Detailed information NTG0895209

Bioinformatically predicted

Overview

• Name: comA/nlmT
• Type: Regulator
• Locus tag: R4710_RS08405
• Genome accession: NZ_CP137101
• Coordinates: 1594305..1594892 (-)
• Length: 195 a.a.
• NCBI ID: WP_050245347.1
• Uniprot ID: A0A4J2BEZ2
• Organism: Streptococcus pneumoniae strain 16P2012-2
• Function: transport of ComC (predicted from homology) Competence regulation

Genomic Context

Location: 1589305..1599892

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
R4710_RS08385	-	1589767..1591107 (+)	1341	WP_317804516.1	sensor histidine kinase	-
R4710_RS08390	blpC	1591151..1591306 (-)	156	WP_000358811.1	quorum-sensing system pheromone BlpC	-
R4710_RS08395	-	1591363..1592724 (-)	1362	WP_001069064.1	bacteriocin secretion accessory protein	-
R4710_RS08400	comA/nlmT	1592735..1594411 (-)	1677	WP_306423909.1	peptide cleavage/export ABC transporter	Regulator
R4710_RS08405	comA/nlmT	1594305..1594892 (-)	588	WP_050245347.1	cysteine peptidase family C39 domain-containing protein	Regulator
R4710_RS08410	blpM	1595182..1595436 (+)	255	WP_050245346.1	two-peptide bacteriocin subunit BlpM	-
R4710_RS08415	blpN	1595452..1595655 (+)	204	WP_001099490.1	two-peptide bacteriocin subunit BlpN	-
R4710_RS08420	cipB	1595899..1596048 (+)	150	WP_001809846.1	bacteriocin-like peptide BlpO	Regulator
R4710_RS11280	-	1596084..1596149 (+)	66	Protein_1621	ComC/BlpC family peptide pheromone/bacteriocin	-
R4710_RS08425	-	1596152..1596271 (+)	120	WP_000346296.1	PncF family bacteriocin immunity protein	-
R4710_RS08430	-	1596739..1597110 (+)	372	WP_404969402.1	hypothetical protein	-
R4710_RS08435	-	1597271..1598240 (+)	970	Protein_1624	thioredoxin domain-containing protein	-
R4710_RS08440	-	1598487..1598720 (+)	234	WP_033705506.1	bacteriocin class II family protein	-
R4710_RS08445	-	1598752..1599441 (+)	690	WP_033705505.1	CPBP family intramembrane glutamic endopeptidase	-
R4710_RS08450	blpZ	1599483..1599731 (+)	249	WP_000276506.1	immunity protein BlpZ	-

Sequence

Protein

• Length: 195 a.a.
• Molecular weight: 22304.72 Da
• Isoelectric Point: 9.6188

>NTDB_id=895209 R4710_RS08405 WP_050245347.1 1594305..1594892(-) (comA/nlmT) [Streptococcus pneumoniae strain 16P2012-2]
MTSYKRTFVPQIDARDCGVAALASIAKFYGSDFSLAHLRELAKTNKEGTTALGIVKAADEMGFETRPVQADKTLFDMSDV
PYPFIVHVNKEGKFQHYYVVYQTKKDYLIIGDPDPSVKITKMSKERFFYEWTGVAIFLATKPSYQPHKDKKNGLLSKLPS
SDFQTKISHCLHCSLKLIGHYYQYRWFLLSPRNLG

Nucleotide

• Length: 588 bp

>NTDB_id=895209 R4710_RS08405 WP_050245347.1 1594305..1594892(-) (comA/nlmT) [Streptococcus pneumoniae strain 16P2012-2]
ATGACTTCTTATAAACGTACATTTGTTCCTCAAATAGATGCGAGAGACTGTGGTGTCGCTGCCTTAGCCTCGATTGCTAA
ATTCTATGGTTCAGATTTTTCTCTAGCTCACTTGAGAGAACTTGCAAAGACCAATAAAGAAGGGACGACTGCTCTTGGCA
TTGTAAAAGCCGCTGATGAAATGGGCTTTGAAACAAGACCTGTTCAAGCAGATAAAACGCTCTTTGACATGAGTGATGTC
CCCTATCCATTTATCGTTCACGTTAACAAAGAAGGAAAATTCCAACATTACTATGTTGTCTATCAAACAAAGAAAGACTA
TCTGATTATTGGTGATCCTGACCCTTCTGTAAAAATCACTAAAATGTCAAAAGAACGCTTTTTCTATGAATGGACTGGAG
TAGCTATTTTTCTAGCTACCAAACCCAGCTATCAACCCCATAAAGATAAAAAGAATGGTCTACTAAGCAAGCTTCCTTCC
TCTGATTTTCAAACAAAAATCTCTCATTGCTTACATTGTTCTCTCAAGCTTATTGGTCACTATTATCAATATAGGTGGTT
CTTACTATCTCCAAGGAATCTTGGATGA

Domains

Predicted by InterproScan.

• Peptidase C39 family (Peptidase_C39) (7-142)

3D structure

• AlphaFold DB: A0A4J2BEZ2

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
comA/nlmT	Streptococcus mutans UA159	59.341	93.333	0.554
comA	Streptococcus mitis NCTC 12261	54.348	94.359	0.513
comA	Streptococcus mitis SK321	53.804	94.359	0.508
comA	Streptococcus pneumoniae TIGR4	53.261	94.359	0.503
comA	Streptococcus pneumoniae Rx1	53.261	94.359	0.503
comA	Streptococcus pneumoniae D39	53.261	94.359	0.503
comA	Streptococcus pneumoniae R6	53.261	94.359	0.503
comA	Streptococcus gordonii str. Challis substr. CH1	52.174	94.359	0.492