Detailed information    

insolico Bioinformatically predicted

Overview

Name   covR   Type   Regulator
Locus tag   R3H37_RS07665 Genome accession   NZ_CP136948
Coordinates   1544821..1545507 (-) Length   228 a.a.
NCBI ID   WP_002991052.1    Uniprot ID   -
Organism   Streptococcus pyogenes strain Spyo01     
Function   repress comR expression (predicted from homology)   
Competence regulation

Genomic Context

Location: 1539821..1550507
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  R3H37_RS07645 (R3H37_07650) dnaI 1540542..1541444 (-) 903 WP_032464819.1 primosomal protein DnaI -
  R3H37_RS07650 (R3H37_07655) - 1541445..1542620 (-) 1176 WP_129284398.1 replication initiation and membrane attachment family protein -
  R3H37_RS07655 (R3H37_07660) nrdR 1542604..1543098 (-) 495 WP_002985941.1 transcriptional regulator NrdR -
  R3H37_RS07660 (R3H37_07665) covS 1543313..1544815 (-) 1503 WP_129284399.1 two-component system sensor histidine kinase CovS -
  R3H37_RS07665 (R3H37_07670) covR 1544821..1545507 (-) 687 WP_002991052.1 two-component system response regulator CovR Regulator
  R3H37_RS07670 (R3H37_07675) - 1545774..1546307 (-) 534 WP_011054200.1 YceD family protein -
  R3H37_RS07675 (R3H37_07680) htpX 1546541..1547437 (-) 897 WP_014407315.1 zinc metalloprotease HtpX -
  R3H37_RS07680 (R3H37_07685) - 1547484..1548041 (-) 558 WP_002985956.1 LemA family protein -
  R3H37_RS07685 (R3H37_07690) rsmG 1548191..1548904 (+) 714 WP_129284400.1 16S rRNA (guanine(527)-N(7))-methyltransferase RsmG -
  R3H37_RS07690 (R3H37_07695) ktrB 1548988..1550364 (+) 1377 WP_032459855.1 potassium uptake transporter channel subunit KtrB -

Sequence

Protein


Download         Length: 228 a.a.        Molecular weight: 26618.70 Da        Isoelectric Point: 4.6586

>NTDB_id=893622 R3H37_RS07665 WP_002991052.1 1544821..1545507(-) (covR) [Streptococcus pyogenes strain Spyo01]
MTKKILIIEDEKNLARFVSLELQHEGYEVIVEVNGREGLETALEKEFDLILLDLMLPEMDGFEVTRRLQTEKTTYIMMMT
ARDSIMDVVAGLDRGADDYIVKPFAIEELLARIRAIFRRQDIESEKKVPSQGIYRDLVLNPQNRSVNRGDDEISLTKREY
DLLNILMTNMNRVMTREELLSNVWKYDEAVETNVVDVYIRYLRGKIDIPGKESYIQTVRGMGYVIREK

Nucleotide


Download         Length: 687 bp        

>NTDB_id=893622 R3H37_RS07665 WP_002991052.1 1544821..1545507(-) (covR) [Streptococcus pyogenes strain Spyo01]
ATGACAAAGAAAATTTTAATTATTGAAGATGAAAAGAATCTGGCTAGATTCGTTTCTCTTGAGCTGCAACATGAGGGTTA
TGAAGTCATTGTTGAGGTCAATGGTCGCGAAGGGTTAGAAACTGCTTTGGAAAAAGAGTTTGATTTAATCCTGCTTGACT
TAATGTTACCAGAGATGGATGGTTTTGAAGTGACCCGTCGTTTGCAAACCGAAAAAACAACATATATCATGATGATGACT
GCGCGTGATTCTATTATGGATGTGGTTGCAGGTTTAGACCGCGGTGCAGACGACTATATTGTTAAACCGTTTGCCATTGA
AGAACTACTTGCCCGTATTCGTGCTATTTTCCGCCGTCAAGATATTGAATCTGAGAAGAAAGTGCCTAGTCAAGGTATTT
ATCGAGATCTAGTTTTAAATCCACAAAACCGTTCAGTTAATCGTGGCGACGATGAGATTTCTCTCACTAAACGTGAATAT
GATTTGCTTAATATTTTGATGACTAACATGAATCGTGTCATGACACGTGAAGAATTATTGTCAAATGTTTGGAAATATGA
TGAAGCCGTTGAGACTAATGTTGTAGATGTCTATATTCGTTATCTCCGCGGCAAAATTGACATTCCAGGCAAGGAATCTT
ATATCCAAACAGTGCGTGGCATGGGATACGTTATTCGTGAGAAATAA

Domains

Predicted by InterproScan.

Response regulator receiver domain (Response_reg)

(5-114)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(151-224)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  covR Streptococcus salivarius strain HSISS4

82.096

100

0.825
  covR Lactococcus lactis subsp. lactis strain DGCC12653

66.96

99.561

0.667
  vicR Streptococcus mutans UA159

43.966

100

0.447
  micA Streptococcus pneumoniae Cp1015

42.174

100

0.425