Detailed information NTG0887040

Bioinformatically predicted

Overview

• Name: micA
• Type: Regulator
• Locus tag: RSK81_RS08570
• Genome accession: NZ_CP135591
• Coordinates: 1741812..1742513 (-)
• Length: 233 a.a.
• NCBI ID: WP_002894937.1
• Uniprot ID: A0A0B7GM19
• Organism: Streptococcus sp. DTU_2020_1000888_1_SI_GRL_NUU_041A
• Function: repress competence development (predicted from homology) Competence regulation

Genomic Context

Location: 1736812..1747513

Locus tag	Gene name	Coordinates (strand)	Size (bp)	Protein ID	Product	Description
RSK81_RS08550 (RSK81_08550)	rnc	1738392..1739090 (-)	699	WP_002903151.1	ribonuclease III	-
RSK81_RS08555 (RSK81_08555)	-	1739212..1739571 (-)	360	WP_002906095.1	YbaN family protein	-
RSK81_RS08560 (RSK81_08560)	vicX	1739663..1740463 (-)	801	WP_002914756.1	MBL fold metallo-hydrolase	Regulator
RSK81_RS08565 (RSK81_08565)	micB	1740473..1741819 (-)	1347	WP_002894938.1	cell wall metabolism sensor histidine kinase VicK	Regulator
RSK81_RS08570 (RSK81_08570)	micA	1741812..1742513 (-)	702	WP_002894937.1	response regulator YycF	Regulator
RSK81_RS08575 (RSK81_08575)	-	1742854..1743615 (+)	762	WP_032913415.1	amino acid ABC transporter ATP-binding protein	-
RSK81_RS08580 (RSK81_08580)	-	1743630..1744442 (+)	813	WP_002906091.1	transporter substrate-binding domain-containing protein	-
RSK81_RS08585 (RSK81_08585)	-	1744455..1745135 (+)	681	WP_002906090.1	amino acid ABC transporter permease	-
RSK81_RS08590 (RSK81_08590)	-	1745146..1745805 (+)	660	WP_002912899.1	amino acid ABC transporter permease	-
RSK81_RS08595 (RSK81_08595)	-	1745914..1746312 (+)	399	WP_002897198.1	hypothetical protein	-
RSK81_RS08600 (RSK81_08600)	-	1746351..1746728 (-)	378	WP_002899930.1	carboxymuconolactone decarboxylase family protein	-
RSK81_RS08605 (RSK81_08605)	-	1746806..1747168 (+)	363	WP_049553289.1	MerR family transcriptional regulator	-

Sequence

Protein

• Length: 233 a.a.
• Molecular weight: 26735.63 Da
• Isoelectric Point: 4.7458

>NTDB_id=887040 RSK81_RS08570 WP_002894937.1 1741812..1742513(-) (micA) [Streptococcus sp. DTU_2020_1000888_1_SI_GRL_NUU_041A]
MKKILVVDDEKPISDIIKFNMAKEGYEVLTAFDGKEALEMFEAEQPDILILDLMLPEVDGLEVARTIRKTSNVPIIVLSA
KDSEFDKVIGLEIGADDYVTKPFSNRELQARVKALLRRADLVVENQVEESGPNELTIGELQILPDAFVAKKHGKELELTH
REFELLHHLATHIGQVMTREHLLETVWGYDYFGDVRTVDVTIRRLREKIEDTPSRPEYILTRRGVGYYMRNND

Nucleotide

• Length: 702 bp

>NTDB_id=887040 RSK81_RS08570 WP_002894937.1 1741812..1742513(-) (micA) [Streptococcus sp. DTU_2020_1000888_1_SI_GRL_NUU_041A]
ATGAAGAAAATATTAGTTGTAGATGATGAGAAGCCAATCTCAGATATTATTAAGTTTAATATGGCCAAGGAAGGCTATGA
GGTTTTGACTGCTTTTGATGGTAAGGAAGCCTTGGAAATGTTTGAAGCAGAACAGCCAGATATCTTGATTTTGGACTTGA
TGCTGCCAGAAGTGGATGGATTGGAAGTGGCTCGGACTATTCGTAAGACCAGCAATGTTCCGATTATTGTATTGTCTGCT
AAGGACAGTGAGTTTGACAAGGTTATCGGCCTTGAAATCGGTGCAGATGACTATGTGACTAAGCCTTTCTCAAATCGTGA
GCTGCAGGCGCGTGTCAAGGCACTTCTTCGTCGGGCAGACCTTGTTGTGGAAAACCAAGTAGAAGAAAGTGGCCCGAACG
AGCTGACCATTGGGGAACTGCAGATTTTGCCAGATGCTTTTGTTGCTAAGAAGCATGGCAAGGAGCTGGAGTTGACTCAC
CGCGAGTTTGAATTGCTTCACCATTTGGCGACACATATCGGTCAGGTGATGACACGTGAGCACTTGCTGGAAACAGTATG
GGGCTATGACTATTTTGGCGATGTCCGTACAGTGGATGTGACCATTCGCCGCCTGCGTGAAAAGATTGAAGATACGCCAA
GCCGACCTGAGTATATCTTGACTCGCCGCGGAGTTGGCTATTATATGAGAAATAATGATTGA

Domains

Predicted by InterproScan.

• Transcriptional regulatory protein, C terminal (Trans_reg_C) (153-228)

• Response regulator receiver domain (Response_reg) (4-112)

3D structure

• AlphaFold DB: A0A0B7GM19

Similar proteins

Only experimentally validated proteins are listed.

Protein	Organism	Identities (%)	Coverage (%)	Ha-value
micA	Streptococcus pneumoniae Cp1015	82.833	100	0.828
vicR	Streptococcus mutans UA159	80.426	100	0.811
covR	Lactococcus lactis subsp. lactis strain DGCC12653	43.231	98.283	0.425
covR	Streptococcus salivarius strain HSISS4	42.174	98.712	0.416
scnR	Streptococcus mutans UA159	36.957	98.712	0.365