	708	WP_000638502.1	2-C-methyl-D-erythritol 4-phosphate cytidylyltransferase	-
R4713_RS10210	-	1957879..1958901 (+)	1023	WP_000609885.1	ribitol-5-phosphate dehydrogenase	-
R4713_RS10215	licA	1958918..1959787 (+)	870	WP_000411215.1	choline kinase LicA	-
R4713_RS10220	-	1959777..1960655 (+)	879	WP_000837618.1	DMT family transporter	-
R4713_RS10225	-	1960667..1961356 (+)	690	WP_000643970.1	sugar phosphate nucleotidyltransferase	-
R4713_RS10230	dprA/cilB/dalA	1961452..1962300 (+)	849	WP_000705301.1	DNA-processing protein DprA	Machinery gene
R4713_RS10235	-	1962483..1962605 (-)	123	WP_001814242.1	hypothetical protein	-
R4713_RS10240	-	1963182..1964225 (+)	1044	WP_001812883.1	TIGR00341 family protein	-
R4713_RS10245	topA	1964392..1966479 (+)	2088	WP_000179644.1	type I DNA topoisomerase	-
R4713_RS10250	-	1966585..1966944 (+)	360	WP_001237223.1	YbaN family protein	-

Sequence

Protein

• Length: 282 a.a.
• Molecular weight: 31034.67 Da
• Isoelectric Point: 5.4047

>NTDB_id=895370 R4713_RS10230 WP_000705301.1 1961452..1962300(+) (dprA/cilB/dalA) [Streptococcus pneumoniae strain 21334]
MKITNYEIYKLKKSGLTNQQILKVLEYGENVDQELLLGDIADISGCRNPAVFMERYFQIDDAHLSKEFQKFPSFSILDDC
YPWDLSEIYDAPVLLFYKGNLDLLKFPKVAVVGSRACSKQGAKSVEKVIQGLENELVIVSGLAKGIDTAAHMAALQNGGK
TIAVIGTGLDVFYPKANKRLQDYIGNDHLALSEYGPGEQPLKFHFPARNRIIAGLCRGVIVAEAKMRSGSLITCERAMEE
GRDVFAIPGSILDGLSDGCHHLIQEGAKLVTSGQDVLAEFEF

Nucleotide

• Length: 849 bp

>NTDB_id=895370 R4713_RS10230 WP_000705301.1 1961452..1962300(+) (dprA/cilB/dalA) [Streptococcus pneumoniae strain 21334]
ATGAAAATCACAAACTATGAAATCTATAAGTTAAAAAAATCAGGTTTGACCAATCAACAGATTTTGAAAGTGCTAGAATA
CGGTGAAAATGTTGATCAGGAGCTTTTGTTGGGTGATATTGCAGATATATCAGGTTGCCGTAATCCAGCCGTTTTTATGG
AACGTTATTTTCAGATAGACGATGCGCATTTGTCGAAAGAGTTTCAAAAATTTCCATCTTTCTCTATTTTAGATGACTGT
TATCCTTGGGATTTGAGTGAAATATATGATGCGCCTGTACTTTTATTTTACAAGGGAAATCTTGACCTCCTGAAATTCCC
GAAGGTAGCGGTCGTGGGCAGTCGTGCTTGTAGCAAACAGGGAGCTAAGTCAGTTGAAAAAGTCATTCAAGGCTTGGAAA
ATGAACTGGTTATTGTCAGTGGTCTGGCCAAGGGCATTGACACAGCAGCTCATATGGCAGCTCTTCAGAATGGCGGAAAA
ACCATTGCAGTGATTGGAACAGGACTGGATGTGTTTTATCCTAAAGCCAATAAACGCTTGCAAGACTACATCGGCAATGA
CCATCTGGCTCTAAGTGAATATGGACCTGGCGAACAACCTCTGAAATTTCATTTTCCTGCCCGTAATCGCATCATTGCTG
GACTTTGTCGTGGTGTGATTGTAGCAGAGGCTAAGATGCGTTCAGGTAGTCTCATTACCTGTGAGCGAGCAATGGAAGAA
GGACGCGATGTCTTTGCTATTCCTGGTAGCATTTTAGATGGACTATCAGACGGTTGCCATCATTTGATTCAAGAAGGAGC
AAAATTGGTCACCAGTGGGCAAGATGTTCTTGCGGAATTTGAATTTTAA

Domains

Predicted by InterproScan.

• DNA recombination-mediator protein A (DNA_processg_A) (75-271)

• DNA processing protein A sterile alpha motif domain (SAM_DprA) (3-64)

3D structure

• AlphaFold DB: A0A0D6J8J8

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
dprA/cilB/dalA	Streptococcus pneumoniae Rx1	99.645	100	0.996
dprA/cilB/dalA	Streptococcus pneumoniae D39	99.645	100	0.996
dprA/cilB/dalA	Streptococcus pneumoniae R6	99.645	100	0.996
dprA/cilB/dalA	Streptococcus pneumoniae TIGR4	99.645	100	0.996
dprA/cilB/dalA	Streptococcus mitis NCTC 12261	98.227	100	0.982
dprA/cilB/dalA	Streptococcus mitis SK321	97.518	100	0.975
dprA	Streptococcus mutans UA159	63.214	99.291	0.628
dprA	Lactococcus lactis subsp. cremoris KW2	55.357	99.291	0.55
dprA	Staphylococcus aureus N315	37.456	100	0.376
dprA	Haemophilus influenzae Rd KW20	38.202	94.681	0.362