Detailed information    

insolico Bioinformatically predicted

Overview


Name   clpP   Type   Regulator
Locus tag   RRU92_RS09735 Genome accession   NZ_CP135436
Coordinates   2032187..2032777 (-) Length   196 a.a.
NCBI ID   WP_075232208.1    Uniprot ID   A0A1E8ZRR0
Organism   Streptococcus sp. DTU_2020_1001019_1_SI_AUS_MUR_006     
Function   degradation of ComX; degradation of ComW (predicted from homology)   
Competence regulation

Related MGE


Note: This gene co-localizes with putative mobile genetic elements (MGEs) in the genome predicted by VRprofile2, as detailed below.

Gene-MGE association summary

MGE type MGE coordinates Gene coordinates Relative position Distance (bp)
Prophage 2025687..2055948 2032187..2032777 within 0


Gene organization within MGE regions


Location: 2025687..2055948
Locus tag Gene name Coordinates (strand) Size (bp) Protein ID Product Description
  RRU92_RS09700 (RRU92_09700) - 2025687..2026943 (+) 1257 WP_315639098.1 ISL3 family transposase -
  RRU92_RS09705 (RRU92_09705) - 2027179..2027889 (-) 711 WP_075232203.1 ABC transporter ATP-binding protein -
  RRU92_RS09710 (RRU92_09710) - 2027889..2028653 (-) 765 WP_075232204.1 ABC transporter ATP-binding protein -
  RRU92_RS09715 (RRU92_09715) - 2028653..2029609 (-) 957 WP_075232205.1 branched-chain amino acid ABC transporter permease -
  RRU92_RS09720 (RRU92_09720) - 2029613..2030482 (-) 870 WP_075232206.1 branched-chain amino acid ABC transporter permease -
  RRU92_RS09725 (RRU92_09725) - 2030598..2031755 (-) 1158 WP_075232207.1 ABC transporter substrate-binding protein -
  RRU92_RS09730 (RRU92_09730) - 2031842..2032111 (-) 270 WP_049549362.1 YlbG family protein -
  RRU92_RS09735 (RRU92_09735) clpP 2032187..2032777 (-) 591 WP_075232208.1 ATP-dependent Clp protease proteolytic subunit ClpP Regulator
  RRU92_RS09740 (RRU92_09740) - 2032907..2033260 (-) 354 WP_075232209.1 DNA topoisomerase I -
  RRU92_RS09745 (RRU92_09745) upp 2033285..2033914 (-) 630 WP_315639667.1 uracil phosphoribosyltransferase -
  RRU92_RS09750 (RRU92_09750) - 2034002..2034469 (-) 468 WP_000136981.1 deoxycytidylate deaminase -
  RRU92_RS09755 (RRU92_09755) - 2034488..2035045 (-) 558 WP_315639670.1 TetR/AcrR family transcriptional regulator -
  RRU92_RS09760 (RRU92_09760) - 2035170..2036015 (+) 846 WP_153225536.1 DegV family protein -
  RRU92_RS09765 (RRU92_09765) - 2036073..2037239 (+) 1167 WP_153225291.1 NAD(P)/FAD-dependent oxidoreductase -
  RRU92_RS09770 (RRU92_09770) - 2037290..2037811 (+) 522 WP_061862833.1 DUF1697 domain-containing protein -
  RRU92_RS09775 (RRU92_09775) - 2037822..2038277 (+) 456 WP_315639671.1 8-oxo-dGTP diphosphatase -
  RRU92_RS09780 (RRU92_09780) - 2038385..2039125 (-) 741 WP_153225293.1 MerR family transcriptional regulator -
  RRU92_RS09785 (RRU92_09785) - 2039357..2040697 (+) 1341 WP_315639672.1 sodium-dependent transporter -
  RRU92_RS09790 (RRU92_09790) manA 2040743..2041687 (-) 945 WP_315639673.1 mannose-6-phosphate isomerase, class I -
  RRU92_RS09795 (RRU92_09795) - 2041809..2043248 (-) 1440 WP_315639675.1 6-phospho-beta-glucosidase -
  RRU92_RS09800 (RRU92_09800) - 2043414..2043992 (-) 579 WP_315639677.1 DUF3592 domain-containing protein -
  RRU92_RS09805 (RRU92_09805) - 2044136..2044483 (-) 348 WP_153225296.1 VOC family protein -
  RRU92_RS09810 (RRU92_09810) spxB 2044595..2046370 (-) 1776 WP_315639680.1 pyruvate oxidase -
  RRU92_RS09815 (RRU92_09815) - 2046694..2048916 (-) 2223 WP_315639681.1 heavy metal translocating P-type ATPase -
  RRU92_RS09820 (RRU92_09820) - 2048926..2049297 (-) 372 WP_315639682.1 cupredoxin domain-containing protein -
  RRU92_RS09825 (RRU92_09825) - 2049308..2049703 (-) 396 WP_315639683.1 CopY/TcrY family copper transport repressor -
  RRU92_RS09830 (RRU92_09830) - 2049907..2050587 (+) 681 WP_060956039.1 amino acid ABC transporter permease -
  RRU92_RS09835 (RRU92_09835) - 2050547..2051224 (+) 678 WP_315639685.1 amino acid ABC transporter permease -
  RRU92_RS09840 (RRU92_09840) - 2051225..2051983 (+) 759 WP_315639687.1 amino acid ABC transporter ATP-binding protein -
  RRU92_RS09845 (RRU92_09845) - 2052002..2052868 (+) 867 WP_315639688.1 cysteine ABC transporter substrate-binding protein -
  RRU92_RS09850 (RRU92_09850) pyrE 2053045..2053677 (-) 633 WP_315639690.1 orotate phosphoribosyltransferase -
  RRU92_RS09855 (RRU92_09855) pyrF 2053716..2054417 (-) 702 WP_315639691.1 orotidine-5'-phosphate decarboxylase -
  RRU92_RS09860 (RRU92_09860) - 2054674..2055948 (-) 1275 WP_315639692.1 cell division protein FtsQ/DivIB -

