Detailed information    

insolico Bioinformatically predicted

Overview

Name   comEA/celA/cilE   Type   Machinery gene
Locus tag   R4703_RS10615 Genome accession   NZ_CP137100
Coordinates   1982382..1983032 (+) Length   216 a.a.
NCBI ID   WP_001864147.1    Uniprot ID   -
Organism   Streptococcus pneumoniae strain LYP     
Function   dsDNA binding to the cell surface (predicted from homology)   
DNA binding and uptake

Genomic Context

Location: 1977382..1988032
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R4703_RS10585 pyrH 1978106..1978843 (+) 738 WP_000002997.1 UMP kinase -
  R4703_RS10590 frr 1978852..1979409 (+) 558 WP_050200983.1 ribosome recycling factor -
  R4703_RS10595 cvfB 1979469..1980323 (+) 855 WP_001095445.1 RNA-binding virulence regulatory protein CvfB -
  R4703_RS10600 - 1980332..1980547 (+) 216 WP_001232082.1 YozE family protein -
  R4703_RS10605 - 1980633..1981637 (+) 1005 WP_050096410.1 PhoH family protein -
  R4703_RS10610 - 1981745..1982314 (+) 570 WP_001864145.1 GNAT family N-acetyltransferase -
  R4703_RS10615 comEA/celA/cilE 1982382..1983032 (+) 651 WP_001864147.1 helix-hairpin-helix domain-containing protein Machinery gene
  R4703_RS10620 comEC/celB 1983016..1985256 (+) 2241 WP_023396235.1 DNA internalization-related competence protein ComEC/Rec2 Machinery gene
  R4703_RS10625 - 1985435..1985623 (+) 189 WP_023396236.1 hypothetical protein -
  R4703_RS10630 - 1985655..1986242 (+) 588 WP_000933542.1 ATP-binding cassette domain-containing protein -
  R4703_RS10635 - 1986246..1987427 (+) 1182 WP_000655945.1 hypothetical protein -

Sequence

Protein


Download         Length: 216 a.a.        Molecular weight: 23205.54 Da        Isoelectric Point: 5.5171

>NTDB_id=895140 R4703_RS10615 WP_001864147.1 1982382..1983032(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain LYP]
MEAIIEKIKEYKIIVICTGLGLLVGGFFLLKPAPQTPVKETNLQVEVAAVSKDLVSEKEVNKEEKEEPVEQDLITVDVKG
AVKSPGIYDLPVGSRVNDAVQKAGGLTEQADSKSLNLAQKVSDEALVYVPTKGEEAVSQQTGSGTASSTSKEKKVNLNKA
SLEELKQVKGLGGKRAQDIIDHREANGKFKSVDELKKVSGIGGKTIEKLKDYVTVD

Nucleotide


Download         Length: 651 bp        

>NTDB_id=895140 R4703_RS10615 WP_001864147.1 1982382..1983032(+) (comEA/celA/cilE) [Streptococcus pneumoniae strain LYP]
ATGGAAGCAATTATCGAGAAAATCAAAGAGTATAAAATCATCGTCATCTGTACTGGTCTGGGCTTGCTTGTAGGCGGATT
TTTCCTGCTAAAGCCAGCTCCACAAACACCTGTCAAAGAAACGAATTTGCAGGTTGAAGTTGCAGCTGTTTCCAAGGATT
TGGTATCCGAAAAGGAAGTGAACAAGGAAGAGAAGGAAGAACCAGTTGAACAAGATCTAATCACAGTAGATGTCAAAGGT
GCTGTCAAATCGCCAGGGATTTATGACTTGCCTGTAGGTAGTCGAGTCAATGATGCTGTTCAGAAGGCTGGTGGCTTGAC
AGAGCAAGCAGACAGCAAGTCGCTCAATCTAGCTCAGAAAGTTAGTGATGAGGCTCTGGTTTACGTTCCTACTAAGGGAG
AAGAAGCAGTTAGTCAACAGACTGGTTCGGGGACAGCTTCTTCAACAAGCAAGGAAAAGAAGGTCAATCTCAACAAGGCC
AGTCTGGAAGAACTCAAGCAGGTCAAGGGACTGGGAGGAAAACGAGCTCAGGACATTATCGACCATCGTGAGGCAAATGG
CAAGTTCAAGTCAGTAGACGAGCTCAAGAAGGTCTCTGGCATTGGTGGCAAAACAATAGAAAAGCTTAAAGACTATGTTA
CAGTGGATTAA

Domains

Predicted by InterproScan.

Helix-hairpin-helix motif (HHH_3)

(151-214)

SLBB domain (SLBB)

(76-126)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  comEA/celA/cilE Streptococcus pneumoniae Rx1

98.148

100

0.981
  comEA/celA/cilE Streptococcus pneumoniae D39

98.148

100

0.981
  comEA/celA/cilE Streptococcus pneumoniae R6

98.148

100

0.981
  comEA/celA/cilE Streptococcus pneumoniae TIGR4

97.222

100

0.972
  comEA/celA/cilE Streptococcus mitis NCTC 12261

95.833

100

0.958
  comEA/celA/cilE Streptococcus mitis SK321

91.204

100

0.912
  comEA Lactococcus lactis subsp. cremoris KW2

43.612

100

0.458
  comEA Latilactobacillus sakei subsp. sakei 23K

33.906

100

0.366
  comEA Bacillus subtilis subsp. subtilis str. 168

41.579

87.963

0.366