Detailed information    

insolico Bioinformatically predicted

Overview

Name   ciaR   Type   Regulator
Locus tag   AAEU35_RS11005 Genome accession   NZ_CP152294
Coordinates   2172651..2173319 (+) Length   222 a.a.
NCBI ID   WP_021722129.1    Uniprot ID   -
Organism   Lactococcus lactis strain Q13     
Function   repress competence development; post-transcriptional repression of CSP production (predicted from homology)   
Competence regulation

Genomic Context

Location: 2167651..2178319
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  AAEU35_RS10995 - 2169091..2171346 (+) 2256 WP_012898269.1 glycoside hydrolase family 65 protein -
  AAEU35_RS11000 - 2171499..2172473 (+) 975 WP_058206283.1 LacI family DNA-binding transcriptional regulator -
  AAEU35_RS11005 ciaR 2172651..2173319 (+) 669 WP_021722129.1 response regulator transcription factor Regulator
  AAEU35_RS11010 ciaH 2173412..2174782 (+) 1371 WP_003130363.1 HAMP domain-containing sensor histidine kinase Regulator
  AAEU35_RS11015 - 2174930..2176672 (+) 1743 WP_012898266.1 1-deoxy-D-xylulose-5-phosphate synthase -
  AAEU35_RS11020 yidD 2176789..2177055 (+) 267 WP_012898265.1 membrane protein insertion efficiency factor YidD -

Sequence

Protein


Download         Length: 222 a.a.        Molecular weight: 25516.42 Da        Isoelectric Point: 4.4864

>NTDB_id=891859 AAEU35_RS11005 WP_021722129.1 2172651..2173319(+) (ciaR) [Lactococcus lactis strain Q13]
MIKILLVEDDLSLSKSVYDFLKSFAQVKQVYDGVEGLYEAELGIYDLILLDLMLPEKNGFEVLKELREQNVDTPVLIMTA
KESLDDKMHGFDIGADDYLTKPFYLDELKARIQALLKRTGKLEDSNGLTYGNIRLNLSNKSTLVDDQPVDLIGKEFDLVV
YLMQNQNVILPKEQIFDRIWGYDSDTTVTVVEVYMSKIRKKLKDTEFVNNLSTLRNVGYILR

Nucleotide


Download         Length: 669 bp        

>NTDB_id=891859 AAEU35_RS11005 WP_021722129.1 2172651..2173319(+) (ciaR) [Lactococcus lactis strain Q13]
ATGATTAAAATTTTATTAGTGGAGGATGATTTATCACTCTCAAAATCTGTTTACGATTTCTTAAAATCATTTGCGCAAGT
CAAACAGGTTTATGATGGAGTTGAAGGACTCTATGAGGCAGAATTGGGAATTTATGATTTAATTTTGCTTGATTTAATGC
TTCCAGAAAAGAATGGTTTTGAAGTCTTAAAGGAATTACGTGAGCAAAATGTAGATACGCCAGTCTTAATCATGACTGCT
AAGGAATCTTTGGATGATAAAATGCATGGATTCGACATTGGAGCAGATGATTATTTAACAAAACCTTTCTATTTAGATGA
ACTAAAAGCACGTATTCAAGCACTTTTGAAACGGACAGGTAAATTAGAAGATTCAAACGGTTTAACTTATGGAAATATTC
GTTTGAATTTATCAAATAAATCAACTTTAGTTGATGATCAACCTGTTGATTTAATCGGAAAAGAATTTGATTTAGTCGTT
TATTTAATGCAAAATCAAAATGTTATTTTGCCAAAAGAGCAAATTTTTGACCGGATTTGGGGCTATGACAGTGATACAAC
AGTAACTGTTGTTGAAGTTTATATGAGTAAAATTCGGAAAAAATTGAAAGATACAGAATTTGTCAATAATCTTTCAACCT
TGCGAAATGTTGGCTATATCTTGAGATAA

Domains

Predicted by InterProScan.

Response regulator receiver domain (Response_reg)

(4-113)

Transcriptional regulatory protein, C terminal (Trans_reg_C)

(146-221)


Secondary structure

Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure

Source ID Structure

Transmembrane helices

Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.


Visualization of predicted probability:


Similar proteins

Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  ciaR Streptococcus pneumoniae Rx1

74.775

100

0.748
  ciaR Streptococcus pneumoniae D39

74.775

100

0.748
  ciaR Streptococcus pneumoniae R6

74.775

100

0.748
  ciaR Streptococcus pneumoniae TIGR4

74.775

100

0.748
  ciaR Streptococcus mutans UA159

72.973

100

0.73
  covR Lactococcus lactis subsp. lactis strain DGCC12653

38.667

100

0.392
  covR Streptococcus salivarius strain HSISS4

37.333

100

0.378
  vicR Streptococcus mutans UA159

34.764

100

0.365
  micA Streptococcus pneumoniae Cp1015

34.483

100

0.36