Sequence


Protein


Download         Length: 196 a.a.        Molecular weight: 21389.39 Da        Isoelectric Point: 4.4829

>NTDB_id=886565 RRU92_RS09735 WP_075232208.1 2032187..2032777(-) (clpP) [Streptococcus sp. DTU_2020_1001019_1_SI_AUS_MUR_006]
MIPVVIEQTSRGERSYDIYSRLLKDRIIMLTGPVEDNMANSVIAQLLFLDAQDSTKDIYLYVNTPGGSVSAGLAIVDTMN
FIKADVQTIVMGMAASMGTIIASSGAKGKRFMLPNAEYMIHQPMGGTGGGTQQTDMAIAAEHLLKTRKSLEQILADNSGK
SVEQIHADAERDYWMSAQETLEYGFIDEIMANNSLN

Nucleotide


Download         Length: 591 bp        

>NTDB_id=886565 RRU92_RS09735 WP_075232208.1 2032187..2032777(-) (clpP) [Streptococcus sp. DTU_2020_1001019_1_SI_AUS_MUR_006]
ATGATTCCTGTAGTAATTGAACAAACAAGTCGTGGGGAACGTTCCTACGATATCTACTCTCGTCTTTTGAAAGACCGCAT
CATCATGCTGACAGGTCCAGTTGAAGACAATATGGCAAACTCAGTTATTGCTCAGTTGCTCTTCTTGGATGCTCAAGACA
GCACTAAAGATATCTACCTCTATGTTAATACACCAGGTGGATCAGTTTCAGCTGGTTTGGCAATTGTAGATACTATGAAT
TTCATCAAAGCAGACGTACAAACGATTGTTATGGGTATGGCTGCCTCAATGGGAACTATTATCGCATCAAGTGGTGCTAA
GGGCAAACGCTTCATGCTTCCAAATGCAGAGTACATGATTCACCAACCGATGGGTGGTACTGGTGGTGGTACGCAACAGA
CAGATATGGCTATTGCGGCTGAGCACTTGCTTAAAACTCGTAAGTCTTTGGAGCAAATTCTTGCAGATAATTCTGGTAAA
TCAGTTGAGCAAATCCATGCAGATGCTGAACGTGATTACTGGATGAGCGCTCAAGAAACACTTGAATATGGTTTCATTGA
TGAAATCATGGCTAATAATTCTTTGAATTAA

Domains


Predicted by InterproScan.

(11-192)


Secondary structure


Protein secondary structures were predicted by S4PRED and visualized by seqviz.



3D structure


Source ID Structure
  AlphaFold DB A0A1E8ZRR0

Transmembrane helices


Transmembrane helices of protein were predicted by TMHMM 2.0 and visualized by seqviz and ECharts.



Visualization of predicted probability:


Similar proteins


Only experimentally validated proteins are listed.

Protein Organism Identities (%) Coverage (%) Ha-value
  clpP Streptococcus pneumoniae Rx1

94.898

100

0.949

  clpP Streptococcus pneumoniae D39

94.898

100

0.949

  clpP Streptococcus pneumoniae R6

94.898

100

0.949

  clpP Streptococcus pneumoniae TIGR4

94.898

100

0.949

  clpP Streptococcus thermophilus LMD-9

91.795

99.49

0.913

  clpP Streptococcus thermophilus LMG 18311

91.795

99.49

0.913

  clpP Streptococcus pyogenes JRS4

91.795

99.49

0.913

  clpP Streptococcus pyogenes MGAS315

91.795

99.49

0.913

  clpP Streptococcus mutans UA159

89.231

99.49

0.888

  clpP Lactococcus lactis subsp. lactis strain DGCC12653

88.205

99.49

0.878

  clpP Lactococcus lactis subsp. cremoris KW2

87.692

99.49

0.872

  clpP Campylobacter jejuni subsp. jejuni NCTC 11168 = ATCC 700819

58.031

98.469

0.571

  clpP Bacillus subtilis subsp. subtilis str. 168

57.292

97.959

0.561